Is CENPC p.Ser308Leu (c.923C>T) pathogenic?

CENPC p.Ser308Leu (c.923C>T) is classified Uncertain significance in CENPC (ClinVar, Single submitter, 1 submitter; last evaluated 2025-04-28). AlphaMissense: likely benign (0.154); Ultra-rare (popmax 0.0621%, sas).

How common is CENPC p.Ser308Leu (c.923C>T) in the general population?

CENPC p.Ser308Leu (c.923C>T) is ultra-rare (popmax 0.0621%, sas) (gnomAD).

What do computational predictors say about CENPC p.Ser308Leu (c.923C>T)?

AlphaMissense predicts likely benign (score 0.154) — an in-silico prediction, not a clinical call.

CENPC p.Ser308Leu

c.923C>T · VCV4000376

Uncertain significance Single submitter

Classification

Uncertain significance

ClinVar

Review

Single submitter ★☆☆☆

ClinVar · 1 submitter

AlphaMissense

likely benign

0.154 · ACMG-weighted

gnomAD v4.1

Rare

ultra-rare (popmax 0.0621%, sas)

Missense predictors

0/3 damaging

AlphaMissense, REVEL, SaProt

Computational evidence

Protein change
AlphaMissense	0.154	likely benign
REVEL	0.156	moderately benign-leaning
SaProt	LLR -6.54	tolerated
⇒ AlphaMissense, REVEL and SaProt all call this tolerated.
Splicing
SpliceAI	—	not assessed · no allele here is in the release
Constraint at this position
Conservation	phyloP 6.3	GERP 1.3, phastCons 1
Regional constraint	o/e 0.91	unconstrained · MANE · 73 kb · p 0.0018 · regional, not allelic
Overall
CADD	23.2	PHRED · no single calibrated threshold — expert panels disagree

ClinVar classifies this uncertain; the computational predictors unanimously lean tolerated — a triage signal, not a reclassification

AlphaMissense carries the ACMG weight for missense; REVEL and SaProt are independent agreement signals.

Population frequency

gnomAD v4.1 · exomes + genomes

Grpmax group 0.0621% South Asian · 56/90,116 alleles

Filtering AF 0.0491% ClinGen BA1/BS1 input FAF95, joint · FAF99 0.0444%

Overall 0.0051% 82/1,607,952 alleles · ultra-rare

Ancestry group	Frequency	1 in
South Asiangrpmax	0.0621%	1,609
Middle Eastern	0.0172%	5,802
Remaining individualsnot grpmax-eligible	0.0161%	6,226
East Asian	0.0112%	8,924
Admixed American	0.00338%	29,579
Finnishnot grpmax-eligible	0.00314%	31,820
European (non-Finnish)	0.00051%	196,208

Rarity supports pathogenicity (ACMG PM2); frequency above a disease-specific BA1/BS1 threshold argues against it. A variant frequent in one ancestry group can be near-absent in others, so a single global figure can mislead.

Variant & gene context

Gene: CENPC
Protein: p.Ser308Leu
Coding: c.923C>T
MANE Select: NM_001812
Type: single nucleotide variant
Location: chr4:67514595 (GRCh38)
Gene constraint: LOEUF 0.886 · pLI <0.01 (gnomAD)
Structure: AlphaFold pLDDT 48.33 · 17 PDB

Full CENPC gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Similar variants

CENPC p.Ala165Thr Uncertain significance ★ ⚠ same type
CENPC p.Ala23Val Uncertain significance ★ ⚠ same type
CENPC p.Ala313Val Uncertain significance ★ ⚠ same type
CENPC p.Ala324Thr Uncertain significance ★ ⚠ same type
CENPC p.Ala783Glu Uncertain significance ★ ⚠ same type
CENPC p.Ala783Thr Uncertain significance ★ ⚠ same type
CENPC p.Arg24His Uncertain significance ★ ⚠ same type
CENPC p.Arg272Gln Uncertain significance ★ ⚠ same type

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/cenpc-p-ser308leu (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown