ACTR3C — 34 ClinVar variants
All ClinVar germline ACTR3C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 28 flagged for review →
1 Benign · 33 Uncertain significance
Full ACTR3C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 28
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ACTR3C p.Ala132Val Uncertain significance Single submitter
- ACTR3C p.Arg32Pro Uncertain significance Single submitter
- ACTR3C p.Asn160Ile Uncertain significance Single submitter
- ACTR3C p.Asp108Asn Uncertain significance Single submitter
- ACTR3C p.Glu165Gly Uncertain significance Single submitter
- ACTR3C p.Glu173Ala Uncertain significance Single submitter
- ACTR3C p.Ile12Thr Uncertain significance Single submitter
- ACTR3C p.Ile12Val Uncertain significance Single submitter
- ACTR3C p.Ile130Val Uncertain significance Single submitter
- ACTR3C p.Ile37Arg Uncertain significance Single submitter
- ACTR3C p.Ile71Thr Uncertain significance Single submitter
- ACTR3C p.Lys137Thr Uncertain significance Single submitter
- ACTR3C p.Lys188Gln Uncertain significance Single submitter
- ACTR3C p.Met164Ile Uncertain significance Single submitter
- ACTR3C p.Phe154Leu Uncertain significance Single submitter
- ACTR3C p.Pro185Ser Uncertain significance Single submitter
- ACTR3C p.Val48Ile Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- ACTR3C p.Arg183Gln Uncertain significance Single submitter
- ACTR3C p.Asp108His Uncertain significance Single submitter
- ACTR3C p.Gln90Glu Uncertain significance Single submitter
- ACTR3C p.Glu31Lys Uncertain significance Single submitter
- ACTR3C p.Ile98Asn Uncertain significance Single submitter
- ACTR3C p.Pro185Leu Uncertain significance Single submitter
- ACTR3C p.Pro65Leu Uncertain significance Single submitter
- ACTR3C p.Pro87Leu Uncertain significance Single submitter
- ACTR3C p.Thr72Ala Uncertain significance Single submitter
- ACTR3C p.Trp123Cys Uncertain significance Single submitter
- ACTR3C p.Val7Leu Uncertain significance Single submitter
All ACTR3C variants
Benign 1
- p.Gln121Ter Multiple submitters
Uncertain significance 33
- p.Ala132Val Single submitter ⚠
- p.Ala21Val Single submitter
- p.Ala52Gly Single submitter
- p.Arg183Gln Single submitter ⚠
- p.Arg32Cys Single submitter
- p.Arg32Pro Single submitter ⚠
- p.Asn160Ile Single submitter ⚠
- p.Asp108Asn Single submitter ⚠
- p.Asp108His Single submitter ⚠
- p.Gln90Glu Single submitter ⚠
- p.Glu165Gly Single submitter ⚠
- p.Glu173Ala Single submitter ⚠
- p.Glu31Lys Single submitter ⚠
- p.Glu89Gly Single submitter
- p.Ile12Thr Single submitter ⚠
- p.Ile12Val Single submitter ⚠
- p.Ile130Val Single submitter ⚠
- p.Ile37Arg Single submitter ⚠
- p.Ile71Thr Single submitter ⚠
- p.Ile98Asn Single submitter ⚠
- p.Lys115Thr Single submitter
- p.Lys137Thr Single submitter ⚠
- p.Lys188Gln Single submitter ⚠
- p.Met164Ile Single submitter ⚠
- p.Phe154Leu Single submitter ⚠
- p.Pro185Leu Single submitter ⚠
- p.Pro185Ser Single submitter ⚠
- p.Pro65Leu Single submitter ⚠
- p.Pro87Leu Single submitter ⚠
- p.Thr72Ala Single submitter ⚠
- p.Trp123Cys Single submitter ⚠
- p.Val48Ile Single submitter ⚠
- p.Val7Leu Single submitter ⚠