FOS p.Ser14=
c.42C>A · rs1353278087 · VCV748024
Likely benign
Single submitter
Classification
Likely benign
ClinVar
Review
Single submitter ★☆☆☆
ClinVar · 1 submitter
gnomAD v4.1
Absent
absent from gnomAD v4.1
Computational evidence
| Protein change | ||
| Missense predictors do not apply to this variant type; conservation carries the signal. | ||
| Splicing | ||
| SpliceAI | — | not assessed · no allele here is in the release |
|---|---|---|
| Constraint at this position | ||
| Conservation | phyloP 0.01 | GERP -1.6, phastCons 0.32 |
| Overall | ||
| CADD | 10.49 | PHRED · no single calibrated threshold — expert panels disagree |
Population frequency
gnomAD v4.1 · exomes + genomes
Absent from gnomAD v4.1. Not observed in any sequenced alleles — a rarity signal (ACMG PM2-supporting), not evidence of pathogenicity on its own.
Variant & gene context
- Gene
- FOS
- Protein
- p.Ser14=
- Coding
- c.42C>A
- MANE Select
- NM_005252
- dbSNP
- rs1353278087
- Type
- single nucleotide variant
- Location
- chr14:75279024 (GRCh38)
- Gene constraint
- LOEUF 0.581 · pLI 0.87 (gnomAD)
- Structure
- AlphaFold pLDDT 58.48 · 3 PDB
Similar variants
- FOS p.Lys176Asn Benign/Likely benign ★★ ⚠ same type
- FOS p.Pro233= Likely benign ★★ same type
- FOS p.Pro233Ala Likely benign ★★ same type
- FOS p.Thr63= Benign ★★ same type
- FOS p.Arg155Cys Likely pathogenic ★ same type
- FOS p.Ala103Val Uncertain significance ★ ⚠ same type
- FOS p.Ala184Asp Uncertain significance ★ ⚠ same type
- FOS p.Ala203Val Uncertain significance ★ ⚠ same type
Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →
Cite Sugi Variant
Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/fos-p-ser14 (accessed [today's date]).
Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown