ACP2 — 70 ClinVar variants
All ClinVar germline ACP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 60 flagged for review →
5 Benign · 1 Benign/Likely benign · 5 Likely benign · 59 Uncertain significance
Full ACP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 60
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 32
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ACP2 p.Arg109Trp Uncertain significance Single submitter
- ACP2 p.Arg129His Uncertain significance Single submitter
- ACP2 p.Arg241His Uncertain significance Single submitter
- ACP2 p.Asp421Gly Uncertain significance Single submitter
- ACP2 p.Asp54Asn Uncertain significance Single submitter
- ACP2 p.Cys159Arg Uncertain significance Single submitter
- ACP2 p.Cys388Phe Uncertain significance Single submitter
- ACP2 p.Cys388Ser Uncertain significance Single submitter
- ACP2 p.Gln227Glu Uncertain significance Single submitter
- ACP2 p.Gln248Arg Uncertain significance Single submitter
- ACP2 p.Gln249Lys Uncertain significance Single submitter
- ACP2 p.Gln407His Uncertain significance Single submitter
- ACP2 p.Gln407Lys Uncertain significance Single submitter
- ACP2 p.Gln98His Uncertain significance Single submitter
- ACP2 p.Glu192Lys Uncertain significance Single submitter
- ACP2 p.Glu359Lys Uncertain significance Single submitter
- ACP2 p.Glu71Ala Uncertain significance Single submitter
- ACP2 p.Gly245Arg Uncertain significance Single submitter
- ACP2 p.Gly257Glu Uncertain significance Single submitter
- ACP2 p.Gly419Arg Uncertain significance Single submitter
- ACP2 p.Gly89Ser Uncertain significance Single submitter
- ACP2 p.His216Gln Uncertain significance Single submitter
- ACP2 p.Ile246Ser Uncertain significance Single submitter
- ACP2 p.Leu111Phe Uncertain significance Single submitter
- ACP2 p.Phe122Leu Uncertain significance Single submitter
- ACP2 p.Pro155Leu Uncertain significance Single submitter
- ACP2 p.Pro339Leu Uncertain significance Single submitter
- ACP2 p.Thr379Ile Uncertain significance Single submitter
- ACP2 p.Thr37Ser Uncertain significance Single submitter
- ACP2 p.Val381Ala Uncertain significance Single submitter
- ACP2 p.Val402Ile Uncertain significance Single submitter
- ACP2 p.Gly89Asp Uncertain significance No assertion criteria
Predictors split 28
The independent predictors disagree with each other — read with care.
- ACP2 p.Ala11Glu Uncertain significance Single submitter
- ACP2 p.Ala272Val Uncertain significance Single submitter
- ACP2 p.Ala336Thr Uncertain significance Single submitter
- ACP2 p.Ala336Val Uncertain significance Single submitter
- ACP2 p.Arg219His Likely benign Single submitter
- ACP2 p.Arg254Gln Uncertain significance Single submitter
- ACP2 p.Arg356Cys Uncertain significance Single submitter
- ACP2 p.Arg356His Likely benign Single submitter
- ACP2 p.Arg5Trp Uncertain significance Single submitter
- ACP2 p.Asp298His Uncertain significance Single submitter
- ACP2 p.Gln368His Uncertain significance Single submitter
- ACP2 p.Gln98Pro Uncertain significance Single submitter
- ACP2 p.Glu168Lys Uncertain significance Single submitter
- ACP2 p.Glu174Asp Uncertain significance Single submitter
- ACP2 p.Glu178Lys Uncertain significance Single submitter
- ACP2 p.Glu332Lys Uncertain significance Single submitter
- ACP2 p.Gly302Ala Uncertain significance Single submitter
- ACP2 p.Ile312Val Uncertain significance Single submitter
- ACP2 p.Leu372Arg Uncertain significance Single submitter
- ACP2 p.Pro132Ala Uncertain significance Single submitter
- ACP2 p.Pro173Ser Uncertain significance Single submitter
- ACP2 p.Pro226Ser Uncertain significance Single submitter
- ACP2 p.Pro410Leu Uncertain significance Single submitter
- ACP2 p.Thr269Ile Uncertain significance Single submitter
- ACP2 p.Thr358Ile Uncertain significance Single submitter
- ACP2 p.Tyr207Cys Uncertain significance Single submitter
- ACP2 p.Val100Phe Uncertain significance Single submitter
- ACP2 p.Val361Ile Uncertain significance Single submitter
All ACP2 variants
Benign 5
- c.856-4G>A Multiple submitters
- p.Val416= Multiple submitters
- c.1138+4A>G Single submitter
- p.Leu165= Single submitter
- p.Ser94= Single submitter
Benign/Likely benign 1
- p.Phe393Leu Multiple submitters
Likely benign 5
- p.Arg10Trp Multiple submitters
- c.773-20C>T Single submitter
- p.Arg219His Single submitter ⚠
- p.Arg356His Single submitter ⚠
- c.451-29G>A No assertion criteria
Uncertain significance 59
- c.640-3_641dup Single submitter
- p.Ala11Glu Single submitter ⚠
- p.Ala272Val Single submitter ⚠
- p.Ala336Thr Single submitter ⚠
- p.Ala336Val Single submitter ⚠
- p.Arg109Trp Single submitter ⚠
- p.Arg129His Single submitter ⚠
- p.Arg241His Single submitter ⚠
- p.Arg254Gln Single submitter ⚠
- p.Arg356Cys Single submitter ⚠
- p.Arg5Trp Single submitter ⚠
- p.Asp298His Single submitter ⚠
- p.Asp421Gly Single submitter ⚠
- p.Asp54Asn Single submitter ⚠
- p.Cys159Arg Single submitter ⚠
- p.Cys388Phe Single submitter ⚠
- p.Cys388Ser Single submitter ⚠
- p.Gln227Glu Single submitter ⚠
- p.Gln248Arg Single submitter ⚠
- p.Gln249Lys Single submitter ⚠
- p.Gln368His Single submitter ⚠
- p.Gln407His Single submitter ⚠
- p.Gln407Lys Single submitter ⚠
- p.Gln98His Single submitter ⚠
- p.Gln98Pro Single submitter ⚠
- p.Glu168Lys Single submitter ⚠
- p.Glu174Asp Single submitter ⚠
- p.Glu178Lys Single submitter ⚠
- p.Glu192Lys Single submitter ⚠
- p.Glu332Lys Single submitter ⚠
- p.Glu359Lys Single submitter ⚠
- p.Glu71Ala Single submitter ⚠
- p.Gly245Arg Single submitter ⚠
- p.Gly257Glu Single submitter ⚠
- p.Gly302Ala Single submitter ⚠
- p.Gly419Arg Single submitter ⚠
- p.Gly89Ser Single submitter ⚠
- p.His216Gln Single submitter ⚠
- p.Ile246Ser Single submitter ⚠
- p.Ile312Val Single submitter ⚠
- p.Leu111Phe Single submitter ⚠
- p.Leu372Arg Single submitter ⚠
- p.Phe122Leu Single submitter ⚠
- p.Pro132Ala Single submitter ⚠
- p.Pro155Leu Single submitter ⚠
- p.Pro173Ser Single submitter ⚠
- p.Pro226Ser Single submitter ⚠
- p.Pro339Leu Single submitter ⚠
- p.Pro410Leu Single submitter ⚠
- p.Thr269Ile Single submitter ⚠
- p.Thr358Ile Single submitter ⚠
- p.Thr379Ile Single submitter ⚠
- p.Thr37Ser Single submitter ⚠
- p.Tyr207Cys Single submitter ⚠
- p.Val100Phe Single submitter ⚠
- p.Val361Ile Single submitter ⚠
- p.Val381Ala Single submitter ⚠
- p.Val402Ile Single submitter ⚠
- p.Gly89Asp No assertion criteria ⚠