Sugi Variant

Sugi Variant/F8

F8 — 1231 ClinVar variants

All ClinVar germline F8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 571 flagged for review →

353 Pathogenic · 42 Pathogenic/Likely pathogenic · 257 Likely pathogenic · 51 Conflicting · 35 Benign · 12 Benign/Likely benign · 90 Likely benign · 391 Uncertain significance

Full F8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 571

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 88

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 28

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 244

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 244

Predictors split 211

The independent predictors disagree with each other — read with care. · showing the 150 best-reviewed of 211

All F8 variants

Pathogenic 353

Showing the top 300 by review status; the full set is in the sitemap.

Pathogenic/Likely pathogenic 42

Likely pathogenic 257

Conflicting classifications of pathogenicity 51

Benign 35

Benign/Likely benign 12

Likely benign 90

Uncertain significance 391

Showing the top 300 by review status; the full set is in the sitemap.