CLK3 c.19C>T
Uncertain significance
Single submitter
Classification
Uncertain significance
ClinVar
Review
Single submitter ★☆☆☆
ClinVar · 1 submitter
gnomAD v4.1
Rare
Computational evidence
| Protein change | ||
| Missense predictors do not apply to this variant type. |
Variant & gene context
- Gene
- CLK3
- Coding
- c.19C>T
- MANE Select
- NM_001130028
- Type
- single nucleotide variant
- Gene constraint
- LOEUF 0.505 · pLI 0.97 (gnomAD)
- Structure
- AlphaFold pLDDT 78.27 · 22 PDB
Similar variants
- CLK3 p.Pro89Arg Uncertain significance ★★ ⚠ same type
- CLK3 c.125G>A Uncertain significance ★ same type
- CLK3 c.310C>T Uncertain significance ★ same type
- CLK3 c.374T>G Uncertain significance ★ same type
- CLK3 c.-1+1G>C Uncertain significance ★ same type
- CLK3 c.-12G>C Uncertain significance ★ ⚠ same type
- CLK3 c.-12G>T Uncertain significance ★ ⚠ same type
- CLK3 c.-24G>C Uncertain significance ★ ⚠ same type
Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →
Cite Sugi Variant
Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/clk3-c-19c-t (accessed [today's date]).
Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown