AAMP — 51 ClinVar variants
All ClinVar germline AAMP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 50 flagged for review →
51 Uncertain significance
Full AAMP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 50
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 37
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- AAMP p.Ala116Gly Uncertain significance Single submitter
- AAMP p.Ala289Val Uncertain significance Single submitter
- AAMP p.Ala304Val Uncertain significance Single submitter
- AAMP p.Arg222Gln Uncertain significance Single submitter
- AAMP p.Arg397Gln Uncertain significance Single submitter
- AAMP p.Asp123Asn Uncertain significance Single submitter
- AAMP p.Asp81Asn Uncertain significance Single submitter
- AAMP p.Gln162Lys Uncertain significance Single submitter
- AAMP p.Gln212Pro Uncertain significance Single submitter
- AAMP p.Gln70Arg Uncertain significance Single submitter
- AAMP p.Glu181Asp Uncertain significance Single submitter
- AAMP p.Glu53Gly Uncertain significance Single submitter
- AAMP p.Glu71Lys Uncertain significance Single submitter
- AAMP p.Gly110Trp Uncertain significance Single submitter
- AAMP p.Gly192Ala Uncertain significance Single submitter
- AAMP p.His251Arg Uncertain significance Single submitter
- AAMP p.Leu351Arg Uncertain significance Single submitter
- AAMP p.Met47Ile Uncertain significance Single submitter
- AAMP p.Pro14Arg Uncertain significance Single submitter
- AAMP p.Pro15Ala Uncertain significance Single submitter
- AAMP p.Pro15Gln Uncertain significance Single submitter
- AAMP p.Pro15Thr Uncertain significance Single submitter
- AAMP p.Pro300Thr Uncertain significance Single submitter
- AAMP p.Pro307Leu Uncertain significance Single submitter
- AAMP p.Pro38Leu Uncertain significance Single submitter
- AAMP p.Pro38Ser Uncertain significance Single submitter
- AAMP p.Ser155Arg Uncertain significance Single submitter
- AAMP p.Ser20Gly Uncertain significance Single submitter
- AAMP p.Ser359Leu Uncertain significance Single submitter
- AAMP p.Thr394Ile Uncertain significance Single submitter
- AAMP p.Thr400Lys Uncertain significance Single submitter
- AAMP p.Thr400Met Uncertain significance Single submitter
- AAMP p.Trp161Arg Uncertain significance Single submitter
- AAMP p.Val118Leu Uncertain significance Single submitter
- AAMP p.Val252Ile Uncertain significance Single submitter
- AAMP p.Val382Met Uncertain significance Single submitter
- AAMP p.Val74Phe Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- AAMP p.Ala424Val Uncertain significance Single submitter
- AAMP p.Arg120Trp Uncertain significance Single submitter
- AAMP p.Arg352Gly Uncertain significance Single submitter
- AAMP p.Arg352Lys Uncertain significance Single submitter
- AAMP p.Arg383Cys Uncertain significance Single submitter
- AAMP p.Arg434Cys Uncertain significance Single submitter
- AAMP p.Gln246Pro Uncertain significance Single submitter
- AAMP p.Gly380Ser Uncertain significance Single submitter
- AAMP p.Lys209Gln Uncertain significance Single submitter
- AAMP p.Phe211Cys Uncertain significance Single submitter
- AAMP p.Pro249Arg Uncertain significance Single submitter
- AAMP p.Pro432Ser Uncertain significance Single submitter
- AAMP p.Thr348Met Uncertain significance Single submitter
All AAMP variants
Uncertain significance 51
- p.Ala116Gly Single submitter ⚠
- p.Ala289Val Single submitter ⚠
- p.Ala304Val Single submitter ⚠
- p.Ala424Val Single submitter ⚠
- p.Arg120Trp Single submitter ⚠
- p.Arg222Gln Single submitter ⚠
- p.Arg352Gly Single submitter ⚠
- p.Arg352Lys Single submitter ⚠
- p.Arg383Cys Single submitter ⚠
- p.Arg397Gln Single submitter ⚠
- p.Arg434Cys Single submitter ⚠
- p.Asp123Asn Single submitter ⚠
- p.Asp405Asn Single submitter
- p.Asp81Asn Single submitter ⚠
- p.Gln162Lys Single submitter ⚠
- p.Gln212Pro Single submitter ⚠
- p.Gln246Pro Single submitter ⚠
- p.Gln70Arg Single submitter ⚠
- p.Glu181Asp Single submitter ⚠
- p.Glu53Gly Single submitter ⚠
- p.Glu71Lys Single submitter ⚠
- p.Gly110Trp Single submitter ⚠
- p.Gly192Ala Single submitter ⚠
- p.Gly380Ser Single submitter ⚠
- p.His251Arg Single submitter ⚠
- p.Leu351Arg Single submitter ⚠
- p.Lys209Gln Single submitter ⚠
- p.Met47Ile Single submitter ⚠
- p.Phe211Cys Single submitter ⚠
- p.Pro14Arg Single submitter ⚠
- p.Pro15Ala Single submitter ⚠
- p.Pro15Gln Single submitter ⚠
- p.Pro15Thr Single submitter ⚠
- p.Pro249Arg Single submitter ⚠
- p.Pro300Thr Single submitter ⚠
- p.Pro307Leu Single submitter ⚠
- p.Pro38Leu Single submitter ⚠
- p.Pro38Ser Single submitter ⚠
- p.Pro432Ser Single submitter ⚠
- p.Ser155Arg Single submitter ⚠
- p.Ser20Gly Single submitter ⚠
- p.Ser359Leu Single submitter ⚠
- p.Thr348Met Single submitter ⚠
- p.Thr394Ile Single submitter ⚠
- p.Thr400Lys Single submitter ⚠
- p.Thr400Met Single submitter ⚠
- p.Trp161Arg Single submitter ⚠
- p.Val118Leu Single submitter ⚠
- p.Val252Ile Single submitter ⚠
- p.Val382Met Single submitter ⚠
- p.Val74Phe Single submitter ⚠