Sugi Variant

Sugi Variant/ABCC2

ABCC2 — 1241 ClinVar variants

All ClinVar germline ABCC2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 358 flagged for review →

108 Pathogenic · 24 Pathogenic/Likely pathogenic · 47 Likely pathogenic · 84 Conflicting · 78 Benign · 15 Benign/Likely benign · 532 Likely benign · 353 Uncertain significance

Full ABCC2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 358

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 15

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 182

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 182

Predictors split 161

The independent predictors disagree with each other — read with care. · showing the 150 best-reviewed of 161

All ABCC2 variants

Pathogenic 108

Pathogenic/Likely pathogenic 24

Likely pathogenic 47

Conflicting classifications of pathogenicity 84

Benign 78

Benign/Likely benign 15

Likely benign 532

Showing the top 300 by review status; the full set is in the sitemap.

Uncertain significance 353

Showing the top 300 by review status; the full set is in the sitemap.