CLK3 — 103 ClinVar variants
All ClinVar germline CLK3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 85 flagged for review →
1 Likely benign · 102 Uncertain significance
Full CLK3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 85
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 72
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CLK3 p.Pro89Arg Uncertain significance Multiple submitters
- CLK3 c.-12G>C Uncertain significance Single submitter
- CLK3 c.-12G>T Uncertain significance Single submitter
- CLK3 c.-24G>C Uncertain significance Single submitter
- CLK3 c.-47C>G Uncertain significance Single submitter
- CLK3 c.-48G>A Uncertain significance Single submitter
- CLK3 c.-57G>A Uncertain significance Single submitter
- CLK3 p.Ala58Thr Uncertain significance Single submitter
- CLK3 p.Ala98Val Uncertain significance Single submitter
- CLK3 p.Arg104His Uncertain significance Single submitter
- CLK3 p.Arg199Gln Uncertain significance Single submitter
- CLK3 p.Arg19Gln Uncertain significance Single submitter
- CLK3 p.Arg20Gln Uncertain significance Single submitter
- CLK3 p.Arg20Pro Uncertain significance Single submitter
- CLK3 p.Arg272Lys Uncertain significance Single submitter
- CLK3 p.Arg28Gln Uncertain significance Single submitter
- CLK3 p.Arg28Trp Uncertain significance Single submitter
- CLK3 p.Arg39Gln Uncertain significance Single submitter
- CLK3 p.Arg400Cys Uncertain significance Single submitter
- CLK3 p.Arg451Lys Uncertain significance Single submitter
- CLK3 p.Arg45Gln Uncertain significance Single submitter
- CLK3 p.Arg45Gly Uncertain significance Single submitter
- CLK3 p.Arg49Pro Uncertain significance Single submitter
- CLK3 p.Arg50Lys Uncertain significance Single submitter
- CLK3 p.Arg54Cys Uncertain significance Single submitter
- CLK3 p.Arg54Gly Uncertain significance Single submitter
- CLK3 p.Arg62Gln Uncertain significance Single submitter
- CLK3 p.Arg62Trp Uncertain significance Single submitter
- CLK3 p.Arg65His Uncertain significance Single submitter
- CLK3 p.Arg66Cys Uncertain significance Single submitter
- CLK3 p.Arg71Trp Uncertain significance Single submitter
- CLK3 p.Arg75Gln Uncertain significance Single submitter
- CLK3 p.Arg78Leu Uncertain significance Single submitter
- CLK3 p.Arg78Ser Uncertain significance Single submitter
- CLK3 p.Arg82Gln Uncertain significance Single submitter
- CLK3 p.Arg88Cys Uncertain significance Single submitter
- CLK3 p.Arg92Cys Uncertain significance Single submitter
- CLK3 p.Arg93Trp Uncertain significance Single submitter
- CLK3 p.Arg96Leu Uncertain significance Single submitter
- CLK3 p.Cys118Tyr Uncertain significance Single submitter
- CLK3 p.Cys88Gly Uncertain significance Single submitter
- CLK3 p.Glu41Gly Uncertain significance Single submitter
- CLK3 p.Glu81Gln Uncertain significance Single submitter
- CLK3 p.Gly30Glu Uncertain significance Single submitter
- CLK3 p.Gly61Trp Uncertain significance Single submitter
- CLK3 p.Gly63Val Uncertain significance Single submitter
- CLK3 p.Gly69Arg Uncertain significance Single submitter
- CLK3 p.Gly69Ser Uncertain significance Single submitter
- CLK3 p.Gly84Val Uncertain significance Single submitter
- CLK3 p.His2Arg Uncertain significance Single submitter
- CLK3 p.His30Arg Uncertain significance Single submitter
- CLK3 p.Leu120Gln Uncertain significance Single submitter
- CLK3 p.Leu221Phe Uncertain significance Single submitter
- CLK3 p.Leu390Pro Uncertain significance Single submitter
- CLK3 p.Leu75Phe Uncertain significance Single submitter
- CLK3 p.Lys105Asn Uncertain significance Single submitter
- CLK3 p.Met449Lys Uncertain significance Single submitter
- CLK3 p.Pro10Ser Uncertain significance Single submitter
- CLK3 p.Pro44Arg Uncertain significance Single submitter
- CLK3 p.Pro488Ser Uncertain significance Single submitter
- CLK3 p.Pro77Ala Uncertain significance Single submitter
- CLK3 p.Ser133Thr Uncertain significance Single submitter
- CLK3 p.Ser34Leu Uncertain significance Single submitter
- CLK3 p.Ser419Cys Uncertain significance Single submitter
- CLK3 p.Ser67Gly Uncertain significance Single submitter
- CLK3 p.Thr69Ile Uncertain significance Single submitter
- CLK3 p.Tyr57Cys Uncertain significance Single submitter
- CLK3 p.Tyr57Ser Uncertain significance Single submitter
- CLK3 p.Tyr84Cys Uncertain significance Single submitter
- CLK3 p.Val159Leu Uncertain significance Single submitter
- CLK3 p.Val357Ile Uncertain significance Single submitter
- CLK3 p.Val443Met Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- CLK3 c.-35A>C Uncertain significance Single submitter
- CLK3 p.Arg113His Uncertain significance Single submitter
- CLK3 p.Arg480Trp Uncertain significance Single submitter
- CLK3 p.Arg48Gln Uncertain significance Single submitter
- CLK3 p.Arg48Trp Uncertain significance Single submitter
- CLK3 p.Arg54His Uncertain significance Single submitter
- CLK3 p.Arg6Gln Uncertain significance Single submitter
- CLK3 p.Asp438His Uncertain significance Single submitter
- CLK3 p.Glu295Lys Uncertain significance Single submitter
- CLK3 p.Lys211Glu Uncertain significance Single submitter
- CLK3 p.Ser181Pro Uncertain significance Single submitter
- CLK3 p.Ser49Pro Uncertain significance Single submitter
- CLK3 p.Thr476Ile Uncertain significance Single submitter
All CLK3 variants
Likely benign 1
- c.-51G>A Single submitter
Uncertain significance 102
- p.Pro89Arg Multiple submitters ⚠
- c.125G>A Single submitter
- c.19C>T Single submitter
- c.310C>T Single submitter
- c.374T>G Single submitter
- c.-12G>C Single submitter ⚠
- c.-12G>T Single submitter ⚠
- c.-24G>C Single submitter ⚠
- c.-35A>C Single submitter ⚠
- c.-47C>G Single submitter ⚠
- c.-48G>A Single submitter ⚠
- c.-57G>A Single submitter ⚠
- p.Ala270Thr Single submitter
- p.Ala58Thr Single submitter ⚠
- p.Ala98Val Single submitter ⚠
- p.Arg104His Single submitter ⚠
- p.Arg113His Single submitter ⚠
- p.Arg195Trp Single submitter
- p.Arg199Gln Single submitter ⚠
- p.Arg19Gln Single submitter ⚠
- p.Arg20Gln Single submitter ⚠
- p.Arg20Pro Single submitter ⚠
- p.Arg272Lys Single submitter ⚠
- p.Arg28Gln Single submitter ⚠
- p.Arg28Trp Single submitter ⚠
- p.Arg39Gln Single submitter ⚠
- p.Arg400Cys Single submitter ⚠
- p.Arg451Lys Single submitter ⚠
- p.Arg45Gln Single submitter ⚠
- p.Arg45Gly Single submitter ⚠
- p.Arg480Trp Single submitter ⚠
- p.Arg48Gln Single submitter ⚠
- p.Arg48Trp Single submitter ⚠
- p.Arg49Pro Single submitter ⚠
- p.Arg50Lys Single submitter ⚠
- p.Arg54Cys Single submitter ⚠
- p.Arg54Gly Single submitter ⚠
- p.Arg54His Single submitter ⚠
- p.Arg62Gln Single submitter ⚠
- p.Arg62Trp Single submitter ⚠
- p.Arg65His Single submitter ⚠
- p.Arg66Cys Single submitter ⚠
- p.Arg6Gln Single submitter ⚠
- p.Arg71Pro Single submitter
- p.Arg71Trp Single submitter ⚠
- p.Arg75Gln Single submitter ⚠
- p.Arg78Leu Single submitter ⚠
- p.Arg78Ser Single submitter ⚠
- p.Arg82Gln Single submitter ⚠
- p.Arg88Cys Single submitter ⚠
- p.Arg92Cys Single submitter ⚠
- p.Arg93Trp Single submitter ⚠
- p.Arg96Leu Single submitter ⚠
- p.Asp438His Single submitter ⚠
- p.Cys118Tyr Single submitter ⚠
- p.Cys88Gly Single submitter ⚠
- p.Glu249Ala Single submitter
- p.Glu295Lys Single submitter ⚠
- p.Glu307Val Single submitter
- p.Glu41Gly Single submitter ⚠
- p.Glu81Gln Single submitter ⚠
- p.Gly30Glu Single submitter ⚠
- p.Gly421Asp Single submitter
- p.Gly421Ser Single submitter
- p.Gly61Trp Single submitter ⚠
- p.Gly63Val Single submitter ⚠
- p.Gly69Arg Single submitter ⚠
- p.Gly69Ser Single submitter ⚠
- p.Gly84Val Single submitter ⚠
- p.His2Arg Single submitter ⚠
- p.His30Arg Single submitter ⚠
- p.Ile334Thr Single submitter
- p.Leu120Gln Single submitter ⚠
- p.Leu221Phe Single submitter ⚠
- p.Leu390Pro Single submitter ⚠
- p.Leu75Phe Single submitter ⚠
- p.Lys105Asn Single submitter ⚠
- p.Lys211Glu Single submitter ⚠
- p.Met222Ile Single submitter
- p.Met449Lys Single submitter ⚠
- p.Phe455Leu Single submitter
- p.Pro10Ser Single submitter ⚠
- p.Pro342Leu Single submitter
- p.Pro44Arg Single submitter ⚠
- p.Pro488Ser Single submitter ⚠
- p.Pro77Ala Single submitter ⚠
- p.Ser133Thr Single submitter ⚠
- p.Ser181Pro Single submitter ⚠
- p.Ser34Leu Single submitter ⚠
- p.Ser419Cys Single submitter ⚠
- p.Ser49Pro Single submitter ⚠
- p.Ser67Gly Single submitter ⚠
- p.Thr476Ile Single submitter ⚠
- p.Thr69Ile Single submitter ⚠
- p.Tyr57Cys Single submitter ⚠
- p.Tyr57Ser Single submitter ⚠
- p.Tyr84Cys Single submitter ⚠
- p.Val159Leu Single submitter ⚠
- p.Val191Met Single submitter
- p.Val357Ala Single submitter
- p.Val357Ile Single submitter ⚠
- p.Val443Met Single submitter ⚠