CDHR4 — 133 ClinVar variants
All ClinVar germline CDHR4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 118 flagged for review →
18 Likely benign · 115 Uncertain significance
Full CDHR4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 118
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 53
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDHR4 p.Ala12Val Uncertain significance Single submitter
- CDHR4 p.Ala310Pro Uncertain significance Single submitter
- CDHR4 p.Ala318Asp Uncertain significance Single submitter
- CDHR4 p.Ala341Pro Uncertain significance Single submitter
- CDHR4 p.Ala385Gly Uncertain significance Single submitter
- CDHR4 p.Ala725Pro Uncertain significance Single submitter
- CDHR4 p.Ala727Val Uncertain significance Single submitter
- CDHR4 p.Arg120Gln Uncertain significance Single submitter
- CDHR4 p.Arg266His Uncertain significance Single submitter
- CDHR4 p.Arg597Gln Uncertain significance Single submitter
- CDHR4 p.Arg5Gly Uncertain significance Single submitter
- CDHR4 p.Arg652Gln Uncertain significance Single submitter
- CDHR4 p.Arg663Lys Uncertain significance Single submitter
- CDHR4 p.Asn323Ser Uncertain significance Single submitter
- CDHR4 p.Asp17Glu Uncertain significance Single submitter
- CDHR4 p.Asp264Asn Uncertain significance Single submitter
- CDHR4 p.Cys127Arg Uncertain significance Single submitter
- CDHR4 p.Gln100Leu Uncertain significance Single submitter
- CDHR4 p.Gln219Glu Uncertain significance Single submitter
- CDHR4 p.Gln233Leu Uncertain significance Single submitter
- CDHR4 p.Gln507Arg Uncertain significance Single submitter
- CDHR4 p.Gln522Arg Uncertain significance Single submitter
- CDHR4 p.Gln524His Uncertain significance Single submitter
- CDHR4 p.Gln601Glu Uncertain significance Single submitter
- CDHR4 p.Gln683Lys Uncertain significance Single submitter
- CDHR4 p.Gln716His Uncertain significance Single submitter
- CDHR4 p.Glu238Lys Uncertain significance Single submitter
- CDHR4 p.Glu254Gln Uncertain significance Single submitter
- CDHR4 p.Glu294Gln Uncertain significance Single submitter
- CDHR4 p.Glu312Lys Uncertain significance Single submitter
- CDHR4 p.Glu741Lys Uncertain significance Single submitter
- CDHR4 p.Gly285Asp Uncertain significance Single submitter
- CDHR4 p.His662Gln Uncertain significance Single submitter
- CDHR4 p.Ile243Val Uncertain significance Single submitter
- CDHR4 p.Leu333His Uncertain significance Single submitter
- CDHR4 p.Leu53Arg Uncertain significance Single submitter
- CDHR4 p.Leu718Pro Uncertain significance Single submitter
- CDHR4 p.Leu761Pro Uncertain significance Single submitter
- CDHR4 p.Met138Arg Uncertain significance Single submitter
- CDHR4 p.Met759Ile Uncertain significance Single submitter
- CDHR4 p.Phe11Ser Uncertain significance Single submitter
- CDHR4 p.Phe311Leu Uncertain significance Single submitter
- CDHR4 p.Pro485His Uncertain significance Single submitter
- CDHR4 p.Pro747Leu Uncertain significance Single submitter
- CDHR4 p.Pro747Ser Uncertain significance Single submitter
- CDHR4 p.Ser732Arg Uncertain significance Single submitter
- CDHR4 p.Trp317Arg Uncertain significance Single submitter
- CDHR4 p.Trp787Ser Uncertain significance Single submitter
- CDHR4 p.Val203Ile Uncertain significance Single submitter
- CDHR4 p.Val466Ala Uncertain significance Single submitter
- CDHR4 p.Val590Leu Uncertain significance Single submitter
- CDHR4 p.Val611Ala Uncertain significance Single submitter
- CDHR4 p.Val758Leu Uncertain significance Single submitter
Predictors split 65
The independent predictors disagree with each other — read with care.
- CDHR4 p.Ala149Val Uncertain significance Single submitter
- CDHR4 p.Ala302Val Uncertain significance Single submitter
- CDHR4 p.Ala456Pro Uncertain significance Single submitter
- CDHR4 p.Ala456Val Uncertain significance Single submitter
- CDHR4 p.Ala547Val Uncertain significance Single submitter
- CDHR4 p.Ala694Glu Uncertain significance Single submitter
- CDHR4 p.Arg120Trp Uncertain significance Single submitter
- CDHR4 p.Arg150Trp Uncertain significance Single submitter
- CDHR4 p.Arg266Cys Uncertain significance Single submitter
- CDHR4 p.Arg282Cys Uncertain significance Single submitter
- CDHR4 p.Arg288Gln Likely benign Single submitter
- CDHR4 p.Arg451Trp Uncertain significance Single submitter
- CDHR4 p.Arg492His Uncertain significance Single submitter
- CDHR4 p.Arg597Gly Uncertain significance Single submitter
- CDHR4 p.Asn525Lys Uncertain significance Single submitter
- CDHR4 p.Asp419Asn Uncertain significance Single submitter
- CDHR4 p.Asp475Glu Uncertain significance Single submitter
- CDHR4 p.Asp631Asn Uncertain significance Single submitter
- CDHR4 p.Asp769Asn Uncertain significance Single submitter
- CDHR4 p.Cys127Tyr Uncertain significance Single submitter
- CDHR4 p.Gln581Arg Uncertain significance Single submitter
- CDHR4 p.Glu478Lys Uncertain significance Single submitter
- CDHR4 p.Glu549Asp Uncertain significance Single submitter
- CDHR4 p.Gly187Ser Uncertain significance Single submitter
- CDHR4 p.Gly187Val Uncertain significance Single submitter
- CDHR4 p.Gly198Ser Uncertain significance Single submitter
- CDHR4 p.Gly252Ser Uncertain significance Single submitter
- CDHR4 p.Gly406Glu Uncertain significance Single submitter
- CDHR4 p.Gly463Asp Uncertain significance Single submitter
- CDHR4 p.Gly773Arg Uncertain significance Single submitter
- CDHR4 p.Gly79Ser Uncertain significance Single submitter
- CDHR4 p.Ile280Thr Uncertain significance Single submitter
- CDHR4 p.Leu10Phe Uncertain significance Single submitter
- CDHR4 p.Leu196Ile Uncertain significance Single submitter
- CDHR4 p.Leu270Pro Uncertain significance Single submitter
- CDHR4 p.Leu372Val Uncertain significance Single submitter
- CDHR4 p.Leu461Ile Uncertain significance Single submitter
- CDHR4 p.Leu499Phe Uncertain significance Single submitter
- CDHR4 p.Leu516Pro Uncertain significance Single submitter
- CDHR4 p.Leu703Ile Uncertain significance Single submitter
- CDHR4 p.Phe450Leu Uncertain significance Single submitter
- CDHR4 p.Pro157Leu Uncertain significance Single submitter
- CDHR4 p.Pro272Leu Uncertain significance Single submitter
- CDHR4 p.Pro336Leu Uncertain significance Single submitter
- CDHR4 p.Pro49Leu Uncertain significance Single submitter
- CDHR4 p.Pro68Ser Uncertain significance Single submitter
- CDHR4 p.Ser217Arg Uncertain significance Single submitter
- CDHR4 p.Ser279Cys Uncertain significance Single submitter
- CDHR4 p.Ser319Gly Uncertain significance Single submitter
- CDHR4 p.Ser494Arg Uncertain significance Single submitter
- CDHR4 p.Ser722Asn Uncertain significance Single submitter
- CDHR4 p.Thr35Ile Uncertain significance Single submitter
- CDHR4 p.Thr449Met Uncertain significance Single submitter
- CDHR4 p.Thr468Met Likely benign Single submitter
- CDHR4 p.Thr644Ala Uncertain significance Single submitter
- CDHR4 p.Thr669Met Likely benign Single submitter
- CDHR4 p.Val141Leu Uncertain significance Single submitter
- CDHR4 p.Val273Gly Uncertain significance Single submitter
- CDHR4 p.Val308Gly Uncertain significance Single submitter
- CDHR4 p.Val356Met Uncertain significance Single submitter
- CDHR4 p.Val465Met Uncertain significance Single submitter
- CDHR4 p.Val567Ala Uncertain significance Single submitter
- CDHR4 p.Val567Met Uncertain significance Single submitter
- CDHR4 p.Val8Met Uncertain significance Single submitter
- CDHR4 p.Val94Met Uncertain significance Single submitter
All CDHR4 variants
Likely benign 18
- p.Ala351Thr Single submitter
- p.Arg261Gln Single submitter
- p.Arg288Gln Single submitter ⚠
- p.Arg297His Single submitter
- p.Arg379His Single submitter
- p.Arg565His Single submitter
- p.Arg621His Single submitter
- p.Arg652Trp Single submitter
- p.Gly285Ser Single submitter
- p.Ile223Thr Single submitter
- p.Ile518Thr Single submitter
- p.Leu360Phe Single submitter
- p.Leu503= Single submitter
- p.Pro13Leu Single submitter
- p.Thr468Met Single submitter ⚠
- p.Thr636Ile Single submitter
- p.Thr669Met Single submitter ⚠
- p.Tyr560His Single submitter
Uncertain significance 115
- p.Ala12Val Single submitter ⚠
- p.Ala149Val Single submitter ⚠
- p.Ala302Val Single submitter ⚠
- p.Ala310Pro Single submitter ⚠
- p.Ala318Asp Single submitter ⚠
- p.Ala341Pro Single submitter ⚠
- p.Ala385Gly Single submitter ⚠
- p.Ala456Pro Single submitter ⚠
- p.Ala456Val Single submitter ⚠
- p.Ala547Val Single submitter ⚠
- p.Ala694Glu Single submitter ⚠
- p.Ala725Pro Single submitter ⚠
- p.Ala727Val Single submitter ⚠
- p.Arg120Gln Single submitter ⚠
- p.Arg120Trp Single submitter ⚠
- p.Arg150Trp Single submitter ⚠
- p.Arg266Cys Single submitter ⚠
- p.Arg266His Single submitter ⚠
- p.Arg282Cys Single submitter ⚠
- p.Arg451Trp Single submitter ⚠
- p.Arg492His Single submitter ⚠
- p.Arg597Gln Single submitter ⚠
- p.Arg597Gly Single submitter ⚠
- p.Arg5Gly Single submitter ⚠
- p.Arg652Gln Single submitter ⚠
- p.Arg663Lys Single submitter ⚠
- p.Asn323Ser Single submitter ⚠
- p.Asn525Lys Single submitter ⚠
- p.Asp17Glu Single submitter ⚠
- p.Asp264Asn Single submitter ⚠
- p.Asp419Asn Single submitter ⚠
- p.Asp475Glu Single submitter ⚠
- p.Asp631Asn Single submitter ⚠
- p.Asp769Asn Single submitter ⚠
- p.Cys127Arg Single submitter ⚠
- p.Cys127Tyr Single submitter ⚠
- p.Gln100Leu Single submitter ⚠
- p.Gln219Glu Single submitter ⚠
- p.Gln233Leu Single submitter ⚠
- p.Gln507Arg Single submitter ⚠
- p.Gln522Arg Single submitter ⚠
- p.Gln524His Single submitter ⚠
- p.Gln581Arg Single submitter ⚠
- p.Gln601Glu Single submitter ⚠
- p.Gln683Lys Single submitter ⚠
- p.Gln716His Single submitter ⚠
- p.Glu238Lys Single submitter ⚠
- p.Glu254Gln Single submitter ⚠
- p.Glu294Gln Single submitter ⚠
- p.Glu312Lys Single submitter ⚠
- p.Glu478Lys Single submitter ⚠
- p.Glu549Asp Single submitter ⚠
- p.Glu741Lys Single submitter ⚠
- p.Gly187Ser Single submitter ⚠
- p.Gly187Val Single submitter ⚠
- p.Gly198Ser Single submitter ⚠
- p.Gly252Ser Single submitter ⚠
- p.Gly285Asp Single submitter ⚠
- p.Gly406Glu Single submitter ⚠
- p.Gly463Asp Single submitter ⚠
- p.Gly773Arg Single submitter ⚠
- p.Gly79Ser Single submitter ⚠
- p.His662Gln Single submitter ⚠
- p.Ile243Val Single submitter ⚠
- p.Ile280Thr Single submitter ⚠
- p.Leu10Phe Single submitter ⚠
- p.Leu196Ile Single submitter ⚠
- p.Leu270Pro Single submitter ⚠
- p.Leu333His Single submitter ⚠
- p.Leu372Val Single submitter ⚠
- p.Leu461Ile Single submitter ⚠
- p.Leu499Phe Single submitter ⚠
- p.Leu516Pro Single submitter ⚠
- p.Leu53Arg Single submitter ⚠
- p.Leu703Ile Single submitter ⚠
- p.Leu718Pro Single submitter ⚠
- p.Leu761Pro Single submitter ⚠
- p.Met138Arg Single submitter ⚠
- p.Met759Ile Single submitter ⚠
- p.Phe11Ser Single submitter ⚠
- p.Phe311Leu Single submitter ⚠
- p.Phe450Leu Single submitter ⚠
- p.Pro157Leu Single submitter ⚠
- p.Pro272Leu Single submitter ⚠
- p.Pro336Leu Single submitter ⚠
- p.Pro485His Single submitter ⚠
- p.Pro49Leu Single submitter ⚠
- p.Pro68Ser Single submitter ⚠
- p.Pro747Leu Single submitter ⚠
- p.Pro747Ser Single submitter ⚠
- p.Ser217Arg Single submitter ⚠
- p.Ser279Cys Single submitter ⚠
- p.Ser319Gly Single submitter ⚠
- p.Ser494Arg Single submitter ⚠
- p.Ser722Asn Single submitter ⚠
- p.Ser732Arg Single submitter ⚠
- p.Thr35Ile Single submitter ⚠
- p.Thr449Met Single submitter ⚠
- p.Thr644Ala Single submitter ⚠
- p.Trp317Arg Single submitter ⚠
- p.Trp787Ser Single submitter ⚠
- p.Val141Leu Single submitter ⚠
- p.Val203Ile Single submitter ⚠
- p.Val273Gly Single submitter ⚠
- p.Val308Gly Single submitter ⚠
- p.Val356Met Single submitter ⚠
- p.Val465Met Single submitter ⚠
- p.Val466Ala Single submitter ⚠
- p.Val567Ala Single submitter ⚠
- p.Val567Met Single submitter ⚠
- p.Val590Leu Single submitter ⚠
- p.Val611Ala Single submitter ⚠
- p.Val758Leu Single submitter ⚠
- p.Val8Met Single submitter ⚠
- p.Val94Met Single submitter ⚠