ABCC4 — 183 ClinVar variants
All ClinVar germline ABCC4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 142 flagged for review →
24 Benign · 4 Benign/Likely benign · 19 Likely benign · 136 Uncertain significance
Full ABCC4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 142
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 80
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ABCC4 p.Ala1282Thr Uncertain significance Multiple submitters
- ABCC4 p.Ala1324Thr Uncertain significance Multiple submitters
- ABCC4 p.Tyr788Cys Uncertain significance Multiple submitters
- ABCC4 p.Ala224Val Uncertain significance Single submitter
- ABCC4 p.Ala227Ser Uncertain significance Single submitter
- ABCC4 p.Ala266Pro Uncertain significance Single submitter
- ABCC4 p.Ala422Val Uncertain significance Single submitter
- ABCC4 p.Ala673Val Uncertain significance Single submitter
- ABCC4 p.Ala709Thr Uncertain significance Single submitter
- ABCC4 p.Ala75Thr Uncertain significance Single submitter
- ABCC4 p.Ala859Val Uncertain significance Single submitter
- ABCC4 p.Arg398His Uncertain significance Single submitter
- ABCC4 p.Arg824His Uncertain significance Single submitter
- ABCC4 p.Arg897Gln Uncertain significance Single submitter
- ABCC4 p.Arg897Gly Uncertain significance Single submitter
- ABCC4 p.Arg915Gln Uncertain significance Single submitter
- ABCC4 p.Arg915Trp Uncertain significance Single submitter
- ABCC4 p.Asn1134Ser Uncertain significance Single submitter
- ABCC4 p.Asn1312Ser Uncertain significance Single submitter
- ABCC4 p.Asn544Lys Uncertain significance Single submitter
- ABCC4 p.Asn703Tyr Uncertain significance Single submitter
- ABCC4 p.Asn823Ile Uncertain significance Single submitter
- ABCC4 p.Asp516Tyr Uncertain significance Single submitter
- ABCC4 p.Asp932Gly Uncertain significance Single submitter
- ABCC4 p.Gln109Arg Uncertain significance Single submitter
- ABCC4 p.Gln397Arg Uncertain significance Single submitter
- ABCC4 p.Gln999Pro Uncertain significance Single submitter
- ABCC4 p.Glu1004Ala Uncertain significance Single submitter
- ABCC4 p.Glu1123Lys Uncertain significance Single submitter
- ABCC4 p.Gly1078Arg Uncertain significance Single submitter
- ABCC4 p.Gly445Ser Uncertain significance Single submitter
- ABCC4 p.Gly467Arg Uncertain significance Single submitter
- ABCC4 p.Gly487Glu Uncertain significance Single submitter
- ABCC4 p.Gly615Glu Uncertain significance Single submitter
- ABCC4 p.Gly62Arg Uncertain significance Single submitter
- ABCC4 p.His1305Tyr Uncertain significance Single submitter
- ABCC4 p.His583Asn Uncertain significance Single submitter
- ABCC4 p.His583Tyr Uncertain significance Single submitter
- ABCC4 p.Ile1199Val Uncertain significance Single submitter
- ABCC4 p.Ile1238Val Uncertain significance Single submitter
- ABCC4 p.Ile1320Thr Uncertain significance Single submitter
- ABCC4 p.Ile280Thr Uncertain significance Single submitter
- ABCC4 p.Ile780Lys Uncertain significance Single submitter
- ABCC4 p.Ile818Val Uncertain significance Single submitter
- ABCC4 p.Leu1019Val Uncertain significance Single submitter
- ABCC4 p.Leu1061Val Uncertain significance Single submitter
- ABCC4 p.Leu146Phe Uncertain significance Single submitter
- ABCC4 p.Leu719Phe Uncertain significance Single submitter
- ABCC4 p.Lys1265Glu Uncertain significance Single submitter
- ABCC4 p.Lys1294Glu Uncertain significance Single submitter
- ABCC4 p.Met1131Val Uncertain significance Single submitter
- ABCC4 p.Phe485Val Uncertain significance Single submitter
- ABCC4 p.Phe714Leu Uncertain significance Single submitter
- ABCC4 p.Pro10Arg Uncertain significance Single submitter
- ABCC4 p.Pro1121Leu Uncertain significance Single submitter
- ABCC4 p.Pro12Leu Uncertain significance Single submitter
- ABCC4 p.Pro1315Leu Uncertain significance Single submitter
- ABCC4 p.Pro642Leu Uncertain significance Single submitter
- ABCC4 p.Ser1316Leu Uncertain significance Single submitter
- ABCC4 p.Ser199Pro Uncertain significance Single submitter
- ABCC4 p.Ser294Pro Uncertain significance Single submitter
- ABCC4 p.Ser313Arg Uncertain significance Single submitter
- ABCC4 p.Ser396Ala Uncertain significance Single submitter
- ABCC4 p.Ser570Asn Uncertain significance Single submitter
- ABCC4 p.Ser570Ile Uncertain significance Single submitter
- ABCC4 p.Thr1077Ser Uncertain significance Single submitter
- ABCC4 p.Thr1204Met Uncertain significance Single submitter
- ABCC4 p.Thr281Ser Uncertain significance Single submitter
- ABCC4 p.Thr885Met Uncertain significance Single submitter
- ABCC4 p.Thr895Ala Uncertain significance Single submitter
- ABCC4 p.Tyr1259Asp Uncertain significance Single submitter
- ABCC4 p.Tyr704Cys Uncertain significance Single submitter
- ABCC4 p.Val1071Ile Uncertain significance Single submitter
- ABCC4 p.Val1246Leu Uncertain significance Single submitter
- ABCC4 p.Val140Met Uncertain significance Single submitter
- ABCC4 p.Val279Ile Uncertain significance Single submitter
- ABCC4 p.Val469Asp Uncertain significance Single submitter
- ABCC4 p.Val94Ala Uncertain significance Single submitter
- ABCC4 p.Val963Ile Uncertain significance Single submitter
-
ABCC4 p.Arg891Leu
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 62
The independent predictors disagree with each other — read with care.
- ABCC4 p.Leu238Phe Uncertain significance Multiple submitters
- ABCC4 p.Thr1142Met Benign/Likely benign Multiple submitters
- ABCC4 p.Ala1149Gly Uncertain significance Single submitter
- ABCC4 p.Ala134Gly Uncertain significance Single submitter
- ABCC4 p.Ala567Val Uncertain significance Single submitter
- ABCC4 p.Arg180Cys Uncertain significance Single submitter
- ABCC4 p.Arg180His Uncertain significance Single submitter
- ABCC4 p.Arg474Gly Uncertain significance Single submitter
- ABCC4 p.Arg82Ser Uncertain significance Single submitter
- ABCC4 p.Arg879Trp Uncertain significance Single submitter
- ABCC4 p.Arg951Cys Uncertain significance Single submitter
- ABCC4 p.Arg951His Uncertain significance Single submitter
- ABCC4 p.Asn17Lys Uncertain significance Single submitter
- ABCC4 p.Asn203His Uncertain significance Single submitter
- ABCC4 p.Asn816His Uncertain significance Single submitter
- ABCC4 p.Asp51Tyr Uncertain significance Single submitter
- ABCC4 p.Cys579Gly Uncertain significance Single submitter
- ABCC4 p.Gln481Leu Uncertain significance Single submitter
- ABCC4 p.Gln518His Uncertain significance Single submitter
- ABCC4 p.Gln595Pro Uncertain significance Single submitter
- ABCC4 p.Glu1095Lys Uncertain significance Single submitter
- ABCC4 p.Glu1145Gly Uncertain significance Single submitter
- ABCC4 p.Glu1266Lys Uncertain significance Single submitter
- ABCC4 p.Glu1280Lys Uncertain significance Single submitter
- ABCC4 p.Glu568Lys Uncertain significance Single submitter
- ABCC4 p.Glu639Lys Uncertain significance Single submitter
- ABCC4 p.Glu688Asp Likely benign Single submitter
- ABCC4 p.Glu757Lys Benign Single submitter
- ABCC4 p.Gly1129Ala Uncertain significance Single submitter
- ABCC4 p.Gly187Trp Benign Single submitter
- ABCC4 p.His1299Arg Uncertain significance Single submitter
- ABCC4 p.Ile1073Val Uncertain significance Single submitter
- ABCC4 p.Ile233Met Uncertain significance Single submitter
- ABCC4 p.Ile578Val Uncertain significance Single submitter
- ABCC4 p.Leu1162Ile Uncertain significance Single submitter
- ABCC4 p.Leu342Phe Uncertain significance Single submitter
- ABCC4 p.Lys304Asn Benign Single submitter
- ABCC4 p.Lys36Glu Uncertain significance Single submitter
- ABCC4 p.Lys509Thr Uncertain significance Single submitter
- ABCC4 p.Met44Ile Uncertain significance Single submitter
- ABCC4 p.Phe620Leu Uncertain significance Single submitter
- ABCC4 p.Phe63Leu Uncertain significance Single submitter
- ABCC4 p.Phe716Tyr Uncertain significance Single submitter
- ABCC4 p.Phe877Ser Uncertain significance Single submitter
- ABCC4 p.Ser1241Gly Uncertain significance Single submitter
- ABCC4 p.Ser328Asn Uncertain significance Single submitter
- ABCC4 p.Ser46Leu Uncertain significance Single submitter
- ABCC4 p.Thr191Ala Uncertain significance Single submitter
- ABCC4 p.Thr434Ile Uncertain significance Single submitter
- ABCC4 p.Thr839Met Uncertain significance Single submitter
- ABCC4 p.Trp863Gly Uncertain significance Single submitter
- ABCC4 p.Tyr477Cys Uncertain significance Single submitter
- ABCC4 p.Tyr701Cys Uncertain significance Single submitter
- ABCC4 p.Val1179Ala Uncertain significance Single submitter
- ABCC4 p.Val1260Phe Uncertain significance Single submitter
- ABCC4 p.Val353Met Uncertain significance Single submitter
- ABCC4 p.Val381Ile Likely benign Single submitter
- ABCC4 p.Val471Met Uncertain significance Single submitter
- ABCC4 p.Val612Leu Uncertain significance Single submitter
- ABCC4 p.Val854Phe Likely benign Single submitter
- ABCC4 p.Val860Met Uncertain significance Single submitter
-
ABCC4 p.Val549Leu
Uncertain significance
No assertion criteria
prostate cancer
All ABCC4 variants
Benign 24
- c.1825-7A>G Multiple submitters
- c.185+7C>T Multiple submitters
- p.Ala700= Multiple submitters
- p.Ile866Val Multiple submitters
- p.Met744Val Multiple submitters
- c.1161+8T>A Single submitter
- c.186-5T>C Single submitter
- c.3871-3T>C Single submitter
- c.531+10A>G Single submitter
- c.74+10C>T Single submitter
- p.Ala1203= Single submitter
- p.Arg317= Single submitter
- p.Glu757Lys Single submitter ⚠
- p.Gly187Trp Single submitter ⚠
- p.Ile223= Single submitter
- p.Leu1104= Single submitter
- p.Leu18Ile Single submitter
- p.Leu904= Single submitter
- p.Lys1116= Single submitter
- p.Lys304Asn Single submitter ⚠
- p.Phe948= Single submitter
- p.Pro1258= Single submitter
- p.Ser323= Single submitter
- p.Tyr499= Single submitter
Benign/Likely benign 4
- c.307-10C>T Multiple submitters
- p.Ile1085= Multiple submitters
- p.Lys498Glu Multiple submitters
- p.Thr1142Met Multiple submitters ⚠
Likely benign 19
- p.Met184Thr Multiple submitters
- c.1162-3T>C Single submitter
- c.2917+10G>A Single submitter
- p.Asp1256= Single submitter
- p.Cys579= Single submitter
- p.Gln662= Single submitter
- p.Glu688Asp Single submitter ⚠
- p.Leu13= Single submitter
- p.Met1306Ile Single submitter
- p.Phe574= Single submitter
- p.Pro667= Single submitter
- p.Ser486= Single submitter
- p.Thr885= Single submitter
- p.Val345= Single submitter
- p.Val381Ile Single submitter ⚠
- p.Val854Phe Single submitter ⚠
- p.Val900Leu Single submitter
- c.3871-5dup No assertion criteria ABCC4-related disorder
- p.Pro403Leu No assertion criteria ABCC4-related disorder
Uncertain significance 136
- p.Ala1282Thr Multiple submitters ⚠
- p.Ala1324Thr Multiple submitters ⚠
- p.Leu238Phe Multiple submitters ⚠
- p.Tyr788Cys Multiple submitters ⚠
- c.2176-2A>G Single submitter
- p.Ala1149Gly Single submitter ⚠
- p.Ala134Gly Single submitter ⚠
- p.Ala224Val Single submitter ⚠
- p.Ala227Ser Single submitter ⚠
- p.Ala266Pro Single submitter ⚠
- p.Ala422Val Single submitter ⚠
- p.Ala567Val Single submitter ⚠
- p.Ala673Val Single submitter ⚠
- p.Ala709Thr Single submitter ⚠
- p.Ala75Thr Single submitter ⚠
- p.Ala859Val Single submitter ⚠
- p.Arg180Cys Single submitter ⚠
- p.Arg180His Single submitter ⚠
- p.Arg398His Single submitter ⚠
- p.Arg474Gly Single submitter ⚠
- p.Arg824His Single submitter ⚠
- p.Arg82Ser Single submitter ⚠
- p.Arg879Trp Single submitter ⚠
- p.Arg897Gln Single submitter ⚠
- p.Arg897Gly Single submitter ⚠
- p.Arg915Gln Single submitter ⚠
- p.Arg915Trp Single submitter ⚠
- p.Arg951Cys Single submitter ⚠
- p.Arg951His Single submitter ⚠
- p.Asn1134Ser Single submitter ⚠
- p.Asn1312Ser Single submitter ⚠
- p.Asn17Lys Single submitter ⚠
- p.Asn203His Single submitter ⚠
- p.Asn544Lys Single submitter ⚠
- p.Asn703Tyr Single submitter ⚠
- p.Asn816His Single submitter ⚠
- p.Asn823Ile Single submitter ⚠
- p.Asp516Tyr Single submitter ⚠
- p.Asp51Tyr Single submitter ⚠
- p.Asp932Gly Single submitter ⚠
- p.Cys579Gly Single submitter ⚠
- p.Gln109Arg Single submitter ⚠
- p.Gln397Arg Single submitter ⚠
- p.Gln481Leu Single submitter ⚠
- p.Gln518His Single submitter ⚠
- p.Gln595Pro Single submitter ⚠
- p.Gln999Pro Single submitter ⚠
- p.Glu1004Ala Single submitter ⚠
- p.Glu1095Lys Single submitter ⚠
- p.Glu1123Lys Single submitter ⚠
- p.Glu1145Gly Single submitter ⚠
- p.Glu1266Lys Single submitter ⚠
- p.Glu1280Lys Single submitter ⚠
- p.Glu568Lys Single submitter ⚠
- p.Glu639Lys Single submitter ⚠
- p.Gly1078Arg Single submitter ⚠
- p.Gly1129Ala Single submitter ⚠
- p.Gly445Ser Single submitter ⚠
- p.Gly467Arg Single submitter ⚠
- p.Gly487Glu Single submitter ⚠
- p.Gly615Glu Single submitter ⚠
- p.Gly62Arg Single submitter ⚠
- p.His1299Arg Single submitter ⚠
- p.His1305Tyr Single submitter ⚠
- p.His583Asn Single submitter ⚠
- p.His583Tyr Single submitter ⚠
- p.Ile1073Val Single submitter ⚠
- p.Ile1199Val Single submitter ⚠
- p.Ile1238Val Single submitter ⚠
- p.Ile1320Thr Single submitter ⚠
- p.Ile233Met Single submitter ⚠
- p.Ile280Thr Single submitter ⚠
- p.Ile578Val Single submitter ⚠
- p.Ile780Lys Single submitter ⚠
- p.Ile818Val Single submitter ⚠
- p.Leu1019Val Single submitter ⚠
- p.Leu1061Val Single submitter ⚠
- p.Leu1162Ile Single submitter ⚠
- p.Leu146Phe Single submitter ⚠
- p.Leu342Phe Single submitter ⚠
- p.Leu719Phe Single submitter ⚠
- p.Lys1265Glu Single submitter ⚠
- p.Lys1294Glu Single submitter ⚠
- p.Lys36Glu Single submitter ⚠
- p.Lys509Thr Single submitter ⚠
- p.Met1131Val Single submitter ⚠
- p.Met44Ile Single submitter ⚠
- p.Phe485Val Single submitter ⚠
- p.Phe620Leu Single submitter ⚠
- p.Phe63Leu Single submitter ⚠
- p.Phe714Leu Single submitter ⚠
- p.Phe716Tyr Single submitter ⚠
- p.Phe877Ser Single submitter ⚠
- p.Pro10Arg Single submitter ⚠
- p.Pro1121Leu Single submitter ⚠
- p.Pro12Leu Single submitter ⚠
- p.Pro1315Leu Single submitter ⚠
- p.Pro642Leu Single submitter ⚠
- p.Ser1241Gly Single submitter ⚠
- p.Ser1316Leu Single submitter ⚠
- p.Ser199Pro Single submitter ⚠
- p.Ser294Pro Single submitter ⚠
- p.Ser313Arg Single submitter ⚠
- p.Ser328Asn Single submitter ⚠
- p.Ser396Ala Single submitter ⚠
- p.Ser46Leu Single submitter ⚠
- p.Ser570Asn Single submitter ⚠
- p.Ser570Ile Single submitter ⚠
- p.Thr1077Ser Single submitter ⚠
- p.Thr1204Met Single submitter ⚠
- p.Thr191Ala Single submitter ⚠
- p.Thr281Ser Single submitter ⚠
- p.Thr434Ile Single submitter ⚠
- p.Thr839Met Single submitter ⚠
- p.Thr885Met Single submitter ⚠
- p.Thr895Ala Single submitter ⚠
- p.Trp863Gly Single submitter ⚠
- p.Tyr1259Asp Single submitter ⚠
- p.Tyr477Cys Single submitter ⚠
- p.Tyr701Cys Single submitter ⚠
- p.Tyr704Cys Single submitter ⚠
- p.Val1071Ile Single submitter ⚠
- p.Val1179Ala Single submitter ⚠
- p.Val1246Leu Single submitter ⚠
- p.Val1260Phe Single submitter ⚠
- p.Val140Met Single submitter ⚠
- p.Val279Ile Single submitter ⚠
- p.Val353Met Single submitter ⚠
- p.Val469Asp Single submitter ⚠
- p.Val471Met Single submitter ⚠
- p.Val612Leu Single submitter ⚠
- p.Val860Met Single submitter ⚠
- p.Val94Ala Single submitter ⚠
- p.Val963Ile Single submitter ⚠
- p.Arg891Leu No assertion criteria prostate cancer ⚠
- p.Val549Leu No assertion criteria prostate cancer ⚠