CORO1B — 100 ClinVar variants
All ClinVar germline CORO1B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 93 flagged for review →
2 Likely benign · 98 Uncertain significance
Full CORO1B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 93
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 57
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CORO1B p.Ala139Ser Uncertain significance Single submitter
- CORO1B p.Ala385Gly Uncertain significance Single submitter
- CORO1B p.Ala450Ser Uncertain significance Single submitter
- CORO1B p.Ala462Val Uncertain significance Single submitter
- CORO1B p.Arg134Gln Uncertain significance Single submitter
- CORO1B p.Arg170Cys Uncertain significance Single submitter
- CORO1B p.Arg207Gln Uncertain significance Single submitter
- CORO1B p.Arg225Trp Uncertain significance Single submitter
- CORO1B p.Arg245Gln Uncertain significance Single submitter
- CORO1B p.Arg293Gln Uncertain significance Single submitter
- CORO1B p.Arg317Leu Uncertain significance Single submitter
- CORO1B p.Arg325Trp Uncertain significance Single submitter
- CORO1B p.Arg408Gln Uncertain significance Single submitter
- CORO1B p.Arg408Leu Uncertain significance Single submitter
- CORO1B p.Arg409His Uncertain significance Single submitter
- CORO1B p.Arg446Lys Uncertain significance Single submitter
- CORO1B p.Arg473Cys Uncertain significance Single submitter
- CORO1B p.Asn155Ser Uncertain significance Single submitter
- CORO1B p.Asp23Asn Uncertain significance Single submitter
- CORO1B p.Asp472Asn Uncertain significance Single submitter
- CORO1B p.Asp95Asn Uncertain significance Single submitter
- CORO1B p.Cys195Arg Uncertain significance Single submitter
- CORO1B p.Glu299Ala Uncertain significance Single submitter
- CORO1B p.Glu454Asp Uncertain significance Single submitter
- CORO1B p.Gly326Ser Uncertain significance Single submitter
- CORO1B p.Gly369Ala Uncertain significance Single submitter
- CORO1B p.Gly369Arg Uncertain significance Single submitter
- CORO1B p.Gly382Arg Uncertain significance Single submitter
- CORO1B p.Gly442Ser Uncertain significance Single submitter
- CORO1B p.Gly448Arg Uncertain significance Single submitter
- CORO1B p.His305Tyr Uncertain significance Single submitter
- CORO1B p.Ile29Phe Uncertain significance Single submitter
- CORO1B p.Ile348Leu Uncertain significance Single submitter
- CORO1B p.Leu178Pro Uncertain significance Single submitter
- CORO1B p.Leu272Pro Uncertain significance Single submitter
- CORO1B p.Lys21Arg Uncertain significance Single submitter
- CORO1B p.Met242Ile Uncertain significance Single submitter
- CORO1B p.Met350Thr Uncertain significance Single submitter
- CORO1B p.Phe295Cys Uncertain significance Single submitter
- CORO1B p.Phe295Val Uncertain significance Single submitter
- CORO1B p.Pro113Leu Uncertain significance Single submitter
- CORO1B p.Pro301Ala Uncertain significance Single submitter
- CORO1B p.Ser102Trp Uncertain significance Single submitter
- CORO1B p.Ser280Thr Uncertain significance Single submitter
- CORO1B p.Ser399Asn Uncertain significance Single submitter
- CORO1B p.Ser413Pro Uncertain significance Single submitter
- CORO1B p.Ser413Thr Uncertain significance Single submitter
- CORO1B p.Ser66Thr Uncertain significance Single submitter
- CORO1B p.Thr309Met Uncertain significance Single submitter
- CORO1B p.Thr439Ile Uncertain significance Single submitter
- CORO1B p.Tyr294Asp Uncertain significance Single submitter
- CORO1B p.Val147Met Uncertain significance Single submitter
- CORO1B p.Val156Met Uncertain significance Single submitter
- CORO1B p.Val31Met Uncertain significance Single submitter
- CORO1B p.Val380Ala Uncertain significance Single submitter
- CORO1B p.Val456Met Uncertain significance Single submitter
- CORO1B p.Val78Met Uncertain significance Single submitter
Predictors split 36
The independent predictors disagree with each other — read with care.
- CORO1B p.Ala248Val Uncertain significance Single submitter
- CORO1B p.Arg145Gln Uncertain significance Single submitter
- CORO1B p.Arg206His Uncertain significance Single submitter
- CORO1B p.Arg222Gln Uncertain significance Single submitter
- CORO1B p.Arg225Gln Uncertain significance Single submitter
- CORO1B p.Arg343Cys Uncertain significance Single submitter
- CORO1B p.Arg343His Uncertain significance Single submitter
- CORO1B p.Arg402Gln Uncertain significance Single submitter
- CORO1B p.Arg402Trp Uncertain significance Single submitter
- CORO1B p.Arg408Trp Uncertain significance Single submitter
- CORO1B p.Arg409Cys Uncertain significance Single submitter
- CORO1B p.Arg416Trp Uncertain significance Single submitter
- CORO1B p.Arg483Cys Uncertain significance Single submitter
- CORO1B p.Arg483His Uncertain significance Single submitter
- CORO1B p.Asn187Ser Uncertain significance Single submitter
- CORO1B p.Asp177Glu Uncertain significance Single submitter
- CORO1B p.Gln24Glu Uncertain significance Single submitter
- CORO1B p.Gln470His Uncertain significance Single submitter
- CORO1B p.Gln9His Uncertain significance Single submitter
- CORO1B p.Gln9Lys Uncertain significance Single submitter
- CORO1B p.Glu375Lys Uncertain significance Single submitter
- CORO1B p.Gly101Ser Uncertain significance Single submitter
- CORO1B p.Leu389Arg Uncertain significance Single submitter
- CORO1B p.Leu453Pro Uncertain significance Single submitter
- CORO1B p.Leu63Val Uncertain significance Single submitter
- CORO1B p.Met457Arg Uncertain significance Single submitter
- CORO1B p.Met457Thr Uncertain significance Single submitter
- CORO1B p.Phe295Leu Uncertain significance Single submitter
- CORO1B p.Pro120Leu Uncertain significance Single submitter
- CORO1B p.Pro277Arg Uncertain significance Single submitter
- CORO1B p.Ser413Phe Uncertain significance Single submitter
- CORO1B p.Ser423Tyr Uncertain significance Single submitter
- CORO1B p.Thr279Ile Uncertain significance Single submitter
- CORO1B p.Thr309Ala Uncertain significance Single submitter
- CORO1B p.Thr68Met Uncertain significance Single submitter
- CORO1B p.Val85Ile Uncertain significance Single submitter
All CORO1B variants
Likely benign 2
- p.Ala139Thr Single submitter
- p.Ala49= Single submitter
Uncertain significance 98
- p.Ala139Ser Single submitter ⚠
- p.Ala248Val Single submitter ⚠
- p.Ala385Gly Single submitter ⚠
- p.Ala450Ser Single submitter ⚠
- p.Ala462Val Single submitter ⚠
- p.Arg134Gln Single submitter ⚠
- p.Arg145Gln Single submitter ⚠
- p.Arg170Cys Single submitter ⚠
- p.Arg206His Single submitter ⚠
- p.Arg207Gln Single submitter ⚠
- p.Arg222Gln Single submitter ⚠
- p.Arg225Gln Single submitter ⚠
- p.Arg225Trp Single submitter ⚠
- p.Arg241Gln Single submitter
- p.Arg245Gln Single submitter ⚠
- p.Arg293Gln Single submitter ⚠
- p.Arg317Leu Single submitter ⚠
- p.Arg325Trp Single submitter ⚠
- p.Arg343Cys Single submitter ⚠
- p.Arg343His Single submitter ⚠
- p.Arg402Gln Single submitter ⚠
- p.Arg402Trp Single submitter ⚠
- p.Arg408Gln Single submitter ⚠
- p.Arg408Leu Single submitter ⚠
- p.Arg408Trp Single submitter ⚠
- p.Arg409Cys Single submitter ⚠
- p.Arg409His Single submitter ⚠
- p.Arg416Trp Single submitter ⚠
- p.Arg446Lys Single submitter ⚠
- p.Arg473Cys Single submitter ⚠
- p.Arg473His Single submitter
- p.Arg483Cys Single submitter ⚠
- p.Arg483His Single submitter ⚠
- p.Asn155Ser Single submitter ⚠
- p.Asn187Ser Single submitter ⚠
- p.Asp177Glu Single submitter ⚠
- p.Asp23Asn Single submitter ⚠
- p.Asp472Asn Single submitter ⚠
- p.Asp95Asn Single submitter ⚠
- p.Cys195Arg Single submitter ⚠
- p.Gln24Glu Single submitter ⚠
- p.Gln470His Single submitter ⚠
- p.Gln9His Single submitter ⚠
- p.Gln9Lys Single submitter ⚠
- p.Glu299Ala Single submitter ⚠
- p.Glu375Lys Single submitter ⚠
- p.Glu454Asp Single submitter ⚠
- p.Gly101Ser Single submitter ⚠
- p.Gly326Ser Single submitter ⚠
- p.Gly369Ala Single submitter ⚠
- p.Gly369Arg Single submitter ⚠
- p.Gly382Arg Single submitter ⚠
- p.Gly442Ser Single submitter ⚠
- p.Gly448Arg Single submitter ⚠
- p.Gly487Trp Single submitter
- p.His305Tyr Single submitter ⚠
- p.Ile29Phe Single submitter ⚠
- p.Ile348Leu Single submitter ⚠
- p.Leu178Pro Single submitter ⚠
- p.Leu272Pro Single submitter ⚠
- p.Leu389Arg Single submitter ⚠
- p.Leu404Pro Single submitter
- p.Leu453Pro Single submitter ⚠
- p.Leu63Val Single submitter ⚠
- p.Lys21Arg Single submitter ⚠
- p.Met242Ile Single submitter ⚠
- p.Met319Ile Single submitter
- p.Met350Thr Single submitter ⚠
- p.Met457Arg Single submitter ⚠
- p.Met457Thr Single submitter ⚠
- p.Phe295Cys Single submitter ⚠
- p.Phe295Leu Single submitter ⚠
- p.Phe295Val Single submitter ⚠
- p.Pro113Leu Single submitter ⚠
- p.Pro120Leu Single submitter ⚠
- p.Pro277Arg Single submitter ⚠
- p.Pro301Ala Single submitter ⚠
- p.Ser102Trp Single submitter ⚠
- p.Ser280Thr Single submitter ⚠
- p.Ser399Asn Single submitter ⚠
- p.Ser413Phe Single submitter ⚠
- p.Ser413Pro Single submitter ⚠
- p.Ser413Thr Single submitter ⚠
- p.Ser423Tyr Single submitter ⚠
- p.Ser66Thr Single submitter ⚠
- p.Thr279Ile Single submitter ⚠
- p.Thr309Ala Single submitter ⚠
- p.Thr309Met Single submitter ⚠
- p.Thr439Ile Single submitter ⚠
- p.Thr68Met Single submitter ⚠
- p.Tyr294Asp Single submitter ⚠
- p.Val147Met Single submitter ⚠
- p.Val156Met Single submitter ⚠
- p.Val31Met Single submitter ⚠
- p.Val380Ala Single submitter ⚠
- p.Val456Met Single submitter ⚠
- p.Val78Met Single submitter ⚠
- p.Val85Ile Single submitter ⚠