ABHD15 — 100 ClinVar variants
All ClinVar germline ABHD15 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 100 flagged for review →
1 Likely benign · 99 Uncertain significance
Full ABHD15 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 100
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 54
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ABHD15 p.Ala228Val Uncertain significance Single submitter
- ABHD15 p.Ala291Thr Uncertain significance Single submitter
- ABHD15 p.Ala444Ser Uncertain significance Single submitter
- ABHD15 p.Ala6Val Uncertain significance Single submitter
- ABHD15 p.Ala80Ser Uncertain significance Single submitter
- ABHD15 p.Arg193Pro Uncertain significance Single submitter
- ABHD15 p.Arg194Cys Uncertain significance Single submitter
- ABHD15 p.Arg312His Uncertain significance Single submitter
- ABHD15 p.Arg396His Uncertain significance Single submitter
- ABHD15 p.Arg420Gln Uncertain significance Single submitter
- ABHD15 p.Arg441Gly Uncertain significance Single submitter
- ABHD15 p.Arg44Leu Uncertain significance Single submitter
- ABHD15 p.Asn165Ser Uncertain significance Single submitter
- ABHD15 p.Asp138Ala Uncertain significance Single submitter
- ABHD15 p.Asp344Asn Uncertain significance Single submitter
- ABHD15 p.Asp344Gly Uncertain significance Single submitter
- ABHD15 p.Cys392Tyr Uncertain significance Single submitter
- ABHD15 p.Glu316Asp Uncertain significance Single submitter
- ABHD15 p.Glu398Gln Uncertain significance Single submitter
- ABHD15 p.Glu457Lys Uncertain significance Single submitter
- ABHD15 p.Glu458Asp Uncertain significance Single submitter
- ABHD15 p.Gly147Ser Uncertain significance Single submitter
- ABHD15 p.Gly154Ala Uncertain significance Single submitter
- ABHD15 p.Gly155Asp Uncertain significance Single submitter
- ABHD15 p.Gly437Arg Uncertain significance Single submitter
- ABHD15 p.Gly437Val Uncertain significance Single submitter
- ABHD15 p.Ile355Val Uncertain significance Single submitter
- ABHD15 p.Leu353Pro Uncertain significance Single submitter
- ABHD15 p.Phe412Ser Uncertain significance Single submitter
- ABHD15 p.Phe418Ser Uncertain significance Single submitter
- ABHD15 p.Pro212Leu Uncertain significance Single submitter
- ABHD15 p.Pro23Leu Uncertain significance Single submitter
- ABHD15 p.Pro341Leu Uncertain significance Single submitter
- ABHD15 p.Pro341Ser Uncertain significance Single submitter
- ABHD15 p.Pro366Leu Uncertain significance Single submitter
- ABHD15 p.Pro39Leu Uncertain significance Single submitter
- ABHD15 p.Pro97Arg Uncertain significance Single submitter
- ABHD15 p.Ser152Thr Uncertain significance Single submitter
- ABHD15 p.Ser240Leu Uncertain significance Single submitter
- ABHD15 p.Ser245Phe Uncertain significance Single submitter
- ABHD15 p.Ser306Gly Uncertain significance Single submitter
- ABHD15 p.Ser327Arg Uncertain significance Single submitter
- ABHD15 p.Ser429Asn Uncertain significance Single submitter
- ABHD15 p.Thr325Asn Uncertain significance Single submitter
- ABHD15 p.Trp29Arg Uncertain significance Single submitter
- ABHD15 p.Trp403Cys Uncertain significance Single submitter
- ABHD15 p.Trp4Arg Uncertain significance Single submitter
- ABHD15 p.Tyr126Cys Uncertain significance Single submitter
- ABHD15 p.Tyr187Cys Uncertain significance Single submitter
- ABHD15 p.Tyr255Cys Uncertain significance Single submitter
- ABHD15 p.Val189Phe Uncertain significance Single submitter
- ABHD15 p.Val33Ala Uncertain significance Single submitter
- ABHD15 p.Val362Met Uncertain significance Single submitter
- ABHD15 p.Val450Ala Uncertain significance Single submitter
Predictors split 46
The independent predictors disagree with each other — read with care.
- ABHD15 p.Ala16Pro Uncertain significance Single submitter
- ABHD15 p.Ala229Thr Uncertain significance Single submitter
- ABHD15 p.Ala233Thr Uncertain significance Single submitter
- ABHD15 p.Ala260Thr Uncertain significance Single submitter
- ABHD15 p.Ala358Pro Uncertain significance Single submitter
- ABHD15 p.Ala9Val Uncertain significance Single submitter
- ABHD15 p.Arg184Cys Uncertain significance Single submitter
- ABHD15 p.Arg31Cys Uncertain significance Single submitter
- ABHD15 p.Arg343Gln Uncertain significance Single submitter
- ABHD15 p.Arg343Trp Uncertain significance Single submitter
- ABHD15 p.Arg387Cys Uncertain significance Single submitter
- ABHD15 p.Arg396Cys Uncertain significance Single submitter
- ABHD15 p.Arg439Cys Uncertain significance Single submitter
- ABHD15 p.Arg439His Uncertain significance Single submitter
- ABHD15 p.Arg440His Uncertain significance Single submitter
- ABHD15 p.Arg441His Uncertain significance Single submitter
- ABHD15 p.Arg448Trp Uncertain significance Single submitter
- ABHD15 p.Arg464Gln Uncertain significance Single submitter
- ABHD15 p.Asn339Ser Uncertain significance Single submitter
- ABHD15 p.Asp333Asn Uncertain significance Single submitter
- ABHD15 p.Gln128His Uncertain significance Single submitter
- ABHD15 p.Glu347Gly Uncertain significance Single submitter
- ABHD15 p.Glu422Asp Uncertain significance Single submitter
- ABHD15 p.Glu49Lys Uncertain significance Single submitter
- ABHD15 p.Gly195Ser Uncertain significance Single submitter
- ABHD15 p.Gly198Arg Uncertain significance Single submitter
- ABHD15 p.Gly198Asp Uncertain significance Single submitter
- ABHD15 p.Gly364Val Uncertain significance Single submitter
- ABHD15 p.Gly40Val Uncertain significance Single submitter
- ABHD15 p.Gly47Val Uncertain significance Single submitter
- ABHD15 p.Ile355Met Uncertain significance Single submitter
- ABHD15 p.Leu15Pro Uncertain significance Single submitter
- ABHD15 p.Leu25Phe Uncertain significance Single submitter
- ABHD15 p.Lys75Gln Uncertain significance Single submitter
- ABHD15 p.Pro200Ser Uncertain significance Single submitter
- ABHD15 p.Pro204Leu Uncertain significance Single submitter
- ABHD15 p.Pro227Arg Uncertain significance Single submitter
- ABHD15 p.Pro227Ser Uncertain significance Single submitter
- ABHD15 p.Pro361Ala Uncertain significance Single submitter
- ABHD15 p.Pro366Ser Uncertain significance Single submitter
- ABHD15 p.Pro97Leu Uncertain significance Single submitter
- ABHD15 p.Ser213Tyr Uncertain significance Single submitter
- ABHD15 p.Thr37Asn Uncertain significance Single submitter
- ABHD15 p.Thr421Met Likely benign Single submitter
- ABHD15 p.Val162Met Uncertain significance Single submitter
- ABHD15 p.Val189Ile Uncertain significance Single submitter
All ABHD15 variants
Likely benign 1
- p.Thr421Met Single submitter ⚠
Uncertain significance 99
- p.Ala16Pro Single submitter ⚠
- p.Ala228Val Single submitter ⚠
- p.Ala229Thr Single submitter ⚠
- p.Ala233Thr Single submitter ⚠
- p.Ala260Thr Single submitter ⚠
- p.Ala291Thr Single submitter ⚠
- p.Ala358Pro Single submitter ⚠
- p.Ala444Ser Single submitter ⚠
- p.Ala6Val Single submitter ⚠
- p.Ala80Ser Single submitter ⚠
- p.Ala9Val Single submitter ⚠
- p.Arg184Cys Single submitter ⚠
- p.Arg193Pro Single submitter ⚠
- p.Arg194Cys Single submitter ⚠
- p.Arg312His Single submitter ⚠
- p.Arg31Cys Single submitter ⚠
- p.Arg343Gln Single submitter ⚠
- p.Arg343Trp Single submitter ⚠
- p.Arg387Cys Single submitter ⚠
- p.Arg396Cys Single submitter ⚠
- p.Arg396His Single submitter ⚠
- p.Arg420Gln Single submitter ⚠
- p.Arg439Cys Single submitter ⚠
- p.Arg439His Single submitter ⚠
- p.Arg440His Single submitter ⚠
- p.Arg441Gly Single submitter ⚠
- p.Arg441His Single submitter ⚠
- p.Arg448Trp Single submitter ⚠
- p.Arg44Leu Single submitter ⚠
- p.Arg464Gln Single submitter ⚠
- p.Asn165Ser Single submitter ⚠
- p.Asn339Ser Single submitter ⚠
- p.Asp138Ala Single submitter ⚠
- p.Asp333Asn Single submitter ⚠
- p.Asp344Asn Single submitter ⚠
- p.Asp344Gly Single submitter ⚠
- p.Cys392Tyr Single submitter ⚠
- p.Gln128His Single submitter ⚠
- p.Glu316Asp Single submitter ⚠
- p.Glu347Gly Single submitter ⚠
- p.Glu398Gln Single submitter ⚠
- p.Glu422Asp Single submitter ⚠
- p.Glu457Lys Single submitter ⚠
- p.Glu458Asp Single submitter ⚠
- p.Glu49Lys Single submitter ⚠
- p.Gly147Ser Single submitter ⚠
- p.Gly154Ala Single submitter ⚠
- p.Gly155Asp Single submitter ⚠
- p.Gly195Ser Single submitter ⚠
- p.Gly198Arg Single submitter ⚠
- p.Gly198Asp Single submitter ⚠
- p.Gly364Val Single submitter ⚠
- p.Gly40Val Single submitter ⚠
- p.Gly437Arg Single submitter ⚠
- p.Gly437Val Single submitter ⚠
- p.Gly47Val Single submitter ⚠
- p.Ile355Met Single submitter ⚠
- p.Ile355Val Single submitter ⚠
- p.Leu15Pro Single submitter ⚠
- p.Leu25Phe Single submitter ⚠
- p.Leu353Pro Single submitter ⚠
- p.Lys75Gln Single submitter ⚠
- p.Phe412Ser Single submitter ⚠
- p.Phe418Ser Single submitter ⚠
- p.Pro200Ser Single submitter ⚠
- p.Pro204Leu Single submitter ⚠
- p.Pro212Leu Single submitter ⚠
- p.Pro227Arg Single submitter ⚠
- p.Pro227Ser Single submitter ⚠
- p.Pro23Leu Single submitter ⚠
- p.Pro341Leu Single submitter ⚠
- p.Pro341Ser Single submitter ⚠
- p.Pro361Ala Single submitter ⚠
- p.Pro366Leu Single submitter ⚠
- p.Pro366Ser Single submitter ⚠
- p.Pro39Leu Single submitter ⚠
- p.Pro97Arg Single submitter ⚠
- p.Pro97Leu Single submitter ⚠
- p.Ser152Thr Single submitter ⚠
- p.Ser213Tyr Single submitter ⚠
- p.Ser240Leu Single submitter ⚠
- p.Ser245Phe Single submitter ⚠
- p.Ser306Gly Single submitter ⚠
- p.Ser327Arg Single submitter ⚠
- p.Ser429Asn Single submitter ⚠
- p.Thr325Asn Single submitter ⚠
- p.Thr37Asn Single submitter ⚠
- p.Trp29Arg Single submitter ⚠
- p.Trp403Cys Single submitter ⚠
- p.Trp4Arg Single submitter ⚠
- p.Tyr126Cys Single submitter ⚠
- p.Tyr187Cys Single submitter ⚠
- p.Tyr255Cys Single submitter ⚠
- p.Val162Met Single submitter ⚠
- p.Val189Ile Single submitter ⚠
- p.Val189Phe Single submitter ⚠
- p.Val33Ala Single submitter ⚠
- p.Val362Met Single submitter ⚠
- p.Val450Ala Single submitter ⚠