ABLIM1 — 114 ClinVar variants
All ClinVar germline ABLIM1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 113 flagged for review →
1 Likely benign · 113 Uncertain significance
Full ABLIM1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 113
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 82
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ABLIM1 p.Ala506Thr Uncertain significance Multiple submitters
- ABLIM1 p.Ala29Val Uncertain significance Single submitter
- ABLIM1 p.Ala51Thr Uncertain significance Single submitter
- ABLIM1 p.Ala55Gly Uncertain significance Single submitter
- ABLIM1 p.Ala83Val Uncertain significance Single submitter
- ABLIM1 p.Arg112Gln Uncertain significance Single submitter
- ABLIM1 p.Arg157Cys Uncertain significance Single submitter
- ABLIM1 p.Arg443Gln Uncertain significance Single submitter
- ABLIM1 p.Arg445Gln Uncertain significance Single submitter
- ABLIM1 p.Arg463Cys Uncertain significance Single submitter
- ABLIM1 p.Arg472His Uncertain significance Single submitter
- ABLIM1 p.Arg499Cys Uncertain significance Single submitter
- ABLIM1 p.Arg53Ser Uncertain significance Single submitter
- ABLIM1 p.Arg666Pro Uncertain significance Single submitter
- ABLIM1 p.Arg666Trp Uncertain significance Single submitter
- ABLIM1 p.Arg71Cys Uncertain significance Single submitter
- ABLIM1 p.Arg71Leu Uncertain significance Single submitter
- ABLIM1 p.Arg73Cys Uncertain significance Single submitter
- ABLIM1 p.Arg742Cys Uncertain significance Single submitter
- ABLIM1 p.Arg742His Uncertain significance Single submitter
- ABLIM1 p.Arg750Gln Uncertain significance Single submitter
- ABLIM1 p.Arg750Leu Uncertain significance Single submitter
- ABLIM1 p.Asn180Ser Uncertain significance Single submitter
- ABLIM1 p.Asn235Ser Uncertain significance Single submitter
- ABLIM1 p.Asn315Ser Uncertain significance Single submitter
- ABLIM1 p.Asn33Lys Uncertain significance Single submitter
- ABLIM1 p.Asp232Gly Uncertain significance Single submitter
- ABLIM1 p.Asp415Gly Uncertain significance Single submitter
- ABLIM1 p.Asp581Gly Uncertain significance Single submitter
- ABLIM1 p.Asp639Asn Uncertain significance Single submitter
- ABLIM1 p.Cys285Tyr Uncertain significance Single submitter
- ABLIM1 p.Cys75Arg Uncertain significance Single submitter
- ABLIM1 p.Gln316His Uncertain significance Single submitter
- ABLIM1 p.Glu163Asp Uncertain significance Single submitter
- ABLIM1 p.Glu25Ala Uncertain significance Single submitter
- ABLIM1 p.Glu25Lys Uncertain significance Single submitter
- ABLIM1 p.Glu560Lys Uncertain significance Single submitter
- ABLIM1 p.Glu590Gly Uncertain significance Single submitter
- ABLIM1 p.Gly142Arg Uncertain significance Single submitter
- ABLIM1 p.Gly155Arg Uncertain significance Single submitter
- ABLIM1 p.Gly160Ser Uncertain significance Single submitter
- ABLIM1 p.Gly162Glu Uncertain significance Single submitter
- ABLIM1 p.Gly167Ser Uncertain significance Single submitter
- ABLIM1 p.Gly194Arg Uncertain significance Single submitter
- ABLIM1 p.Gly361Ser Uncertain significance Single submitter
- ABLIM1 p.Gly694Val Uncertain significance Single submitter
- ABLIM1 p.Gly72Arg Uncertain significance Single submitter
- ABLIM1 p.His448Leu Uncertain significance Single submitter
- ABLIM1 p.His59Arg Uncertain significance Single submitter
- ABLIM1 p.His84Tyr Uncertain significance Single submitter
- ABLIM1 p.Ile372Val Uncertain significance Single submitter
- ABLIM1 p.Ile380Val Uncertain significance Single submitter
- ABLIM1 p.Ile564Phe Uncertain significance Single submitter
- ABLIM1 p.Leu132Val Uncertain significance Single submitter
- ABLIM1 p.Leu205Phe Uncertain significance Single submitter
- ABLIM1 p.Leu208Val Uncertain significance Single submitter
- ABLIM1 p.Leu346Pro Uncertain significance Single submitter
- ABLIM1 p.Leu492Val Uncertain significance Single submitter
- ABLIM1 p.Met153Val Uncertain significance Single submitter
- ABLIM1 p.Met213Thr Uncertain significance Single submitter
- ABLIM1 p.Phe137Leu Uncertain significance Single submitter
- ABLIM1 p.Pro271Leu Uncertain significance Single submitter
- ABLIM1 p.Pro306Ser Uncertain significance Single submitter
- ABLIM1 p.Pro360Arg Uncertain significance Single submitter
- ABLIM1 p.Pro572Ser Uncertain significance Single submitter
- ABLIM1 p.Pro85Ala Uncertain significance Single submitter
- ABLIM1 p.Ser224Asn Uncertain significance Single submitter
- ABLIM1 p.Ser32Leu Uncertain significance Single submitter
- ABLIM1 p.Ser367Leu Uncertain significance Single submitter
- ABLIM1 p.Ser541Ala Uncertain significance Single submitter
- ABLIM1 p.Ser632Pro Uncertain significance Single submitter
- ABLIM1 p.Ser77Gly Uncertain significance Single submitter
- ABLIM1 p.Thr342Ser Uncertain significance Single submitter
- ABLIM1 p.Thr470Met Uncertain significance Single submitter
- ABLIM1 p.Thr561Ser Uncertain significance Single submitter
- ABLIM1 p.Tyr373Ser Uncertain significance Single submitter
- ABLIM1 p.Tyr461Asp Uncertain significance Single submitter
- ABLIM1 p.Tyr675Cys Uncertain significance Single submitter
- ABLIM1 p.Val165Leu Uncertain significance Single submitter
- ABLIM1 p.Val331Ile Uncertain significance Single submitter
- ABLIM1 p.Val748Ala Uncertain significance Single submitter
- ABLIM1 p.Val82Ala Uncertain significance Single submitter
Predictors split 31
The independent predictors disagree with each other — read with care.
- ABLIM1 p.Arg152Gln Uncertain significance Single submitter
- ABLIM1 p.Arg189His Uncertain significance Single submitter
- ABLIM1 p.Arg428Lys Uncertain significance Single submitter
- ABLIM1 p.Arg449Gln Uncertain significance Single submitter
- ABLIM1 p.Arg463His Uncertain significance Single submitter
- ABLIM1 p.Arg495Trp Uncertain significance Single submitter
- ABLIM1 p.Arg628Gln Uncertain significance Single submitter
- ABLIM1 p.Arg628Trp Uncertain significance Single submitter
- ABLIM1 p.Arg666Gln Uncertain significance Single submitter
- ABLIM1 p.Arg733Gly Uncertain significance Single submitter
- ABLIM1 p.Asp301Asn Uncertain significance Single submitter
- ABLIM1 p.Asp543Gly Uncertain significance Single submitter
- ABLIM1 p.Asp592His Uncertain significance Single submitter
- ABLIM1 p.Glu591Lys Uncertain significance Single submitter
- ABLIM1 p.Glu751Lys Uncertain significance Single submitter
- ABLIM1 p.Gly361Ala Uncertain significance Single submitter
- ABLIM1 p.Gly487Ser Uncertain significance Single submitter
- ABLIM1 p.Ile757Val Uncertain significance Single submitter
- ABLIM1 p.Leu492Phe Uncertain significance Single submitter
- ABLIM1 p.Pro105Arg Uncertain significance Single submitter
- ABLIM1 p.Pro491Thr Uncertain significance Single submitter
- ABLIM1 p.Pro493Leu Uncertain significance Single submitter
- ABLIM1 p.Ser214Leu Uncertain significance Single submitter
- ABLIM1 p.Ser540Cys Uncertain significance Single submitter
- ABLIM1 p.Ser632Cys Uncertain significance Single submitter
- ABLIM1 p.Ser636Ile Uncertain significance Single submitter
- ABLIM1 p.Thr429Ser Uncertain significance Single submitter
- ABLIM1 p.Thr566Met Uncertain significance Single submitter
- ABLIM1 p.Thr724Ala Uncertain significance Single submitter
- ABLIM1 p.Tyr406His Uncertain significance Single submitter
- ABLIM1 p.Tyr678Cys Uncertain significance Single submitter
All ABLIM1 variants
Likely benign 1
- p.Val78Leu Single submitter
Uncertain significance 113
- p.Ala506Thr Multiple submitters ⚠
- p.Ala29Val Single submitter ⚠
- p.Ala51Thr Single submitter ⚠
- p.Ala55Gly Single submitter ⚠
- p.Ala83Val Single submitter ⚠
- p.Arg112Gln Single submitter ⚠
- p.Arg152Gln Single submitter ⚠
- p.Arg157Cys Single submitter ⚠
- p.Arg189His Single submitter ⚠
- p.Arg428Lys Single submitter ⚠
- p.Arg443Gln Single submitter ⚠
- p.Arg445Gln Single submitter ⚠
- p.Arg449Gln Single submitter ⚠
- p.Arg463Cys Single submitter ⚠
- p.Arg463His Single submitter ⚠
- p.Arg472His Single submitter ⚠
- p.Arg495Trp Single submitter ⚠
- p.Arg499Cys Single submitter ⚠
- p.Arg53Ser Single submitter ⚠
- p.Arg628Gln Single submitter ⚠
- p.Arg628Trp Single submitter ⚠
- p.Arg666Gln Single submitter ⚠
- p.Arg666Pro Single submitter ⚠
- p.Arg666Trp Single submitter ⚠
- p.Arg71Cys Single submitter ⚠
- p.Arg71Leu Single submitter ⚠
- p.Arg733Gly Single submitter ⚠
- p.Arg73Cys Single submitter ⚠
- p.Arg742Cys Single submitter ⚠
- p.Arg742His Single submitter ⚠
- p.Arg750Gln Single submitter ⚠
- p.Arg750Leu Single submitter ⚠
- p.Asn180Ser Single submitter ⚠
- p.Asn235Ser Single submitter ⚠
- p.Asn315Ser Single submitter ⚠
- p.Asn33Lys Single submitter ⚠
- p.Asp232Gly Single submitter ⚠
- p.Asp301Asn Single submitter ⚠
- p.Asp415Gly Single submitter ⚠
- p.Asp543Gly Single submitter ⚠
- p.Asp581Gly Single submitter ⚠
- p.Asp592His Single submitter ⚠
- p.Asp639Asn Single submitter ⚠
- p.Cys285Tyr Single submitter ⚠
- p.Cys75Arg Single submitter ⚠
- p.Gln316His Single submitter ⚠
- p.Glu163Asp Single submitter ⚠
- p.Glu25Ala Single submitter ⚠
- p.Glu25Lys Single submitter ⚠
- p.Glu560Lys Single submitter ⚠
- p.Glu590Gly Single submitter ⚠
- p.Glu591Lys Single submitter ⚠
- p.Glu751Lys Single submitter ⚠
- p.Gly142Arg Single submitter ⚠
- p.Gly155Arg Single submitter ⚠
- p.Gly160Ser Single submitter ⚠
- p.Gly162Glu Single submitter ⚠
- p.Gly167Ser Single submitter ⚠
- p.Gly194Arg Single submitter ⚠
- p.Gly361Ala Single submitter ⚠
- p.Gly361Ser Single submitter ⚠
- p.Gly487Ser Single submitter ⚠
- p.Gly694Val Single submitter ⚠
- p.Gly72Arg Single submitter ⚠
- p.His448Leu Single submitter ⚠
- p.His59Arg Single submitter ⚠
- p.His84Tyr Single submitter ⚠
- p.Ile372Val Single submitter ⚠
- p.Ile380Val Single submitter ⚠
- p.Ile564Phe Single submitter ⚠
- p.Ile757Val Single submitter ⚠
- p.Leu132Val Single submitter ⚠
- p.Leu205Phe Single submitter ⚠
- p.Leu208Val Single submitter ⚠
- p.Leu346Pro Single submitter ⚠
- p.Leu492Phe Single submitter ⚠
- p.Leu492Val Single submitter ⚠
- p.Met153Val Single submitter ⚠
- p.Met213Thr Single submitter ⚠
- p.Phe137Leu Single submitter ⚠
- p.Pro105Arg Single submitter ⚠
- p.Pro271Leu Single submitter ⚠
- p.Pro306Ser Single submitter ⚠
- p.Pro360Arg Single submitter ⚠
- p.Pro491Thr Single submitter ⚠
- p.Pro493Leu Single submitter ⚠
- p.Pro572Ser Single submitter ⚠
- p.Pro85Ala Single submitter ⚠
- p.Ser214Leu Single submitter ⚠
- p.Ser224Asn Single submitter ⚠
- p.Ser32Leu Single submitter ⚠
- p.Ser367Leu Single submitter ⚠
- p.Ser540Cys Single submitter ⚠
- p.Ser541Ala Single submitter ⚠
- p.Ser632Cys Single submitter ⚠
- p.Ser632Pro Single submitter ⚠
- p.Ser636Ile Single submitter ⚠
- p.Ser77Gly Single submitter ⚠
- p.Thr342Ser Single submitter ⚠
- p.Thr429Ser Single submitter ⚠
- p.Thr470Met Single submitter ⚠
- p.Thr561Ser Single submitter ⚠
- p.Thr566Met Single submitter ⚠
- p.Thr724Ala Single submitter ⚠
- p.Tyr373Ser Single submitter ⚠
- p.Tyr406His Single submitter ⚠
- p.Tyr461Asp Single submitter ⚠
- p.Tyr675Cys Single submitter ⚠
- p.Tyr678Cys Single submitter ⚠
- p.Val165Leu Single submitter ⚠
- p.Val331Ile Single submitter ⚠
- p.Val748Ala Single submitter ⚠
- p.Val82Ala Single submitter ⚠