ACCS — 86 ClinVar variants
All ClinVar germline ACCS variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 79 flagged for review →
4 Benign · 4 Likely benign · 78 Uncertain significance
Full ACCS gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 79
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 42
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ACCS p.Ala11Val Uncertain significance Single submitter
- ACCS p.Ala77Ser Uncertain significance Single submitter
- ACCS p.Arg124Lys Uncertain significance Single submitter
- ACCS p.Arg351His Uncertain significance Single submitter
- ACCS p.Arg368Gln Uncertain significance Single submitter
- ACCS p.Arg406Cys Uncertain significance Single submitter
- ACCS p.Arg489His Uncertain significance Single submitter
- ACCS p.Arg48Cys Uncertain significance Single submitter
- ACCS p.Arg48His Uncertain significance Single submitter
- ACCS p.Asn374Asp Uncertain significance Single submitter
- ACCS p.Asn374Ser Uncertain significance Single submitter
- ACCS p.Asp121Asn Uncertain significance Single submitter
- ACCS p.Asp23Asn Uncertain significance Single submitter
- ACCS p.Asp87Val Uncertain significance Single submitter
- ACCS p.Cys15Ser Uncertain significance Single submitter
- ACCS p.Cys20Arg Uncertain significance Single submitter
- ACCS p.Glu287Lys Uncertain significance Single submitter
- ACCS p.Glu395Lys Uncertain significance Single submitter
- ACCS p.Glu78Lys Uncertain significance Single submitter
- ACCS p.Glu88Lys Uncertain significance Single submitter
- ACCS p.Gly17Asp Uncertain significance Single submitter
- ACCS p.Gly326Arg Uncertain significance Single submitter
- ACCS p.Gly333Arg Uncertain significance Single submitter
- ACCS p.His242Gln Uncertain significance Single submitter
- ACCS p.His382Arg Uncertain significance Single submitter
- ACCS p.His85Asp Uncertain significance Single submitter
- ACCS p.Ile284Val Uncertain significance Single submitter
- ACCS p.Leu330Phe Uncertain significance Single submitter
- ACCS p.Leu385Phe Uncertain significance Single submitter
- ACCS p.Met318Ile Uncertain significance Single submitter
- ACCS p.Met429Arg Uncertain significance Single submitter
- ACCS p.Phe148Leu Uncertain significance Single submitter
- ACCS p.Phe410Ser Uncertain significance Single submitter
- ACCS p.Ser443Phe Uncertain significance Single submitter
- ACCS p.Ser61Cys Uncertain significance Single submitter
- ACCS p.Thr14Ile Uncertain significance Single submitter
- ACCS p.Thr199Ala Uncertain significance Single submitter
- ACCS p.Val303Ile Uncertain significance Single submitter
- ACCS p.Val317Glu Uncertain significance Single submitter
- ACCS p.Val317Gly Uncertain significance Single submitter
- ACCS p.Val459Phe Uncertain significance Single submitter
- ACCS p.Val464Ile Uncertain significance Single submitter
Predictors split 37
The independent predictors disagree with each other — read with care.
- ACCS p.Ala237Thr Uncertain significance Single submitter
- ACCS p.Arg142Gln Uncertain significance Single submitter
- ACCS p.Arg142Trp Uncertain significance Single submitter
- ACCS p.Arg209Trp Uncertain significance Single submitter
- ACCS p.Arg331Cys Uncertain significance Single submitter
- ACCS p.Arg368Leu Uncertain significance Single submitter
- ACCS p.Arg368Trp Uncertain significance Single submitter
- ACCS p.Arg384Gln Uncertain significance Single submitter
- ACCS p.Arg384Trp Uncertain significance Single submitter
- ACCS p.Arg433His Uncertain significance Single submitter
- ACCS p.Arg434Cys Uncertain significance Single submitter
- ACCS p.Arg434His Uncertain significance Single submitter
- ACCS p.Arg473Lys Uncertain significance Single submitter
- ACCS p.Arg500Cys Likely benign Single submitter
- ACCS p.Asp121Tyr Uncertain significance Single submitter
- ACCS p.Asp134Asn Uncertain significance Single submitter
- ACCS p.Asp90Glu Uncertain significance Single submitter
- ACCS p.Glu162Gly Uncertain significance Single submitter
- ACCS p.Glu162Val Uncertain significance Single submitter
- ACCS p.Glu295Gln Uncertain significance Single submitter
- ACCS p.Gly221Trp Uncertain significance Single submitter
- ACCS p.Gly407Glu Uncertain significance Single submitter
- ACCS p.Gly409Ser Uncertain significance Single submitter
- ACCS p.Gly80Ser Uncertain significance Single submitter
- ACCS p.Leu149Val Uncertain significance Single submitter
- ACCS p.Pro156Leu Uncertain significance Single submitter
- ACCS p.Pro379Leu Uncertain significance Single submitter
- ACCS p.Ser255Gly Uncertain significance Single submitter
- ACCS p.Ser37Phe Uncertain significance Single submitter
- ACCS p.Thr103Ala Uncertain significance Single submitter
- ACCS p.Thr179Arg Uncertain significance Single submitter
- ACCS p.Thr334Met Uncertain significance Single submitter
- ACCS p.Tyr152Cys Uncertain significance Single submitter
- ACCS p.Tyr205Cys Uncertain significance Single submitter
- ACCS p.Tyr289Phe Uncertain significance Single submitter
- ACCS p.Tyr391Cys Uncertain significance Single submitter
- ACCS p.Val376Leu Uncertain significance Single submitter
All ACCS variants
Benign 4
- p.Arg489Cys Multiple submitters
- p.Val202= Multiple submitters
- p.Ala345= Single submitter
- p.Gly221Glu Single submitter
Likely benign 4
- p.Arg500Cys Single submitter ⚠
- p.Arg500His Single submitter
- p.Cys203Tyr Single submitter
- p.Phe325= Single submitter
Uncertain significance 78
- p.Ala11Val Single submitter ⚠
- p.Ala237Thr Single submitter ⚠
- p.Ala77Ser Single submitter ⚠
- p.Arg124Lys Single submitter ⚠
- p.Arg142Gln Single submitter ⚠
- p.Arg142Trp Single submitter ⚠
- p.Arg209Trp Single submitter ⚠
- p.Arg331Cys Single submitter ⚠
- p.Arg351His Single submitter ⚠
- p.Arg368Gln Single submitter ⚠
- p.Arg368Leu Single submitter ⚠
- p.Arg368Trp Single submitter ⚠
- p.Arg384Gln Single submitter ⚠
- p.Arg384Trp Single submitter ⚠
- p.Arg406Cys Single submitter ⚠
- p.Arg433His Single submitter ⚠
- p.Arg434Cys Single submitter ⚠
- p.Arg434His Single submitter ⚠
- p.Arg473Lys Single submitter ⚠
- p.Arg489His Single submitter ⚠
- p.Arg48Cys Single submitter ⚠
- p.Arg48His Single submitter ⚠
- p.Asn374Asp Single submitter ⚠
- p.Asn374Ser Single submitter ⚠
- p.Asp121Asn Single submitter ⚠
- p.Asp121Tyr Single submitter ⚠
- p.Asp134Asn Single submitter ⚠
- p.Asp23Asn Single submitter ⚠
- p.Asp87Val Single submitter ⚠
- p.Asp90Glu Single submitter ⚠
- p.Cys15Ser Single submitter ⚠
- p.Cys20Arg Single submitter ⚠
- p.Glu162Gly Single submitter ⚠
- p.Glu162Val Single submitter ⚠
- p.Glu287Lys Single submitter ⚠
- p.Glu295Gln Single submitter ⚠
- p.Glu395Lys Single submitter ⚠
- p.Glu78Lys Single submitter ⚠
- p.Glu88Lys Single submitter ⚠
- p.Gly17Asp Single submitter ⚠
- p.Gly221Trp Single submitter ⚠
- p.Gly326Arg Single submitter ⚠
- p.Gly333Arg Single submitter ⚠
- p.Gly407Glu Single submitter ⚠
- p.Gly409Ser Single submitter ⚠
- p.Gly80Ser Single submitter ⚠
- p.His242Gln Single submitter ⚠
- p.His382Arg Single submitter ⚠
- p.His85Asp Single submitter ⚠
- p.Ile284Val Single submitter ⚠
- p.Leu149Val Single submitter ⚠
- p.Leu330Phe Single submitter ⚠
- p.Leu385Phe Single submitter ⚠
- p.Met318Ile Single submitter ⚠
- p.Met429Arg Single submitter ⚠
- p.Phe148Leu Single submitter ⚠
- p.Phe410Ser Single submitter ⚠
- p.Pro156Leu Single submitter ⚠
- p.Pro379Leu Single submitter ⚠
- p.Ser255Gly Single submitter ⚠
- p.Ser37Phe Single submitter ⚠
- p.Ser443Phe Single submitter ⚠
- p.Ser61Cys Single submitter ⚠
- p.Thr103Ala Single submitter ⚠
- p.Thr14Ile Single submitter ⚠
- p.Thr179Arg Single submitter ⚠
- p.Thr199Ala Single submitter ⚠
- p.Thr334Met Single submitter ⚠
- p.Tyr152Cys Single submitter ⚠
- p.Tyr205Cys Single submitter ⚠
- p.Tyr289Phe Single submitter ⚠
- p.Tyr391Cys Single submitter ⚠
- p.Val303Ile Single submitter ⚠
- p.Val317Glu Single submitter ⚠
- p.Val317Gly Single submitter ⚠
- p.Val376Leu Single submitter ⚠
- p.Val459Phe Single submitter ⚠
- p.Val464Ile Single submitter ⚠