CPN2 — 90 ClinVar variants
All ClinVar germline CPN2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 85 flagged for review →
2 Benign · 4 Likely benign · 84 Uncertain significance
Full CPN2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 85
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 39
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CPN2 p.Ala476Thr Uncertain significance Single submitter
- CPN2 p.Ala477Ser Uncertain significance Single submitter
- CPN2 p.Ala493Thr Uncertain significance Single submitter
- CPN2 p.Arg250Cys Uncertain significance Single submitter
- CPN2 p.Arg416Trp Uncertain significance Single submitter
- CPN2 p.Arg449Trp Uncertain significance Single submitter
- CPN2 p.Asn203His Uncertain significance Single submitter
- CPN2 p.Asp415Asn Uncertain significance Single submitter
- CPN2 p.Cys424Arg Uncertain significance Single submitter
- CPN2 p.Cys481Gly Uncertain significance Single submitter
- CPN2 p.Gln158Glu Uncertain significance Single submitter
- CPN2 p.Gln196His Uncertain significance Single submitter
- CPN2 p.Gln496His Uncertain significance Single submitter
- CPN2 p.Gln516Arg Uncertain significance Single submitter
- CPN2 p.Glu134Lys Uncertain significance Single submitter
- CPN2 p.Glu337Lys Uncertain significance Single submitter
- CPN2 p.Glu461Lys Uncertain significance Single submitter
- CPN2 p.Glu487Lys Uncertain significance Single submitter
- CPN2 p.Gly394Ser Uncertain significance Single submitter
- CPN2 p.Gly544Arg Uncertain significance Single submitter
- CPN2 p.Gly94Arg Uncertain significance Single submitter
- CPN2 p.His143Asn Uncertain significance Single submitter
- CPN2 p.Leu150Ile Uncertain significance Single submitter
- CPN2 p.Leu160Gln Uncertain significance Single submitter
- CPN2 p.Met132Ile Uncertain significance Single submitter
- CPN2 p.Ser218Arg Uncertain significance Single submitter
- CPN2 p.Ser317Tyr Uncertain significance Single submitter
- CPN2 p.Ser361Phe Uncertain significance Single submitter
- CPN2 p.Ser367Thr Uncertain significance Single submitter
- CPN2 p.Ser479Arg Uncertain significance Single submitter
- CPN2 p.Ser60Leu Uncertain significance Single submitter
- CPN2 p.Thr114Ser Uncertain significance Single submitter
- CPN2 p.Thr482Ala Uncertain significance Single submitter
- CPN2 p.Trp458Arg Uncertain significance Single submitter
- CPN2 p.Tyr385His Uncertain significance Single submitter
- CPN2 p.Tyr483Cys Uncertain significance Single submitter
- CPN2 p.Val30Gly Uncertain significance Single submitter
- CPN2 p.Val340Ala Uncertain significance Single submitter
- CPN2 p.Val491Leu Uncertain significance Single submitter
Predictors split 46
The independent predictors disagree with each other — read with care.
- CPN2 p.Ala19Val Uncertain significance Single submitter
- CPN2 p.Ala204Val Uncertain significance Single submitter
- CPN2 p.Ala252Val Benign Single submitter
- CPN2 p.Ala351Val Uncertain significance Single submitter
- CPN2 p.Arg316Cys Uncertain significance Single submitter
- CPN2 p.Arg500Cys Uncertain significance Single submitter
- CPN2 p.Arg533Trp Uncertain significance Single submitter
- CPN2 p.Asn131Ile Uncertain significance Single submitter
- CPN2 p.Asn386Ser Uncertain significance Single submitter
- CPN2 p.Asn72Lys Uncertain significance Single submitter
- CPN2 p.Asp382Asn Uncertain significance Single submitter
- CPN2 p.Cys481Tyr Uncertain significance Single submitter
- CPN2 p.Gln433Glu Uncertain significance Single submitter
- CPN2 p.Gln433His Uncertain significance Single submitter
- CPN2 p.Glu103Lys Uncertain significance Single submitter
- CPN2 p.Glu134Asp Uncertain significance Single submitter
- CPN2 p.Glu231Lys Uncertain significance Single submitter
- CPN2 p.Gly307Val Uncertain significance Single submitter
- CPN2 p.His170Tyr Uncertain significance Single submitter
- CPN2 p.His311Tyr Uncertain significance Single submitter
- CPN2 p.Leu128Phe Uncertain significance Single submitter
- CPN2 p.Leu144Val Uncertain significance Single submitter
- CPN2 p.Leu164Pro Uncertain significance Single submitter
- CPN2 p.Leu180Val Uncertain significance Single submitter
- CPN2 p.Leu192Pro Uncertain significance Single submitter
- CPN2 p.Leu240Phe Uncertain significance Single submitter
- CPN2 p.Leu312Val Uncertain significance Single submitter
- CPN2 p.Leu349Phe Uncertain significance Single submitter
- CPN2 p.Leu534Phe Uncertain significance Single submitter
- CPN2 p.Phe223Leu Uncertain significance Single submitter
- CPN2 p.Phe261Val Uncertain significance Single submitter
- CPN2 p.Pro185Leu Uncertain significance Single submitter
- CPN2 p.Pro209Ser Uncertain significance Single submitter
- CPN2 p.Pro234Leu Uncertain significance Single submitter
- CPN2 p.Pro377Leu Uncertain significance Single submitter
- CPN2 p.Ser230Leu Uncertain significance Single submitter
- CPN2 p.Ser369Cys Uncertain significance Single submitter
- CPN2 p.Ser369Pro Uncertain significance Single submitter
- CPN2 p.Ser36Leu Uncertain significance Single submitter
- CPN2 p.Ser479Asn Uncertain significance Single submitter
- CPN2 p.Ser528Gly Uncertain significance Single submitter
- CPN2 p.Thr326Asn Uncertain significance Single submitter
- CPN2 p.Thr383Ile Uncertain significance Single submitter
- CPN2 p.Thr489Asn Uncertain significance Single submitter
- CPN2 p.Val279Ile Uncertain significance Single submitter
- CPN2 p.Val33Ala Uncertain significance Single submitter
All CPN2 variants
Benign 2
- p.Leu14= Multiple submitters
- p.Ala252Val Single submitter ⚠
Likely benign 4
- p.Ile55Val Single submitter
- p.Lys370Arg Single submitter
- p.Pro459Leu Single submitter
- p.Tyr50His Single submitter
Uncertain significance 84
- p.Ala19Val Single submitter ⚠
- p.Ala204Val Single submitter ⚠
- p.Ala351Val Single submitter ⚠
- p.Ala476Thr Single submitter ⚠
- p.Ala477Ser Single submitter ⚠
- p.Ala493Thr Single submitter ⚠
- p.Arg250Cys Single submitter ⚠
- p.Arg316Cys Single submitter ⚠
- p.Arg416Trp Single submitter ⚠
- p.Arg449Trp Single submitter ⚠
- p.Arg500Cys Single submitter ⚠
- p.Arg533Trp Single submitter ⚠
- p.Asn131Ile Single submitter ⚠
- p.Asn203His Single submitter ⚠
- p.Asn386Ser Single submitter ⚠
- p.Asn72Lys Single submitter ⚠
- p.Asp382Asn Single submitter ⚠
- p.Asp415Asn Single submitter ⚠
- p.Cys424Arg Single submitter ⚠
- p.Cys481Gly Single submitter ⚠
- p.Cys481Tyr Single submitter ⚠
- p.Gln158Glu Single submitter ⚠
- p.Gln196His Single submitter ⚠
- p.Gln433Glu Single submitter ⚠
- p.Gln433His Single submitter ⚠
- p.Gln496His Single submitter ⚠
- p.Gln516Arg Single submitter ⚠
- p.Glu103Lys Single submitter ⚠
- p.Glu134Asp Single submitter ⚠
- p.Glu134Lys Single submitter ⚠
- p.Glu231Lys Single submitter ⚠
- p.Glu337Lys Single submitter ⚠
- p.Glu461Lys Single submitter ⚠
- p.Glu487Lys Single submitter ⚠
- p.Gly307Val Single submitter ⚠
- p.Gly394Ser Single submitter ⚠
- p.Gly544Arg Single submitter ⚠
- p.Gly94Arg Single submitter ⚠
- p.His143Asn Single submitter ⚠
- p.His170Tyr Single submitter ⚠
- p.His311Tyr Single submitter ⚠
- p.Leu128Phe Single submitter ⚠
- p.Leu144Val Single submitter ⚠
- p.Leu150Ile Single submitter ⚠
- p.Leu160Gln Single submitter ⚠
- p.Leu164Pro Single submitter ⚠
- p.Leu180Val Single submitter ⚠
- p.Leu192Pro Single submitter ⚠
- p.Leu240Phe Single submitter ⚠
- p.Leu312Val Single submitter ⚠
- p.Leu349Phe Single submitter ⚠
- p.Leu534Phe Single submitter ⚠
- p.Met132Ile Single submitter ⚠
- p.Phe223Leu Single submitter ⚠
- p.Phe261Val Single submitter ⚠
- p.Pro185Leu Single submitter ⚠
- p.Pro209Ser Single submitter ⚠
- p.Pro234Leu Single submitter ⚠
- p.Pro377Leu Single submitter ⚠
- p.Ser218Arg Single submitter ⚠
- p.Ser230Leu Single submitter ⚠
- p.Ser317Tyr Single submitter ⚠
- p.Ser361Phe Single submitter ⚠
- p.Ser367Thr Single submitter ⚠
- p.Ser369Cys Single submitter ⚠
- p.Ser369Pro Single submitter ⚠
- p.Ser36Leu Single submitter ⚠
- p.Ser479Arg Single submitter ⚠
- p.Ser479Asn Single submitter ⚠
- p.Ser528Gly Single submitter ⚠
- p.Ser60Leu Single submitter ⚠
- p.Thr114Ser Single submitter ⚠
- p.Thr326Asn Single submitter ⚠
- p.Thr383Ile Single submitter ⚠
- p.Thr482Ala Single submitter ⚠
- p.Thr489Asn Single submitter ⚠
- p.Trp458Arg Single submitter ⚠
- p.Tyr385His Single submitter ⚠
- p.Tyr483Cys Single submitter ⚠
- p.Val279Ile Single submitter ⚠
- p.Val30Gly Single submitter ⚠
- p.Val33Ala Single submitter ⚠
- p.Val340Ala Single submitter ⚠
- p.Val491Leu Single submitter ⚠