Is CPN2 p.Trp458Arg (c.1372T>C) pathogenic?

CPN2 p.Trp458Arg (c.1372T>C) is classified Uncertain significance in CPN2 (ClinVar, Single submitter, 1 submitter; last evaluated 2022-01-26). AlphaMissense: likely benign (0.0728); Very rare (popmax 0.00266%, afr).

How common is CPN2 p.Trp458Arg (c.1372T>C) in the general population?

CPN2 p.Trp458Arg (c.1372T>C) is very rare (popmax 0.00266%, afr) (gnomAD).

What do computational predictors say about CPN2 p.Trp458Arg (c.1372T>C)?

AlphaMissense predicts likely benign (score 0.0728) — an in-silico prediction, not a clinical call.

CPN2 p.Trp458Arg

c.1372T>C · rs1712807908 · VCV2273410

Uncertain significance Single submitter

Classification

Uncertain significance

ClinVar

Review

Single submitter ★☆☆☆

ClinVar · 1 submitter

AlphaMissense

likely benign

0.0728 · ACMG-weighted

gnomAD v4.1

Rare

very rare (popmax 0.00266%, afr)

Missense predictors

0/3 damaging

AlphaMissense, REVEL, SaProt

Computational evidence

Protein change
AlphaMissense	0.0728	likely benign
REVEL	0.039	moderately benign-leaning
SaProt	LLR -5.50	tolerated
⇒ AlphaMissense, REVEL and SaProt all call this tolerated.
Splicing
SpliceAI	—	not assessed · no allele here is in the release
Constraint at this position
Conservation	phyloP 0.29	GERP -0.81
Regional constraint	o/e 0.92	unconstrained · MANE · 1,634 bp · p 0.047 · regional, not allelic
Overall
CADD	4.976	PHRED · no single calibrated threshold — expert panels disagree

ClinVar classifies this uncertain; the computational predictors unanimously lean tolerated — a triage signal, not a reclassification

AlphaMissense carries the ACMG weight for missense; REVEL and SaProt are independent agreement signals.

Population frequency

gnomAD v4.1 · exomes + genomes

Grpmax group 0.00266% African / African-American · 2/75,064 alleles

Filtering AF 0.000442% ClinGen BA1/BS1 input FAF95, joint · FAF99 0.000166%

Overall 0.000205% 3/1,461,526 alleles · very rare

Ancestry group	Frequency	1 in
African / African-Americangrpmax	0.00266%	37,532
Remaining individualsnot grpmax-eligible	0.0016%	62,502

Rarity supports pathogenicity (ACMG PM2); frequency above a disease-specific BA1/BS1 threshold argues against it. A variant frequent in one ancestry group can be near-absent in others, so a single global figure can mislead.

Variant & gene context

Gene: CPN2
Protein: p.Trp458Arg
Coding: c.1372T>C
MANE Select: NM_001080513
dbSNP: rs1712807908
Type: single nucleotide variant
Location: chr3:194341331 (GRCh38)
Gene constraint: LOEUF 1.831 · pLI 0.20 (gnomAD)
Structure: AlphaFold pLDDT 85.71

Full CPN2 gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Similar variants

CPN2 p.Leu14= Benign ★★ same type
CPN2 p.Ala19Val Uncertain significance ★ ⚠ same type
CPN2 p.Ala204Val Uncertain significance ★ ⚠ same type
CPN2 p.Ala351Val Uncertain significance ★ ⚠ same type
CPN2 p.Ala476Thr Uncertain significance ★ ⚠ same type
CPN2 p.Ala477Ser Uncertain significance ★ ⚠ same type
CPN2 p.Ala493Thr Uncertain significance ★ ⚠ same type
CPN2 p.Arg250Cys Uncertain significance ★ ⚠ same type

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/cpn2-p-trp458arg (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown