FOS — 42 ClinVar variants
All ClinVar germline FOS variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 29 flagged for review →
1 Likely pathogenic · 3 Benign · 1 Benign/Likely benign · 8 Likely benign · 29 Uncertain significance
Full FOS gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 29
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FOS p.Ala103Val Uncertain significance Single submitter
- FOS p.Ala203Val Uncertain significance Single submitter
- FOS p.Arg108Gly Uncertain significance Single submitter
- FOS p.Arg287Cys Uncertain significance Single submitter
- FOS p.Arg287His Uncertain significance Single submitter
- FOS p.Asn45Ser Uncertain significance Single submitter
- FOS p.Asn59Lys Uncertain significance Single submitter
- FOS p.Asp246Glu Uncertain significance Single submitter
- FOS p.Gln121Arg Uncertain significance Single submitter
- FOS p.Glu138Ala Uncertain significance Single submitter
- FOS p.Glu182Lys Uncertain significance Single submitter
- FOS p.Glu215Asp Uncertain significance Single submitter
- FOS p.Gly118Val Uncertain significance Single submitter
- FOS p.Lys176Gln Uncertain significance Single submitter
- FOS p.Lys250Glu Uncertain significance Single submitter
- FOS p.Met115Val Uncertain significance Single submitter
- FOS p.Pro228Ala Uncertain significance Single submitter
- FOS p.Pro251Leu Uncertain significance Single submitter
- FOS p.Pro255Ser Uncertain significance Single submitter
- FOS p.Pro95His Uncertain significance Single submitter
- FOS p.Ser362Thr Uncertain significance Single submitter
- FOS p.Thr114Asn Uncertain significance Single submitter
- FOS p.Val98Ala Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- FOS p.Lys176Asn Benign/Likely benign Multiple submitters
- FOS p.Ala184Asp Uncertain significance Single submitter
- FOS p.Leu323Met Uncertain significance Single submitter
- FOS p.Leu323Pro Uncertain significance Single submitter
- FOS p.Phe343Val Uncertain significance Single submitter
- FOS p.Val327Leu Uncertain significance Single submitter
All FOS variants
Likely pathogenic 1
- p.Arg155Cys Single submitter osteopetrosis
Benign/Likely benign 1
- p.Lys176Asn Multiple submitters ⚠
Likely benign 8
- p.Pro233= Multiple submitters
- p.Pro233Ala Multiple submitters
- p.Arg159= Single submitter
- p.Glu304= Single submitter
- p.Ile123Val Single submitter
- p.Leu132= Single submitter
- p.Leu161= Single submitter
- p.Ser14= Single submitter
Uncertain significance 29
- p.Ala103Val Single submitter ⚠
- p.Ala184Asp Single submitter ⚠
- p.Ala203Val Single submitter ⚠
- p.Arg108Gly Single submitter ⚠
- p.Arg287Cys Single submitter ⚠
- p.Arg287His Single submitter ⚠
- p.Asn45Ser Single submitter ⚠
- p.Asn59Lys Single submitter ⚠
- p.Asp246Glu Single submitter ⚠
- p.Gln121Arg Single submitter ⚠
- p.Glu138Ala Single submitter ⚠
- p.Glu182Lys Single submitter ⚠
- p.Glu215Asp Single submitter ⚠
- p.Gly118Val Single submitter ⚠
- p.Leu323Met Single submitter ⚠
- p.Leu323Pro Single submitter ⚠
- p.Lys176Gln Single submitter ⚠
- p.Lys250Glu Single submitter ⚠
- p.Met115Val Single submitter ⚠
- p.Phe343Val Single submitter ⚠
- p.Pro228Ala Single submitter ⚠
- p.Pro251Leu Single submitter ⚠
- p.Pro255Ser Single submitter ⚠
- p.Pro71Arg Single submitter
- p.Pro95His Single submitter ⚠
- p.Ser362Thr Single submitter ⚠
- p.Thr114Asn Single submitter ⚠
- p.Val327Leu Single submitter ⚠
- p.Val98Ala Single submitter ⚠