Is CGAS p.Pro151Ala (c.451C>G) pathogenic?

CGAS p.Pro151Ala (c.451C>G) is classified Uncertain significance in CGAS (ClinVar, Single submitter, 1 submitter; last evaluated 2025-08-09). AlphaMissense: likely benign (0.0782); Very rare (popmax 0.00212%, nfe).

How common is CGAS p.Pro151Ala (c.451C>G) in the general population?

CGAS p.Pro151Ala (c.451C>G) is very rare (popmax 0.00212%, nfe) (gnomAD).

What do computational predictors say about CGAS p.Pro151Ala (c.451C>G)?

AlphaMissense predicts likely benign (score 0.0782) — an in-silico prediction, not a clinical call.

CGAS p.Pro151Ala

c.451C>G · VCV4227459

Uncertain significance Single submitter

Classification

Uncertain significance

ClinVar

Review

Single submitter ★☆☆☆

ClinVar · 1 submitter

AlphaMissense

likely benign

0.0782 · ACMG-weighted

gnomAD v4.1

Rare

very rare (popmax 0.00212%, nfe)

Missense predictors

0/3 damaging

AlphaMissense, REVEL, SaProt

Computational evidence

Protein change
AlphaMissense	0.0782	likely benign
REVEL	0.017	moderately benign-leaning
SaProt	LLR -6.93	tolerated
⇒ AlphaMissense, REVEL and SaProt all call this tolerated.
Splicing
SpliceAI	—	not assessed · no allele here is in the release
Constraint at this position
Conservation	phyloP -0.06	GERP -2
Regional constraint	o/e 1.02	unconstrained · MANE · 6,445 bp · p 0.71 · regional, not allelic
Overall
CADD	1.201	PHRED · no single calibrated threshold — expert panels disagree

ClinVar classifies this uncertain; the computational predictors unanimously lean tolerated — a triage signal, not a reclassification

AlphaMissense carries the ACMG weight for missense; REVEL and SaProt are independent agreement signals.

Population frequency

gnomAD v4.1 · exomes + genomes

Grpmax group 0.00212% European (non-Finnish) · 25/1,179,762 alleles

Filtering AF 0.00145% ClinGen BA1/BS1 input FAF95, joint · FAF99 0.00123%

Overall 0.00161% 26/1,612,890 alleles · very rare

Ancestry group	Frequency	1 in
European (non-Finnish)grpmax	0.00212%	47,191
Admixed American	0.00167%	59,952

Rarity supports pathogenicity (ACMG PM2); frequency above a disease-specific BA1/BS1 threshold argues against it. A variant frequent in one ancestry group can be near-absent in others, so a single global figure can mislead.

Variant & gene context

Gene: CGAS
Protein: p.Pro151Ala
Coding: c.451C>G
MANE Select: NM_138441
Type: single nucleotide variant
Location: chr6:73451731 (GRCh38)
Gene constraint: LOEUF 1.529 · pLI <0.01 (gnomAD)
Structure: AlphaFold pLDDT 78.38 · 107 PDB
Residue 151: the 'dna-binding' region; the 'required for activation upon dna viral infection' region

Full CGAS gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Similar variants

CGAS p.Ala109Glu Uncertain significance ★ ⚠ same type
CGAS p.Ala118Asp Uncertain significance ★ ⚠ same type
CGAS p.Ala158Val Uncertain significance ★ ⚠ same type
CGAS p.Ala167Pro Uncertain significance ★ ⚠ same type
CGAS p.Ala167Val Uncertain significance ★ ⚠ same type
CGAS p.Ala17Gly Conflicting classifications of pathogenicity ★ ⚠ same type
CGAS p.Ala247Glu Uncertain significance ★ ⚠ same type
CGAS p.Ala24Ser Uncertain significance ★ ⚠ same type

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/cgas-p-pro151ala (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown