ACTL10 — 62 ClinVar variants
All ClinVar germline ACTL10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 57 flagged for review →
7 Likely benign · 55 Uncertain significance
Full ACTL10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 57
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ACTL10 p.Ala176Pro Uncertain significance Single submitter
- ACTL10 p.Ala193Glu Uncertain significance Single submitter
- ACTL10 p.Ala193Pro Uncertain significance Single submitter
- ACTL10 p.Ala34Glu Uncertain significance Single submitter
- ACTL10 p.Ala71Val Uncertain significance Single submitter
- ACTL10 p.Arg188Gln Uncertain significance Single submitter
- ACTL10 p.Arg224Gly Uncertain significance Single submitter
- ACTL10 p.Arg225Gly Uncertain significance Single submitter
- ACTL10 p.Arg57Gln Uncertain significance Single submitter
- ACTL10 p.Asn64His Uncertain significance Single submitter
- ACTL10 p.Asp180Gly Uncertain significance Single submitter
- ACTL10 p.Glu137Asp Uncertain significance Single submitter
- ACTL10 p.Glu184Asp Uncertain significance Single submitter
- ACTL10 p.Glu92Asp Uncertain significance Single submitter
- ACTL10 p.Gly131Asp Uncertain significance Single submitter
- ACTL10 p.Gly167Ser Uncertain significance Single submitter
- ACTL10 p.Gly17Arg Uncertain significance Single submitter
- ACTL10 p.Gly17Val Uncertain significance Single submitter
- ACTL10 p.Gly204Arg Uncertain significance Single submitter
- ACTL10 p.Gly206Arg Uncertain significance Single submitter
- ACTL10 p.Leu219Pro Uncertain significance Single submitter
- ACTL10 p.Lys75Arg Uncertain significance Single submitter
- ACTL10 p.Pro130Gln Uncertain significance Single submitter
- ACTL10 p.Val114Ile Uncertain significance Single submitter
Predictors split 33
The independent predictors disagree with each other — read with care.
- ACTL10 p.Ala136Val Uncertain significance Single submitter
- ACTL10 p.Ala142Thr Likely benign Single submitter
- ACTL10 p.Ala22Ser Uncertain significance Single submitter
- ACTL10 p.Ala24Val Uncertain significance Single submitter
- ACTL10 p.Ala2Gly Uncertain significance Single submitter
- ACTL10 p.Ala62Val Uncertain significance Single submitter
- ACTL10 p.Arg188Gly Uncertain significance Single submitter
- ACTL10 p.Arg229Pro Uncertain significance Single submitter
- ACTL10 p.Arg74Pro Uncertain significance Single submitter
- ACTL10 p.Arg96Cys Uncertain significance Single submitter
- ACTL10 p.Asp58Tyr Uncertain significance Single submitter
- ACTL10 p.Cys112Tyr Uncertain significance Single submitter
- ACTL10 p.Cys27Arg Uncertain significance Single submitter
- ACTL10 p.Glu177Gly Uncertain significance Single submitter
- ACTL10 p.Glu234Ala Uncertain significance Single submitter
- ACTL10 p.Gly111Arg Uncertain significance Single submitter
- ACTL10 p.Gly23Ser Uncertain significance Single submitter
- ACTL10 p.Leu171Gln Uncertain significance Single submitter
- ACTL10 p.Leu59Gln Uncertain significance Single submitter
- ACTL10 p.Phe15Leu Likely benign Single submitter
- ACTL10 p.Pro31Ala Uncertain significance Single submitter
- ACTL10 p.Pro65His Uncertain significance Single submitter
- ACTL10 p.Pro65Thr Uncertain significance Single submitter
- ACTL10 p.Ser107Gly Uncertain significance Single submitter
- ACTL10 p.Ser53Trp Uncertain significance Single submitter
- ACTL10 p.Thr211Ser Uncertain significance Single submitter
- ACTL10 p.Thr78Ile Uncertain significance Single submitter
- ACTL10 p.Tyr33Cys Uncertain significance Single submitter
- ACTL10 p.Val163Ala Uncertain significance Single submitter
- ACTL10 p.Val164Leu Uncertain significance Single submitter
- ACTL10 p.Val164Met Uncertain significance Single submitter
- ACTL10 p.Val209Gly Uncertain significance Single submitter
- ACTL10 p.Val20Ala Uncertain significance Single submitter
All ACTL10 variants
Likely benign 7
- p.Ala142Thr Single submitter ⚠
- p.Ala76Thr Single submitter
- p.His28= Single submitter
- p.Ile77Val Single submitter
- p.Met207Thr Single submitter
- p.Phe15Leu Single submitter ⚠
- p.Val108Leu Single submitter
Uncertain significance 55
- p.Ala136Val Single submitter ⚠
- p.Ala176Pro Single submitter ⚠
- p.Ala193Glu Single submitter ⚠
- p.Ala193Pro Single submitter ⚠
- p.Ala22Ser Single submitter ⚠
- p.Ala24Val Single submitter ⚠
- p.Ala2Gly Single submitter ⚠
- p.Ala34Glu Single submitter ⚠
- p.Ala62Val Single submitter ⚠
- p.Ala71Val Single submitter ⚠
- p.Arg188Gln Single submitter ⚠
- p.Arg188Gly Single submitter ⚠
- p.Arg224Gly Single submitter ⚠
- p.Arg225Gly Single submitter ⚠
- p.Arg229Pro Single submitter ⚠
- p.Arg57Gln Single submitter ⚠
- p.Arg74Pro Single submitter ⚠
- p.Arg96Cys Single submitter ⚠
- p.Asn64His Single submitter ⚠
- p.Asp180Gly Single submitter ⚠
- p.Asp58Tyr Single submitter ⚠
- p.Cys112Tyr Single submitter ⚠
- p.Cys27Arg Single submitter ⚠
- p.Glu137Asp Single submitter ⚠
- p.Glu177Gly Single submitter ⚠
- p.Glu184Asp Single submitter ⚠
- p.Glu234Ala Single submitter ⚠
- p.Glu92Asp Single submitter ⚠
- p.Gly111Arg Single submitter ⚠
- p.Gly131Asp Single submitter ⚠
- p.Gly167Ser Single submitter ⚠
- p.Gly17Arg Single submitter ⚠
- p.Gly17Val Single submitter ⚠
- p.Gly204Arg Single submitter ⚠
- p.Gly206Arg Single submitter ⚠
- p.Gly23Ser Single submitter ⚠
- p.Leu171Gln Single submitter ⚠
- p.Leu219Pro Single submitter ⚠
- p.Leu59Gln Single submitter ⚠
- p.Lys75Arg Single submitter ⚠
- p.Pro130Gln Single submitter ⚠
- p.Pro31Ala Single submitter ⚠
- p.Pro65His Single submitter ⚠
- p.Pro65Thr Single submitter ⚠
- p.Ser107Gly Single submitter ⚠
- p.Ser53Trp Single submitter ⚠
- p.Thr211Ser Single submitter ⚠
- p.Thr78Ile Single submitter ⚠
- p.Tyr33Cys Single submitter ⚠
- p.Val114Ile Single submitter ⚠
- p.Val163Ala Single submitter ⚠
- p.Val164Leu Single submitter ⚠
- p.Val164Met Single submitter ⚠
- p.Val209Gly Single submitter ⚠
- p.Val20Ala Single submitter ⚠