ACAP3 — 140 ClinVar variants
All ClinVar germline ACAP3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 136 flagged for review →
4 Likely benign · 136 Uncertain significance
Full ACAP3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 136
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 49
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ACAP3 p.Ala242Val Uncertain significance Single submitter
- ACAP3 p.Ala282Thr Uncertain significance Single submitter
- ACAP3 p.Ala392Thr Uncertain significance Single submitter
- ACAP3 p.Ala526Thr Uncertain significance Single submitter
- ACAP3 p.Ala596Val Uncertain significance Single submitter
- ACAP3 p.Ala624Thr Uncertain significance Single submitter
- ACAP3 p.Ala649Thr Uncertain significance Single submitter
- ACAP3 p.Arg238Gln Uncertain significance Single submitter
- ACAP3 p.Arg246Gln Uncertain significance Single submitter
- ACAP3 p.Arg456Gln Uncertain significance Single submitter
- ACAP3 p.Arg456Trp Uncertain significance Single submitter
- ACAP3 p.Arg501Trp Uncertain significance Single submitter
- ACAP3 p.Arg540Gln Uncertain significance Single submitter
- ACAP3 p.Arg552Leu Uncertain significance Single submitter
- ACAP3 p.Arg555Gly Uncertain significance Single submitter
- ACAP3 p.Arg80Lys Uncertain significance Single submitter
- ACAP3 p.Asp188Asn Uncertain significance Single submitter
- ACAP3 p.Asp228Asn Uncertain significance Single submitter
- ACAP3 p.Glu333Lys Uncertain significance Single submitter
- ACAP3 p.Glu348Gln Uncertain significance Single submitter
- ACAP3 p.Glu528Asp Uncertain significance Single submitter
- ACAP3 p.Glu816Gln Uncertain significance Single submitter
- ACAP3 p.Gly489Ala Uncertain significance Single submitter
- ACAP3 p.Gly597Arg Uncertain significance Single submitter
- ACAP3 p.Gly626Ser Uncertain significance Single submitter
- ACAP3 p.Gly647Asp Uncertain significance Single submitter
- ACAP3 p.Gly659Ser Uncertain significance Single submitter
- ACAP3 p.Gly669Glu Uncertain significance Single submitter
- ACAP3 p.Gly759Ser Uncertain significance Single submitter
- ACAP3 p.His451Tyr Uncertain significance Single submitter
- ACAP3 p.His673Gln Uncertain significance Single submitter
- ACAP3 p.Ile389Met Uncertain significance Single submitter
- ACAP3 p.Leu207Val Uncertain significance Single submitter
- ACAP3 p.Leu378Val Uncertain significance Single submitter
- ACAP3 p.Lys537Gln Uncertain significance Single submitter
- ACAP3 p.Phe184Tyr Uncertain significance Single submitter
- ACAP3 p.Pro548Ser Uncertain significance Single submitter
- ACAP3 p.Pro804Leu Uncertain significance Single submitter
- ACAP3 p.Pro806Ser Uncertain significance Single submitter
- ACAP3 p.Pro806Thr Uncertain significance Single submitter
- ACAP3 p.Ser292Phe Uncertain significance Single submitter
- ACAP3 p.Ser416Asn Uncertain significance Single submitter
- ACAP3 p.Ser642Leu Uncertain significance Single submitter
- ACAP3 p.Ser642Pro Uncertain significance Single submitter
- ACAP3 p.Thr459Met Uncertain significance Single submitter
- ACAP3 p.Val27Leu Uncertain significance Single submitter
- ACAP3 p.Val409Leu Uncertain significance Single submitter
- ACAP3 p.Val61Ile Uncertain significance Single submitter
- ACAP3 p.Val663Ala Uncertain significance Single submitter
Predictors split 87
The independent predictors disagree with each other — read with care.
- ACAP3 p.Ala265Val Uncertain significance Single submitter
- ACAP3 p.Ala307Thr Uncertain significance Single submitter
- ACAP3 p.Ala598Thr Uncertain significance Single submitter
- ACAP3 p.Ala657Thr Uncertain significance Single submitter
- ACAP3 p.Ala657Val Uncertain significance Single submitter
- ACAP3 p.Ala683Val Uncertain significance Single submitter
- ACAP3 p.Ala685Val Uncertain significance Single submitter
- ACAP3 p.Ala764Ser Uncertain significance Single submitter
- ACAP3 p.Ala794Val Uncertain significance Single submitter
- ACAP3 p.Ala803Val Uncertain significance Single submitter
- ACAP3 p.Arg144Lys Uncertain significance Single submitter
- ACAP3 p.Arg14Cys Uncertain significance Single submitter
- ACAP3 p.Arg246Trp Uncertain significance Single submitter
- ACAP3 p.Arg367Cys Uncertain significance Single submitter
- ACAP3 p.Arg380Cys Uncertain significance Single submitter
- ACAP3 p.Arg380Pro Uncertain significance Single submitter
- ACAP3 p.Arg396Trp Uncertain significance Single submitter
- ACAP3 p.Arg398His Uncertain significance Single submitter
- ACAP3 p.Arg427Cys Uncertain significance Single submitter
- ACAP3 p.Arg427Gly Uncertain significance Single submitter
- ACAP3 p.Arg427His Uncertain significance Single submitter
- ACAP3 p.Arg519Trp Uncertain significance Single submitter
- ACAP3 p.Arg546Cys Uncertain significance Single submitter
- ACAP3 p.Arg551Cys Uncertain significance Single submitter
- ACAP3 p.Arg552His Uncertain significance Single submitter
- ACAP3 p.Arg555Trp Uncertain significance Single submitter
- ACAP3 p.Arg664Cys Uncertain significance Single submitter
- ACAP3 p.Arg735Gln Uncertain significance Single submitter
- ACAP3 p.Arg748Cys Uncertain significance Single submitter
- ACAP3 p.Arg798Leu Uncertain significance Single submitter
- ACAP3 p.Asn176Ser Uncertain significance Single submitter
- ACAP3 p.Asn287His Uncertain significance Single submitter
- ACAP3 p.Asn287Ser Uncertain significance Single submitter
- ACAP3 p.Asn781Asp Uncertain significance Single submitter
- ACAP3 p.Asn781His Uncertain significance Single submitter
- ACAP3 p.Asp425His Uncertain significance Single submitter
- ACAP3 p.Asp609Asn Uncertain significance Single submitter
- ACAP3 p.Asp63Asn Uncertain significance Single submitter
- ACAP3 p.Asp71Glu Uncertain significance Single submitter
- ACAP3 p.Asp728Asn Uncertain significance Single submitter
- ACAP3 p.Cys40Tyr Uncertain significance Single submitter
- ACAP3 p.Gln108Arg Uncertain significance Single submitter
- ACAP3 p.Gln301Arg Uncertain significance Single submitter
- ACAP3 p.Gln502Lys Uncertain significance Single submitter
- ACAP3 p.Gln769His Uncertain significance Single submitter
- ACAP3 p.Glu113Lys Uncertain significance Single submitter
- ACAP3 p.Glu21Lys Uncertain significance Single submitter
- ACAP3 p.Glu272Gln Uncertain significance Single submitter
- ACAP3 p.Glu644Lys Uncertain significance Single submitter
- ACAP3 p.Glu693Lys Uncertain significance Single submitter
- ACAP3 p.Glu76Lys Uncertain significance Single submitter
- ACAP3 p.Glu816Lys Uncertain significance Single submitter
- ACAP3 p.Gly155Arg Uncertain significance Single submitter
- ACAP3 p.Gly422Cys Uncertain significance Single submitter
- ACAP3 p.Gly422Ser Uncertain significance Single submitter
- ACAP3 p.His451Gln Uncertain significance Single submitter
- ACAP3 p.Ile326Val Uncertain significance Single submitter
- ACAP3 p.Ile362Val Uncertain significance Single submitter
- ACAP3 p.Ile94Phe Uncertain significance Single submitter
- ACAP3 p.Leu225Arg Uncertain significance Single submitter
- ACAP3 p.Met215Arg Uncertain significance Single submitter
- ACAP3 p.Met342Ile Uncertain significance Single submitter
- ACAP3 p.Met342Val Uncertain significance Single submitter
- ACAP3 p.Met43Val Uncertain significance Single submitter
- ACAP3 p.Phe15Val Uncertain significance Single submitter
- ACAP3 p.Phe819Leu Uncertain significance Single submitter
- ACAP3 p.Pro424Arg Uncertain significance Single submitter
- ACAP3 p.Pro424Leu Uncertain significance Single submitter
- ACAP3 p.Pro603Thr Uncertain significance Single submitter
- ACAP3 p.Ser253Cys Uncertain significance Single submitter
- ACAP3 p.Ser292Ala Uncertain significance Single submitter
- ACAP3 p.Ser369Arg Uncertain significance Single submitter
- ACAP3 p.Ser372Asn Uncertain significance Single submitter
- ACAP3 p.Ser462Leu Uncertain significance Single submitter
- ACAP3 p.Ser544Phe Uncertain significance Single submitter
- ACAP3 p.Ser589Leu Uncertain significance Single submitter
- ACAP3 p.Ser645Phe Uncertain significance Single submitter
- ACAP3 p.Thr24Met Uncertain significance Single submitter
- ACAP3 p.Thr2Ile Uncertain significance Single submitter
- ACAP3 p.Thr386Met Uncertain significance Single submitter
- ACAP3 p.Val269Leu Uncertain significance Single submitter
- ACAP3 p.Val26Met Uncertain significance Single submitter
- ACAP3 p.Val400Met Uncertain significance Single submitter
- ACAP3 p.Val559Ile Uncertain significance Single submitter
- ACAP3 p.Val73Ile Uncertain significance Single submitter
- ACAP3 p.Val73Leu Uncertain significance Single submitter
- ACAP3 p.Val777Leu Uncertain significance Single submitter
All ACAP3 variants
Likely benign 4
- p.Gly419= Single submitter
- p.Leu539Pro Single submitter
- p.Leu787= Single submitter
- p.Thr395Ser Single submitter
Uncertain significance 136
- p.Ala242Val Single submitter ⚠
- p.Ala265Val Single submitter ⚠
- p.Ala282Thr Single submitter ⚠
- p.Ala307Thr Single submitter ⚠
- p.Ala392Thr Single submitter ⚠
- p.Ala526Thr Single submitter ⚠
- p.Ala596Val Single submitter ⚠
- p.Ala598Thr Single submitter ⚠
- p.Ala624Thr Single submitter ⚠
- p.Ala649Thr Single submitter ⚠
- p.Ala657Thr Single submitter ⚠
- p.Ala657Val Single submitter ⚠
- p.Ala683Val Single submitter ⚠
- p.Ala685Val Single submitter ⚠
- p.Ala764Ser Single submitter ⚠
- p.Ala794Val Single submitter ⚠
- p.Ala803Val Single submitter ⚠
- p.Arg144Lys Single submitter ⚠
- p.Arg14Cys Single submitter ⚠
- p.Arg238Gln Single submitter ⚠
- p.Arg246Gln Single submitter ⚠
- p.Arg246Trp Single submitter ⚠
- p.Arg367Cys Single submitter ⚠
- p.Arg380Cys Single submitter ⚠
- p.Arg380Pro Single submitter ⚠
- p.Arg396Trp Single submitter ⚠
- p.Arg398His Single submitter ⚠
- p.Arg427Cys Single submitter ⚠
- p.Arg427Gly Single submitter ⚠
- p.Arg427His Single submitter ⚠
- p.Arg456Gln Single submitter ⚠
- p.Arg456Trp Single submitter ⚠
- p.Arg501Trp Single submitter ⚠
- p.Arg519Trp Single submitter ⚠
- p.Arg540Gln Single submitter ⚠
- p.Arg546Cys Single submitter ⚠
- p.Arg551Cys Single submitter ⚠
- p.Arg552His Single submitter ⚠
- p.Arg552Leu Single submitter ⚠
- p.Arg555Gly Single submitter ⚠
- p.Arg555Trp Single submitter ⚠
- p.Arg664Cys Single submitter ⚠
- p.Arg735Gln Single submitter ⚠
- p.Arg748Cys Single submitter ⚠
- p.Arg798Leu Single submitter ⚠
- p.Arg80Lys Single submitter ⚠
- p.Asn176Ser Single submitter ⚠
- p.Asn287His Single submitter ⚠
- p.Asn287Ser Single submitter ⚠
- p.Asn781Asp Single submitter ⚠
- p.Asn781His Single submitter ⚠
- p.Asp188Asn Single submitter ⚠
- p.Asp228Asn Single submitter ⚠
- p.Asp425His Single submitter ⚠
- p.Asp609Asn Single submitter ⚠
- p.Asp63Asn Single submitter ⚠
- p.Asp71Glu Single submitter ⚠
- p.Asp728Asn Single submitter ⚠
- p.Cys40Tyr Single submitter ⚠
- p.Gln108Arg Single submitter ⚠
- p.Gln301Arg Single submitter ⚠
- p.Gln502Lys Single submitter ⚠
- p.Gln769His Single submitter ⚠
- p.Glu113Lys Single submitter ⚠
- p.Glu21Lys Single submitter ⚠
- p.Glu272Gln Single submitter ⚠
- p.Glu333Lys Single submitter ⚠
- p.Glu348Gln Single submitter ⚠
- p.Glu528Asp Single submitter ⚠
- p.Glu644Lys Single submitter ⚠
- p.Glu693Lys Single submitter ⚠
- p.Glu76Lys Single submitter ⚠
- p.Glu816Gln Single submitter ⚠
- p.Glu816Lys Single submitter ⚠
- p.Gly155Arg Single submitter ⚠
- p.Gly422Cys Single submitter ⚠
- p.Gly422Ser Single submitter ⚠
- p.Gly489Ala Single submitter ⚠
- p.Gly597Arg Single submitter ⚠
- p.Gly626Ser Single submitter ⚠
- p.Gly647Asp Single submitter ⚠
- p.Gly659Ser Single submitter ⚠
- p.Gly669Glu Single submitter ⚠
- p.Gly759Ser Single submitter ⚠
- p.His451Gln Single submitter ⚠
- p.His451Tyr Single submitter ⚠
- p.His673Gln Single submitter ⚠
- p.Ile326Val Single submitter ⚠
- p.Ile362Val Single submitter ⚠
- p.Ile389Met Single submitter ⚠
- p.Ile94Phe Single submitter ⚠
- p.Leu207Val Single submitter ⚠
- p.Leu225Arg Single submitter ⚠
- p.Leu378Val Single submitter ⚠
- p.Lys537Gln Single submitter ⚠
- p.Met215Arg Single submitter ⚠
- p.Met342Ile Single submitter ⚠
- p.Met342Val Single submitter ⚠
- p.Met43Val Single submitter ⚠
- p.Phe15Val Single submitter ⚠
- p.Phe184Tyr Single submitter ⚠
- p.Phe819Leu Single submitter ⚠
- p.Pro424Arg Single submitter ⚠
- p.Pro424Leu Single submitter ⚠
- p.Pro548Ser Single submitter ⚠
- p.Pro603Thr Single submitter ⚠
- p.Pro804Leu Single submitter ⚠
- p.Pro806Ser Single submitter ⚠
- p.Pro806Thr Single submitter ⚠
- p.Ser253Cys Single submitter ⚠
- p.Ser292Ala Single submitter ⚠
- p.Ser292Phe Single submitter ⚠
- p.Ser369Arg Single submitter ⚠
- p.Ser372Asn Single submitter ⚠
- p.Ser416Asn Single submitter ⚠
- p.Ser462Leu Single submitter ⚠
- p.Ser544Phe Single submitter ⚠
- p.Ser589Leu Single submitter ⚠
- p.Ser642Leu Single submitter ⚠
- p.Ser642Pro Single submitter ⚠
- p.Ser645Phe Single submitter ⚠
- p.Thr24Met Single submitter ⚠
- p.Thr2Ile Single submitter ⚠
- p.Thr386Met Single submitter ⚠
- p.Thr459Met Single submitter ⚠
- p.Val269Leu Single submitter ⚠
- p.Val26Met Single submitter ⚠
- p.Val27Leu Single submitter ⚠
- p.Val400Met Single submitter ⚠
- p.Val409Leu Single submitter ⚠
- p.Val559Ile Single submitter ⚠
- p.Val61Ile Single submitter ⚠
- p.Val663Ala Single submitter ⚠
- p.Val73Ile Single submitter ⚠
- p.Val73Leu Single submitter ⚠
- p.Val777Leu Single submitter ⚠