CENPC — 130 ClinVar variants
All ClinVar germline CENPC variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 120 flagged for review →
11 Likely benign · 119 Uncertain significance
Full CENPC gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 120
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 96
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CENPC p.Ala165Thr Uncertain significance Single submitter
- CENPC p.Ala23Val Uncertain significance Single submitter
- CENPC p.Ala313Val Uncertain significance Single submitter
- CENPC p.Ala324Thr Uncertain significance Single submitter
- CENPC p.Ala783Glu Uncertain significance Single submitter
- CENPC p.Ala783Thr Uncertain significance Single submitter
- CENPC p.Arg272Gln Uncertain significance Single submitter
- CENPC p.Arg347Gly Uncertain significance Single submitter
- CENPC p.Arg521Gly Uncertain significance Single submitter
- CENPC p.Arg526Leu Uncertain significance Single submitter
- CENPC p.Arg64Ser Uncertain significance Single submitter
- CENPC p.Arg688Ser Uncertain significance Single submitter
- CENPC p.Arg738Leu Uncertain significance Single submitter
- CENPC p.Arg930Gln Uncertain significance Single submitter
- CENPC p.Asn188Lys Uncertain significance Single submitter
- CENPC p.Asn222Ser Uncertain significance Single submitter
- CENPC p.Asn352Asp Uncertain significance Single submitter
- CENPC p.Asn394Ile Uncertain significance Single submitter
- CENPC p.Asn49Ser Uncertain significance Single submitter
- CENPC p.Asn54Lys Uncertain significance Single submitter
- CENPC p.Asn555Ser Uncertain significance Single submitter
- CENPC p.Asn642Ser Uncertain significance Single submitter
- CENPC p.Asn722Lys Uncertain significance Single submitter
- CENPC p.Asn795Lys Uncertain significance Single submitter
- CENPC p.Asp226His Uncertain significance Single submitter
- CENPC p.Asp621Tyr Uncertain significance Single submitter
- CENPC p.Asp632Gly Uncertain significance Single submitter
- CENPC p.Asp672Asn Uncertain significance Single submitter
- CENPC p.Asp68Asn Uncertain significance Single submitter
- CENPC p.Asp802Gly Uncertain significance Single submitter
- CENPC p.Asp898Glu Uncertain significance Single submitter
- CENPC p.Cys633Tyr Uncertain significance Single submitter
- CENPC p.Cys70Phe Uncertain significance Single submitter
- CENPC p.Cys70Tyr Uncertain significance Single submitter
- CENPC p.Cys78Arg Uncertain significance Single submitter
- CENPC p.Gln374Arg Uncertain significance Single submitter
- CENPC p.Gln39His Uncertain significance Single submitter
- CENPC p.Gln650His Uncertain significance Single submitter
- CENPC p.Glu227Lys Uncertain significance Single submitter
- CENPC p.Glu228Gly Uncertain significance Single submitter
- CENPC p.Glu233Lys Uncertain significance Single submitter
- CENPC p.Glu467Gly Uncertain significance Single submitter
- CENPC p.Glu675Asp Uncertain significance Single submitter
- CENPC p.Gly5Ser Uncertain significance Single submitter
- CENPC p.Gly674Arg Uncertain significance Single submitter
- CENPC p.His114Arg Uncertain significance Single submitter
- CENPC p.His368Tyr Uncertain significance Single submitter
- CENPC p.His606Gln Uncertain significance Single submitter
- CENPC p.His8Arg Uncertain significance Single submitter
- CENPC p.His8Asp Uncertain significance Single submitter
- CENPC p.Ile218Thr Uncertain significance Single submitter
- CENPC p.Ile254Val Uncertain significance Single submitter
- CENPC p.Ile353Leu Uncertain significance Single submitter
- CENPC p.Ile417Val Uncertain significance Single submitter
- CENPC p.Ile646Phe Uncertain significance Single submitter
- CENPC p.Ile836Val Uncertain significance Single submitter
- CENPC p.Leu327Val Uncertain significance Single submitter
- CENPC p.Leu387Phe Uncertain significance Single submitter
- CENPC p.Leu47Val Uncertain significance Single submitter
- CENPC p.Leu837Phe Uncertain significance Single submitter
- CENPC p.Lys166Glu Uncertain significance Single submitter
- CENPC p.Lys345Gln Uncertain significance Single submitter
- CENPC p.Lys366Arg Uncertain significance Single submitter
- CENPC p.Lys378Glu Uncertain significance Single submitter
- CENPC p.Lys507Ile Uncertain significance Single submitter
- CENPC p.Lys573Arg Uncertain significance Single submitter
- CENPC p.Lys92Thr Uncertain significance Single submitter
- CENPC p.Pro103Arg Uncertain significance Single submitter
- CENPC p.Pro131Thr Uncertain significance Single submitter
- CENPC p.Pro159His Uncertain significance Single submitter
- CENPC p.Pro334Leu Uncertain significance Single submitter
- CENPC p.Pro375Leu Uncertain significance Single submitter
- CENPC p.Pro510Ser Uncertain significance Single submitter
- CENPC p.Pro539Ser Uncertain significance Single submitter
- CENPC p.Pro577Leu Uncertain significance Single submitter
- CENPC p.Pro876Thr Uncertain significance Single submitter
- CENPC p.Pro907Ser Uncertain significance Single submitter
- CENPC p.Ser274Arg Uncertain significance Single submitter
- CENPC p.Ser290Leu Uncertain significance Single submitter
- CENPC p.Ser308Leu Uncertain significance Single submitter
- CENPC p.Ser337Asn Uncertain significance Single submitter
- CENPC p.Ser447Leu Uncertain significance Single submitter
- CENPC p.Ser502Arg Uncertain significance Single submitter
- CENPC p.Ser620Arg Uncertain significance Single submitter
- CENPC p.Ser911Gly Uncertain significance Single submitter
- CENPC p.Thr130Ile Uncertain significance Single submitter
- CENPC p.Thr338Ile Uncertain significance Single submitter
- CENPC p.Thr561Ile Uncertain significance Single submitter
- CENPC p.Tyr541Cys Uncertain significance Single submitter
- CENPC p.Tyr917Cys Uncertain significance Single submitter
- CENPC p.Val156Ile Uncertain significance Single submitter
- CENPC p.Val169Ile Uncertain significance Single submitter
- CENPC p.Val190Ile Uncertain significance Single submitter
- CENPC p.Val436Leu Uncertain significance Single submitter
- CENPC p.Val790Ile Uncertain significance Single submitter
- CENPC p.Val88Phe Uncertain significance Single submitter
Predictors split 24
The independent predictors disagree with each other — read with care.
- CENPC p.Arg24His Uncertain significance Single submitter
- CENPC p.Arg499Cys Uncertain significance Single submitter
- CENPC p.Arg744Cys Uncertain significance Single submitter
- CENPC p.Arg752Gln Uncertain significance Single submitter
- CENPC p.Asn245Tyr Uncertain significance Single submitter
- CENPC p.Asn555Tyr Uncertain significance Single submitter
- CENPC p.Asn795Asp Uncertain significance Single submitter
- CENPC p.Asn925Ser Uncertain significance Single submitter
- CENPC p.Ile353Met Uncertain significance Single submitter
- CENPC p.Ile787Met Uncertain significance Single submitter
- CENPC p.Lys205Asn Uncertain significance Single submitter
- CENPC p.Lys797Arg Uncertain significance Single submitter
- CENPC p.Ser127Phe Uncertain significance Single submitter
- CENPC p.Ser200Leu Uncertain significance Single submitter
- CENPC p.Ser276Tyr Uncertain significance Single submitter
- CENPC p.Ser277Gly Uncertain significance Single submitter
- CENPC p.Ser333Phe Uncertain significance Single submitter
- CENPC p.Ser384Arg Uncertain significance Single submitter
- CENPC p.Ser474Tyr Uncertain significance Single submitter
- CENPC p.Ser502Gly Uncertain significance Single submitter
- CENPC p.Ser600Ala Uncertain significance Single submitter
- CENPC p.Ser90Leu Uncertain significance Single submitter
- CENPC p.Thr296Met Likely benign Single submitter
- CENPC p.Val767Met Uncertain significance Single submitter
All CENPC variants
Likely benign 11
- p.Arg248Gln Single submitter
- p.Asn664Lys Single submitter
- p.Asp435= Single submitter
- p.Glu598Lys Single submitter
- p.His445Arg Single submitter
- p.Ile787Thr Single submitter
- p.Met552Val Single submitter
- p.Pro479Leu Single submitter
- p.Ser613Leu Single submitter
- p.Thr296Met Single submitter ⚠
- p.Thr561Ala Single submitter
Uncertain significance 119
- p.Ala165Thr Single submitter ⚠
- p.Ala23Val Single submitter ⚠
- p.Ala313Val Single submitter ⚠
- p.Ala324Thr Single submitter ⚠
- p.Ala783Glu Single submitter ⚠
- p.Ala783Thr Single submitter ⚠
- p.Arg24His Single submitter ⚠
- p.Arg272Gln Single submitter ⚠
- p.Arg347Gly Single submitter ⚠
- p.Arg499Cys Single submitter ⚠
- p.Arg521Gly Single submitter ⚠
- p.Arg526Leu Single submitter ⚠
- p.Arg64Ser Single submitter ⚠
- p.Arg688Ser Single submitter ⚠
- p.Arg738Leu Single submitter ⚠
- p.Arg744Cys Single submitter ⚠
- p.Arg752Gln Single submitter ⚠
- p.Arg930Gln Single submitter ⚠
- p.Asn188Lys Single submitter ⚠
- p.Asn222Ser Single submitter ⚠
- p.Asn245Tyr Single submitter ⚠
- p.Asn352Asp Single submitter ⚠
- p.Asn394Ile Single submitter ⚠
- p.Asn49Ser Single submitter ⚠
- p.Asn54Lys Single submitter ⚠
- p.Asn555Ser Single submitter ⚠
- p.Asn555Tyr Single submitter ⚠
- p.Asn642Ser Single submitter ⚠
- p.Asn722Lys Single submitter ⚠
- p.Asn795Asp Single submitter ⚠
- p.Asn795Lys Single submitter ⚠
- p.Asn925Ser Single submitter ⚠
- p.Asp226His Single submitter ⚠
- p.Asp621Tyr Single submitter ⚠
- p.Asp632Gly Single submitter ⚠
- p.Asp672Asn Single submitter ⚠
- p.Asp68Asn Single submitter ⚠
- p.Asp802Gly Single submitter ⚠
- p.Asp898Glu Single submitter ⚠
- p.Cys633Tyr Single submitter ⚠
- p.Cys70Phe Single submitter ⚠
- p.Cys70Tyr Single submitter ⚠
- p.Cys78Arg Single submitter ⚠
- p.Gln374Arg Single submitter ⚠
- p.Gln39His Single submitter ⚠
- p.Gln650His Single submitter ⚠
- p.Glu227Lys Single submitter ⚠
- p.Glu228Gly Single submitter ⚠
- p.Glu233Lys Single submitter ⚠
- p.Glu467Gly Single submitter ⚠
- p.Glu675Asp Single submitter ⚠
- p.Gly5Ser Single submitter ⚠
- p.Gly674Arg Single submitter ⚠
- p.His114Arg Single submitter ⚠
- p.His368Tyr Single submitter ⚠
- p.His606Gln Single submitter ⚠
- p.His8Arg Single submitter ⚠
- p.His8Asp Single submitter ⚠
- p.Ile218Thr Single submitter ⚠
- p.Ile254Val Single submitter ⚠
- p.Ile353Leu Single submitter ⚠
- p.Ile353Met Single submitter ⚠
- p.Ile417Val Single submitter ⚠
- p.Ile646Phe Single submitter ⚠
- p.Ile787Met Single submitter ⚠
- p.Ile836Val Single submitter ⚠
- p.Leu327Val Single submitter ⚠
- p.Leu387Phe Single submitter ⚠
- p.Leu47Val Single submitter ⚠
- p.Leu837Phe Single submitter ⚠
- p.Lys166Glu Single submitter ⚠
- p.Lys205Asn Single submitter ⚠
- p.Lys345Gln Single submitter ⚠
- p.Lys366Arg Single submitter ⚠
- p.Lys378Glu Single submitter ⚠
- p.Lys507Ile Single submitter ⚠
- p.Lys573Arg Single submitter ⚠
- p.Lys797Arg Single submitter ⚠
- p.Lys92Thr Single submitter ⚠
- p.Pro103Arg Single submitter ⚠
- p.Pro131Thr Single submitter ⚠
- p.Pro159His Single submitter ⚠
- p.Pro334Leu Single submitter ⚠
- p.Pro375Leu Single submitter ⚠
- p.Pro510Ser Single submitter ⚠
- p.Pro539Ser Single submitter ⚠
- p.Pro577Leu Single submitter ⚠
- p.Pro876Thr Single submitter ⚠
- p.Pro907Ser Single submitter ⚠
- p.Ser127Phe Single submitter ⚠
- p.Ser200Leu Single submitter ⚠
- p.Ser274Arg Single submitter ⚠
- p.Ser276Tyr Single submitter ⚠
- p.Ser277Gly Single submitter ⚠
- p.Ser290Leu Single submitter ⚠
- p.Ser308Leu Single submitter ⚠
- p.Ser333Phe Single submitter ⚠
- p.Ser337Asn Single submitter ⚠
- p.Ser384Arg Single submitter ⚠
- p.Ser447Leu Single submitter ⚠
- p.Ser474Tyr Single submitter ⚠
- p.Ser502Arg Single submitter ⚠
- p.Ser502Gly Single submitter ⚠
- p.Ser600Ala Single submitter ⚠
- p.Ser620Arg Single submitter ⚠
- p.Ser90Leu Single submitter ⚠
- p.Ser911Gly Single submitter ⚠
- p.Thr130Ile Single submitter ⚠
- p.Thr338Ile Single submitter ⚠
- p.Thr561Ile Single submitter ⚠
- p.Tyr541Cys Single submitter ⚠
- p.Tyr917Cys Single submitter ⚠
- p.Val156Ile Single submitter ⚠
- p.Val169Ile Single submitter ⚠
- p.Val190Ile Single submitter ⚠
- p.Val436Leu Single submitter ⚠
- p.Val767Met Single submitter ⚠
- p.Val790Ile Single submitter ⚠
- p.Val88Phe Single submitter ⚠