CRP — 33 ClinVar variants
All ClinVar germline CRP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 21 flagged for review →
2 Benign · 9 Likely benign · 22 Uncertain significance
Full CRP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 21
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CRP p.Ala50Gly Uncertain significance Single submitter
- CRP p.Arg136Lys Uncertain significance Single submitter
- CRP p.Glu188Asp Uncertain significance Single submitter
- CRP p.Gly166Arg Uncertain significance Single submitter
- CRP p.Ile192Met Uncertain significance Single submitter
- CRP p.Leu101Ser Uncertain significance Single submitter
- CRP p.Leu101Val Uncertain significance Single submitter
- CRP p.Lys140Arg Uncertain significance Single submitter
- CRP p.Ser117Thr Uncertain significance Single submitter
- CRP p.Ser199Asn Uncertain significance Single submitter
- CRP p.Ser63Leu Uncertain significance Single submitter
- CRP p.Ser71Leu Uncertain significance Single submitter
- CRP p.Ser71Trp Uncertain significance Single submitter
- CRP p.Val216Met Uncertain significance Single submitter
-
CRP p.Glu119Asp
Uncertain significance
No assertion criteria
CRP-related disorder
Predictors split 6
The independent predictors disagree with each other — read with care.
- CRP p.Ala207Pro Uncertain significance Single submitter
- CRP p.Glu156Lys Uncertain significance Single submitter
- CRP p.Phe102Leu Uncertain significance Single submitter
- CRP p.Thr191Pro Uncertain significance Single submitter
- CRP p.Thr59Met Uncertain significance Single submitter
-
CRP p.Ile174Thr
Uncertain significance
No assertion criteria
CRP-related disorder
All CRP variants
Likely benign 9
- p.His113= Single submitter
- p.Leu153= Single submitter
- p.Leu184= Single submitter
- p.Ser120= Single submitter
- p.Ser14= Single submitter
- p.Val129= Single submitter
- p.Val212= Single submitter
- p.Val212Ala Single submitter
- p.Thr45Met No assertion criteria CRP-related disorder
Uncertain significance 22
- p.Ala207Pro Single submitter ⚠
- p.Ala50Gly Single submitter ⚠
- p.Arg136Lys Single submitter ⚠
- p.Glu156Lys Single submitter ⚠
- p.Glu188Asp Single submitter ⚠
- p.Gly166Arg Single submitter ⚠
- p.Ile192Met Single submitter ⚠
- p.Leu101Ser Single submitter ⚠
- p.Leu101Val Single submitter ⚠
- p.Lys140Arg Single submitter ⚠
- p.Phe102Leu Single submitter ⚠
- p.Ser117Thr Single submitter ⚠
- p.Ser199Asn Single submitter ⚠
- p.Ser63Leu Single submitter ⚠
- p.Ser71Leu Single submitter ⚠
- p.Ser71Trp Single submitter ⚠
- p.Thr191Pro Single submitter ⚠
- p.Thr59Met Single submitter ⚠
- p.Val216Met Single submitter ⚠
- c.*1082G>A No assertion criteria Inflammation
- p.Glu119Asp No assertion criteria CRP-related disorder ⚠
- p.Ile174Thr No assertion criteria CRP-related disorder ⚠