Is CDHR4 p.Ala456Pro (c.1366G>C) pathogenic?

CDHR4 p.Ala456Pro (c.1366G>C) is classified Uncertain significance in CDHR4 (ClinVar, Single submitter, 1 submitter; last evaluated 2025-09-04). AlphaMissense: ambiguous (0.5019); Ultra-rare (popmax 0.0235%, amr).

How common is CDHR4 p.Ala456Pro (c.1366G>C) in the general population?

CDHR4 p.Ala456Pro (c.1366G>C) is ultra-rare (popmax 0.0235%, amr) (gnomAD).

What do computational predictors say about CDHR4 p.Ala456Pro (c.1366G>C)?

AlphaMissense predicts ambiguous (score 0.5019) — an in-silico prediction, not a clinical call.

CDHR4 p.Ala456Pro

c.1366G>C · rs1053583848 · VCV2213832

Uncertain significance Single submitter

Classification

Uncertain significance

ClinVar

Review

Single submitter ★☆☆☆

ClinVar · 1 submitter

AlphaMissense

ambiguous

0.5019 · ACMG-weighted

gnomAD v4.1

Rare

ultra-rare (popmax 0.0235%, amr)

Computational evidence

Protein change
AlphaMissense	0.5019	ambiguous
REVEL	0.346	indeterminate
SaProt	LLR -13.96	damaging
Splicing
SpliceAI	—	not assessed · no allele here is in the release
Constraint at this position
Conservation	phyloP 1.8	GERP 0.56, phastCons 0.93
Regional constraint	o/e 0.91	unconstrained · MANE · 8,977 bp · p 0.0033 · regional, not allelic
Overall
CADD	21.2	PHRED · no single calibrated threshold — expert panels disagree

AlphaMissense carries the ACMG weight for missense; REVEL and SaProt are independent agreement signals.

Population frequency

gnomAD v4.1 · exomes + genomes

Grpmax group 0.0235% Admixed American · 12/50,996 alleles

Filtering AF 0.0135% ClinGen BA1/BS1 input FAF95, joint · FAF99 0.0106%

Overall 0.000902% 14/1,551,676 alleles · ultra-rare

Ancestry group	Frequency	1 in
Admixed Americangrpmax	0.0235%	4,250
African / African-American	0.00274%	36,539

Rarity supports pathogenicity (ACMG PM2); frequency above a disease-specific BA1/BS1 threshold argues against it. A variant frequent in one ancestry group can be near-absent in others, so a single global figure can mislead.

Variant & gene context

Gene: CDHR4
Protein: p.Ala456Pro
Coding: c.1366G>C
MANE Select: NM_001007540
dbSNP: rs1053583848
Type: single nucleotide variant
Location: chr3:49793920 (GRCh38)
Gene constraint: LOEUF 1.174 · pLI <0.01 (gnomAD)
Structure: AlphaFold pLDDT 78.90
Residue 456: the cadherin 3 domain

Full CDHR4 gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Similar variants

CDHR4 p.Ala456Val Uncertain significance ★ ⚠ same residue
CDHR4 p.Ala12Val Uncertain significance ★ ⚠ same type
CDHR4 p.Ala149Val Uncertain significance ★ ⚠ same type
CDHR4 p.Ala302Val Uncertain significance ★ ⚠ same type
CDHR4 p.Ala310Pro Uncertain significance ★ ⚠ same type
CDHR4 p.Ala318Asp Uncertain significance ★ ⚠ same type
CDHR4 p.Ala341Pro Uncertain significance ★ ⚠ same type
CDHR4 p.Ala385Gly Uncertain significance ★ ⚠ same type

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/cdhr4-p-ala456pro (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown