CGAS — 87 ClinVar variants
All ClinVar germline CGAS variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 84 flagged for review →
1 Conflicting · 3 Likely benign · 83 Uncertain significance
Full CGAS gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 84
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
Predictors lean, ClinVar uncertain 50
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CGAS p.Ala158Val Uncertain significance Single submitter
- CGAS p.Ala24Ser Uncertain significance Single submitter
- CGAS p.Ala30Ser Uncertain significance Single submitter
- CGAS p.Ala364Thr Uncertain significance Single submitter
- CGAS p.Ala43Thr Uncertain significance Single submitter
- CGAS p.Ala54Ser Uncertain significance Single submitter
- CGAS p.Ala65Val Uncertain significance Single submitter
- CGAS p.Ala79Ser Uncertain significance Single submitter
- CGAS p.Ala81Thr Uncertain significance Single submitter
- CGAS p.Arg117Ser Uncertain significance Single submitter
- CGAS p.Arg133Thr Uncertain significance Single submitter
- CGAS p.Arg155Pro Uncertain significance Single submitter
- CGAS p.Arg166Gln Uncertain significance Single submitter
- CGAS p.Arg246His Uncertain significance Single submitter
- CGAS p.Arg255Gly Uncertain significance Single submitter
- CGAS p.Arg25Leu Uncertain significance Single submitter
- CGAS p.Arg339Cys Uncertain significance Single submitter
- CGAS p.Arg339His Uncertain significance Single submitter
- CGAS p.Arg457His Uncertain significance Single submitter
- CGAS p.Arg512Lys Uncertain significance Single submitter
- CGAS p.Asn399Lys Uncertain significance Single submitter
- CGAS p.Asn489Tyr Uncertain significance Single submitter
- CGAS p.Asp90Val Uncertain significance Single submitter
- CGAS p.Gln123Lys Uncertain significance Single submitter
- CGAS p.Glu383Lys Uncertain significance Single submitter
- CGAS p.Gly137Glu Uncertain significance Single submitter
- CGAS p.Gly188Val Uncertain significance Single submitter
- CGAS p.Gly205Ser Uncertain significance Single submitter
- CGAS p.Gly367Glu Uncertain significance Single submitter
- CGAS p.Gly391Glu Uncertain significance Single submitter
- CGAS p.His437Arg Uncertain significance Single submitter
- CGAS p.Ile152Thr Uncertain significance Single submitter
- CGAS p.Ile316Thr Uncertain significance Single submitter
- CGAS p.Leu146Arg Uncertain significance Single submitter
- CGAS p.Lys327Thr Uncertain significance Single submitter
- CGAS p.Lys347Glu Uncertain significance Single submitter
- CGAS p.Lys63Gln Uncertain significance Single submitter
- CGAS p.Lys82Thr Uncertain significance Single submitter
- CGAS p.Met9Val Uncertain significance Single submitter
- CGAS p.Phe442Cys Uncertain significance Single submitter
- CGAS p.Pro132Ala Uncertain significance Single submitter
- CGAS p.Pro144Leu Uncertain significance Single submitter
- CGAS p.Pro147Arg Uncertain significance Single submitter
- CGAS p.Pro151Ala Uncertain significance Single submitter
- CGAS p.Pro3Arg Uncertain significance Single submitter
- CGAS p.Ser201Cys Uncertain significance Single submitter
- CGAS p.Thr35Pro Uncertain significance Single submitter
- CGAS p.Trp139Gly Uncertain significance Single submitter
- CGAS p.Tyr436His Uncertain significance Single submitter
- CGAS p.Val445Ile Uncertain significance Single submitter
Predictors split 33
The independent predictors disagree with each other — read with care.
- CGAS p.Ala109Glu Uncertain significance Single submitter
- CGAS p.Ala118Asp Uncertain significance Single submitter
- CGAS p.Ala167Pro Uncertain significance Single submitter
- CGAS p.Ala167Val Uncertain significance Single submitter
- CGAS p.Ala247Glu Uncertain significance Single submitter
- CGAS p.Ala43Asp Uncertain significance Single submitter
- CGAS p.Ala48Ser Uncertain significance Single submitter
- CGAS p.Arg155Trp Uncertain significance Single submitter
- CGAS p.Arg28Trp Uncertain significance Single submitter
- CGAS p.Arg376Gln Uncertain significance Single submitter
- CGAS p.Arg457Cys Uncertain significance Single submitter
- CGAS p.Arg476Gly Uncertain significance Single submitter
- CGAS p.Arg60Trp Uncertain significance Single submitter
- CGAS p.Arg80Leu Uncertain significance Single submitter
- CGAS p.Asp452Val Uncertain significance Single submitter
- CGAS p.Cys199Trp Uncertain significance Single submitter
- CGAS p.Glu106Lys Uncertain significance Single submitter
- CGAS p.Glu42Lys Uncertain significance Single submitter
- CGAS p.His390Arg Uncertain significance Single submitter
- CGAS p.Ile284Leu Uncertain significance Single submitter
- CGAS p.Leu239Pro Uncertain significance Single submitter
- CGAS p.Leu311Ile Uncertain significance Single submitter
- CGAS p.Leu311Pro Uncertain significance Single submitter
- CGAS p.Lys425Asn Uncertain significance Single submitter
- CGAS p.Phe433Leu Uncertain significance Single submitter
- CGAS p.Phe503Ile Uncertain significance Single submitter
- CGAS p.Pro486Ala Uncertain significance Single submitter
- CGAS p.Ser180Phe Uncertain significance Single submitter
- CGAS p.Ser272Leu Uncertain significance Single submitter
- CGAS p.Ser393Cys Uncertain significance Single submitter
- CGAS p.Ser393Tyr Uncertain significance Single submitter
- CGAS p.Val218Leu Uncertain significance Single submitter
- CGAS p.Val74Ile Uncertain significance Single submitter
All CGAS variants
Conflicting classifications of pathogenicity 1
- p.Ala17Gly Single submitter ⚠
Likely benign 3
- p.Ala96Ser Single submitter
- p.Asp140Glu Single submitter
- p.Trp139Arg Single submitter
Uncertain significance 83
- p.Ala109Glu Single submitter ⚠
- p.Ala118Asp Single submitter ⚠
- p.Ala158Val Single submitter ⚠
- p.Ala167Pro Single submitter ⚠
- p.Ala167Val Single submitter ⚠
- p.Ala247Glu Single submitter ⚠
- p.Ala24Ser Single submitter ⚠
- p.Ala30Ser Single submitter ⚠
- p.Ala364Thr Single submitter ⚠
- p.Ala43Asp Single submitter ⚠
- p.Ala43Thr Single submitter ⚠
- p.Ala48Ser Single submitter ⚠
- p.Ala54Ser Single submitter ⚠
- p.Ala65Val Single submitter ⚠
- p.Ala79Ser Single submitter ⚠
- p.Ala81Thr Single submitter ⚠
- p.Arg117Ser Single submitter ⚠
- p.Arg133Thr Single submitter ⚠
- p.Arg155Pro Single submitter ⚠
- p.Arg155Trp Single submitter ⚠
- p.Arg166Gln Single submitter ⚠
- p.Arg246His Single submitter ⚠
- p.Arg255Gly Single submitter ⚠
- p.Arg25Leu Single submitter ⚠
- p.Arg28Trp Single submitter ⚠
- p.Arg339Cys Single submitter ⚠
- p.Arg339His Single submitter ⚠
- p.Arg376Gln Single submitter ⚠
- p.Arg457Cys Single submitter ⚠
- p.Arg457His Single submitter ⚠
- p.Arg476Gly Single submitter ⚠
- p.Arg512Lys Single submitter ⚠
- p.Arg60Trp Single submitter ⚠
- p.Arg80Leu Single submitter ⚠
- p.Asn399Lys Single submitter ⚠
- p.Asn489Tyr Single submitter ⚠
- p.Asp452Val Single submitter ⚠
- p.Asp90Val Single submitter ⚠
- p.Cys199Trp Single submitter ⚠
- p.Gln123Lys Single submitter ⚠
- p.Glu106Lys Single submitter ⚠
- p.Glu383Lys Single submitter ⚠
- p.Glu42Lys Single submitter ⚠
- p.Gly137Glu Single submitter ⚠
- p.Gly188Val Single submitter ⚠
- p.Gly205Ser Single submitter ⚠
- p.Gly367Glu Single submitter ⚠
- p.Gly391Glu Single submitter ⚠
- p.His390Arg Single submitter ⚠
- p.His437Arg Single submitter ⚠
- p.Ile152Thr Single submitter ⚠
- p.Ile284Leu Single submitter ⚠
- p.Ile316Thr Single submitter ⚠
- p.Leu146Arg Single submitter ⚠
- p.Leu239Pro Single submitter ⚠
- p.Leu311Ile Single submitter ⚠
- p.Leu311Pro Single submitter ⚠
- p.Lys327Thr Single submitter ⚠
- p.Lys347Glu Single submitter ⚠
- p.Lys425Asn Single submitter ⚠
- p.Lys63Gln Single submitter ⚠
- p.Lys82Thr Single submitter ⚠
- p.Met9Val Single submitter ⚠
- p.Phe433Leu Single submitter ⚠
- p.Phe442Cys Single submitter ⚠
- p.Phe503Ile Single submitter ⚠
- p.Pro132Ala Single submitter ⚠
- p.Pro144Leu Single submitter ⚠
- p.Pro147Arg Single submitter ⚠
- p.Pro151Ala Single submitter ⚠
- p.Pro3Arg Single submitter ⚠
- p.Pro486Ala Single submitter ⚠
- p.Ser180Phe Single submitter ⚠
- p.Ser201Cys Single submitter ⚠
- p.Ser272Leu Single submitter ⚠
- p.Ser393Cys Single submitter ⚠
- p.Ser393Tyr Single submitter ⚠
- p.Thr35Pro Single submitter ⚠
- p.Trp139Gly Single submitter ⚠
- p.Tyr436His Single submitter ⚠
- p.Val218Leu Single submitter ⚠
- p.Val445Ile Single submitter ⚠
- p.Val74Ile Single submitter ⚠