CRP p.Pro43=
c.129G>A · rs36061058 · VCV791614
Benign
Multiple submitters
Classification
Benign
ClinVar
Review
Multiple submitters ★★☆☆
ClinVar · 2 submitters
gnomAD v4.1
Rare
low-frequency (popmax 1.64%, afr)
Computational evidence
| Protein change | ||
| Missense predictors do not apply to this variant type; conservation carries the signal. | ||
| Splicing | ||
| SpliceAI | — | not assessed · no allele here is in the release |
|---|---|---|
| Constraint at this position | ||
| Conservation | phyloP -2.3 | GERP -2.7 |
| Overall | ||
| CADD | 9.893 | PHRED · no single calibrated threshold — expert panels disagree |
Population frequency
gnomAD v4.1 · exomes + genomes
Grpmax group
1.64%
African / African-American · 1,232/74,932 alleles
Filtering AF
1.57%
ClinGen BA1/BS1 input
FAF95, joint · FAF99 1.54%
Overall
0.0901%
1,454/1,613,324 alleles · low-frequency
| Ancestry group | Frequency | 1 in |
|---|---|---|
| African / African-Americangrpmax | 1.64% | 61 |
| Admixed American | 0.142% | 706 |
| Remaining individualsnot grpmax-eligible | 0.112% | 893 |
| Middle Eastern | 0.033% | 3,031 |
| European (non-Finnish) | 0.00517% | 19,344 |
| South Asian | 0.00439% | 22,762 |
Rarity supports pathogenicity (ACMG PM2); frequency above a disease-specific BA1/BS1 threshold argues against it. A variant frequent in one ancestry group can be near-absent in others, so a single global figure can mislead.
Variant & gene context
- Gene
- CRP
- Protein
- p.Pro43=
- Coding
- c.129G>A
- MANE Select
- NM_000567
- dbSNP
- rs36061058
- Type
- single nucleotide variant
- Location
- chr1:159714071 (GRCh38)
- Gene constraint
- LOEUF 1.932 · pLI <0.01 (gnomAD)
- Structure
- AlphaFold pLDDT 94.24 · 24 PDB
- Residue 43
- the pentraxin (ptx) domain
Similar variants
- CRP p.Thr35= Benign ★★ same type
- CRP p.Ala207Pro Uncertain significance ★ ⚠ same type
- CRP p.Ala50Gly Uncertain significance ★ ⚠ same type
- CRP p.Arg136Lys Uncertain significance ★ ⚠ same type
- CRP p.Glu156Lys Uncertain significance ★ ⚠ same type
- CRP p.Glu188Asp Uncertain significance ★ ⚠ same type
- CRP p.Gly166Arg Uncertain significance ★ ⚠ same type
- CRP p.Ile192Met Uncertain significance ★ ⚠ same type
Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →
Cite Sugi Variant
Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/crp-p-pro43 (accessed [today's date]).
Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown