Is F8 p.His651Pro (c.1952A>C) pathogenic?

F8 p.His651Pro (c.1952A>C) is classified Likely pathogenic in F8 (ClinVar, Single submitter, 1 submitter; last evaluated 2018-04-03). AlphaMissense: ambiguous (0.373); Absent from gnomAD v4.1.

How common is F8 p.His651Pro (c.1952A>C) in the general population?

F8 p.His651Pro (c.1952A>C) is absent from gnomAD v4.1 (gnomAD).

What do computational predictors say about F8 p.His651Pro (c.1952A>C)?

AlphaMissense predicts ambiguous (score 0.373) — an in-silico prediction, not a clinical call.

F8 p.His651Pro

c.1952A>C · rs1569559758 · VCV618639

Likely pathogenic Single submitter

Classification

Likely pathogenic

ClinVar

Review

Single submitter ★☆☆☆

ClinVar · 1 submitter

AlphaMissense

ambiguous

0.373 · ACMG-weighted

gnomAD v4.1

Absent

absent from gnomAD v4.1

Missense predictors

2/2 damaging

REVEL, SaProt · AlphaMissense indeterminate

Computational evidence

Protein change
AlphaMissense	0.373	ambiguous
REVEL	0.766	pathogenic-leaning
SaProt	LLR -10.44	damaging
⇒ REVEL and SaProt both call this damaging; AlphaMissense is indeterminate.
Splicing
SpliceAI	—	not assessed · no allele here is in the release
Constraint at this position
Conservation	phyloP 7.6	GERP 1.4, phastCons 1
Regional constraint	o/e 0.74	unconstrained · MANE · 38 kb · p 2.6e-06 · regional, not allelic
Overall
CADD	24.4	PHRED · no single calibrated threshold — expert panels disagree

AlphaMissense carries the ACMG weight for missense; REVEL and SaProt are independent agreement signals.

Population frequency

gnomAD v4.1 · exomes + genomes

Absent from gnomAD v4.1. Not observed in any sequenced alleles — a rarity signal (ACMG PM2-supporting), not evidence of pathogenicity on its own.

Variant & gene context

Gene: F8
Protein: p.His651Pro
Coding: c.1952A>C
MANE Select: NM_000132
dbSNP: rs1569559758
Type: single nucleotide variant
Location: chrX:154947859 (GRCh38)
Structure: AlphaFold pLDDT 61.20 · 29 PDB
Residue 651: the plastocyanin-like 4 domain; a β-strand; the f5/8 type a 2 domain

Full F8 gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Similar variants

F8 c.6429+2T>A Pathogenic ★★★ same type
F8 p.Ala111Thr Likely pathogenic ★★★ same type
F8 p.Ala2220Pro Pathogenic ★★★ same type
F8 p.Ala415Asp Likely pathogenic ★★★ same type
F8 p.Ala415Val Pathogenic ★★★ ⚠ same type
F8 p.Arg1768His Pathogenic ★★★ ⚠ same type
F8 p.Arg1800His Pathogenic ★★★ same type
F8 p.Arg2016Trp Pathogenic ★★★ same type

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/f8-p-his651pro (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown