Is CORO1B p.Pro301Ala (c.901C>G) pathogenic?

CORO1B p.Pro301Ala (c.901C>G) is classified Uncertain significance in CORO1B (ClinVar, Single submitter, 1 submitter; last evaluated 2025-11-20). AlphaMissense: likely benign (0.0528); Absent from gnomAD v4.1.

How common is CORO1B p.Pro301Ala (c.901C>G) in the general population?

CORO1B p.Pro301Ala (c.901C>G) is absent from gnomAD v4.1 (gnomAD).

What do computational predictors say about CORO1B p.Pro301Ala (c.901C>G)?

AlphaMissense predicts likely benign (score 0.0528) — an in-silico prediction, not a clinical call.

CORO1B p.Pro301Ala

c.901C>G · VCV4655915

Uncertain significance Single submitter

Classification

Uncertain significance

ClinVar

Review

Single submitter ★☆☆☆

ClinVar · 1 submitter

AlphaMissense

likely benign

0.0528 · ACMG-weighted

gnomAD v4.1

Absent

absent from gnomAD v4.1

Missense predictors

0/3 damaging

AlphaMissense, REVEL, SaProt

Computational evidence

Protein change
AlphaMissense	0.0528	likely benign
REVEL	0.045	moderately benign-leaning
SaProt	LLR -5.06	tolerated
⇒ AlphaMissense, REVEL and SaProt all call this tolerated.
Splicing
SpliceAI	—	not assessed · no allele here is in the release
Constraint at this position
Conservation	phyloP -0.16	GERP -5, phastCons 0.068
Regional constraint	o/e 0.93	unconstrained · MANE · 4,249 bp · p 0.048 · regional, not allelic
Overall
CADD	5.313	PHRED · no single calibrated threshold — expert panels disagree

ClinVar classifies this uncertain; the computational predictors unanimously lean tolerated — a triage signal, not a reclassification

AlphaMissense carries the ACMG weight for missense; REVEL and SaProt are independent agreement signals.

Population frequency

gnomAD v4.1 · exomes + genomes

Absent from gnomAD v4.1. Not observed in any sequenced alleles — a rarity signal (ACMG PM2-supporting), not evidence of pathogenicity on its own.

Variant & gene context

Gene: CORO1B
Protein: p.Pro301Ala
Coding: c.901C>G
MANE Select: NM_020441
Type: single nucleotide variant
Location: chr11:67440224 (GRCh38)
Gene constraint: LOEUF 0.793 · pLI <0.01 (gnomAD)
Structure: AlphaFold pLDDT 90.18 · 6 PDB

Full CORO1B gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Similar variants

CORO1B p.Ala139Ser Uncertain significance ★ ⚠ same type
CORO1B p.Ala248Val Uncertain significance ★ ⚠ same type
CORO1B p.Ala385Gly Uncertain significance ★ ⚠ same type
CORO1B p.Ala450Ser Uncertain significance ★ ⚠ same type
CORO1B p.Ala462Val Uncertain significance ★ ⚠ same type
CORO1B p.Arg134Gln Uncertain significance ★ ⚠ same type
CORO1B p.Arg145Gln Uncertain significance ★ ⚠ same type
CORO1B p.Arg170Cys Uncertain significance ★ ⚠ same type

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/coro1b-p-pro301ala (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown