ADAM2 — 108 ClinVar variants
All ClinVar germline ADAM2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 103 flagged for review →
7 Likely benign · 101 Uncertain significance
Full ADAM2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 103
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 67
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADAM2 p.Ala238Val Uncertain significance Single submitter
- ADAM2 p.Ala289Val Uncertain significance Single submitter
- ADAM2 p.Ala334Thr Uncertain significance Single submitter
- ADAM2 p.Ala668Val Uncertain significance Single submitter
- ADAM2 p.Arg161Gly Uncertain significance Single submitter
- ADAM2 p.Arg261Cys Uncertain significance Single submitter
- ADAM2 p.Arg717Lys Uncertain significance Single submitter
- ADAM2 p.Asn122Asp Uncertain significance Single submitter
- ADAM2 p.Asn290Ile Uncertain significance Single submitter
- ADAM2 p.Asp17Glu Uncertain significance Single submitter
- ADAM2 p.Asp233Glu Uncertain significance Single submitter
- ADAM2 p.Asp453Val Uncertain significance Single submitter
- ADAM2 p.Asp538Asn Uncertain significance Single submitter
- ADAM2 p.Asp623Gly Uncertain significance Single submitter
- ADAM2 p.Asp724Asn Uncertain significance Single submitter
- ADAM2 p.Cys111Trp Uncertain significance Single submitter
- ADAM2 p.Cys336Arg Uncertain significance Single submitter
- ADAM2 p.Cys413Arg Uncertain significance Single submitter
- ADAM2 p.Cys465Arg Uncertain significance Single submitter
- ADAM2 p.Cys606Arg Uncertain significance Single submitter
- ADAM2 p.Cys606Tyr Uncertain significance Single submitter
- ADAM2 p.Cys621Arg Uncertain significance Single submitter
- ADAM2 p.Gln330Arg Uncertain significance Single submitter
- ADAM2 p.Gln86Arg Uncertain significance Single submitter
- ADAM2 p.Glu725Lys Uncertain significance Single submitter
- ADAM2 p.Gly116Asp Uncertain significance Single submitter
- ADAM2 p.Gly12Ser Uncertain significance Single submitter
- ADAM2 p.Gly347Asp Uncertain significance Single submitter
- ADAM2 p.Gly401Arg Uncertain significance Single submitter
- ADAM2 p.Gly543Arg Uncertain significance Single submitter
- ADAM2 p.Gly77Ser Uncertain significance Single submitter
- ADAM2 p.His145Arg Uncertain significance Single submitter
- ADAM2 p.His681Asp Uncertain significance Single submitter
- ADAM2 p.Ile215Leu Uncertain significance Single submitter
- ADAM2 p.Ile232Thr Uncertain significance Single submitter
- ADAM2 p.Ile350Phe Uncertain significance Single submitter
- ADAM2 p.Leu246Ser Uncertain significance Single submitter
- ADAM2 p.Lys734Arg Uncertain significance Single submitter
- ADAM2 p.Met16Lys Uncertain significance Single submitter
- ADAM2 p.Met286Thr Uncertain significance Single submitter
- ADAM2 p.Met319Leu Uncertain significance Single submitter
- ADAM2 p.Met490Ile Uncertain significance Single submitter
- ADAM2 p.Met61Arg Uncertain significance Single submitter
- ADAM2 p.Met61Lys Uncertain significance Single submitter
- ADAM2 p.Phe689Ser Uncertain significance Single submitter
- ADAM2 p.Phe699Cys Uncertain significance Single submitter
- ADAM2 p.Phe711Ile Uncertain significance Single submitter
- ADAM2 p.Pro55Arg Uncertain significance Single submitter
- ADAM2 p.Pro688Ala Uncertain significance Single submitter
- ADAM2 p.Pro733His Uncertain significance Single submitter
- ADAM2 p.Ser22Asn Uncertain significance Single submitter
- ADAM2 p.Ser355Arg Uncertain significance Single submitter
- ADAM2 p.Ser655Thr Uncertain significance Single submitter
- ADAM2 p.Thr212Met Uncertain significance Single submitter
- ADAM2 p.Thr222Ile Uncertain significance Single submitter
- ADAM2 p.Thr617Ala Uncertain significance Single submitter
- ADAM2 p.Thr617Ile Uncertain significance Single submitter
- ADAM2 p.Tyr153Cys Uncertain significance Single submitter
- ADAM2 p.Tyr323Phe Uncertain significance Single submitter
- ADAM2 p.Tyr675Asn Uncertain significance Single submitter
- ADAM2 p.Tyr721Cys Uncertain significance Single submitter
- ADAM2 p.Val117Ile Uncertain significance Single submitter
- ADAM2 p.Val170Leu Uncertain significance Single submitter
- ADAM2 p.Val278Ala Uncertain significance Single submitter
- ADAM2 p.Val521Gly Uncertain significance Single submitter
- ADAM2 p.Val521Ile Uncertain significance Single submitter
- ADAM2 p.Val550Ile Uncertain significance Single submitter
Predictors split 36
The independent predictors disagree with each other — read with care.
- ADAM2 p.Ala266Gly Uncertain significance Single submitter
- ADAM2 p.Ala463Val Uncertain significance Single submitter
- ADAM2 p.Arg252Gly Uncertain significance Single submitter
- ADAM2 p.Arg34Trp Uncertain significance Single submitter
- ADAM2 p.Asp520Gly Uncertain significance Single submitter
- ADAM2 p.Glu510Gln Uncertain significance Single submitter
- ADAM2 p.Glu99Gly Uncertain significance Single submitter
- ADAM2 p.Gly395Val Uncertain significance Single submitter
- ADAM2 p.Gly424Ser Uncertain significance Single submitter
- ADAM2 p.Gly523Glu Uncertain significance Single submitter
- ADAM2 p.Gly596Ala Uncertain significance Single submitter
- ADAM2 p.Ile51Leu Uncertain significance Single submitter
- ADAM2 p.Ile656Thr Uncertain significance Single submitter
- ADAM2 p.Leu408Pro Uncertain significance Single submitter
- ADAM2 p.Leu479Pro Likely benign Single submitter
- ADAM2 p.Leu554Phe Uncertain significance Single submitter
- ADAM2 p.Lys285Asn Uncertain significance Single submitter
- ADAM2 p.Lys38Met Uncertain significance Single submitter
- ADAM2 p.Lys548Thr Uncertain significance Single submitter
- ADAM2 p.Lys586Asn Uncertain significance Single submitter
- ADAM2 p.Lys714Glu Uncertain significance Single submitter
- ADAM2 p.Lys82Asn Uncertain significance Single submitter
- ADAM2 p.Phe690Ser Uncertain significance Single submitter
- ADAM2 p.Pro262Leu Uncertain significance Single submitter
- ADAM2 p.Pro262Thr Uncertain significance Single submitter
- ADAM2 p.Pro83Leu Uncertain significance Single submitter
- ADAM2 p.Ser316Arg Uncertain significance Single submitter
- ADAM2 p.Ser318Gly Uncertain significance Single submitter
- ADAM2 p.Ser74Ile Uncertain significance Single submitter
- ADAM2 p.Thr281Asn Uncertain significance Single submitter
- ADAM2 p.Thr281Ser Uncertain significance Single submitter
- ADAM2 p.Thr57Ala Uncertain significance Single submitter
- ADAM2 p.Tyr141Cys Uncertain significance Single submitter
- ADAM2 p.Val205Phe Uncertain significance Single submitter
- ADAM2 p.Val550Glu Uncertain significance Single submitter
- ADAM2 p.Val575Leu Likely benign Single submitter
All ADAM2 variants
Likely benign 7
- p.Asp623Asn Single submitter
- p.Gln541Lys Single submitter
- p.Glu442Gly Single submitter
- p.Ile416Thr Single submitter
- p.Leu479Pro Single submitter ⚠
- p.Met16Thr Single submitter
- p.Val575Leu Single submitter ⚠
Uncertain significance 101
- p.Ala238Val Single submitter ⚠
- p.Ala266Gly Single submitter ⚠
- p.Ala289Val Single submitter ⚠
- p.Ala334Thr Single submitter ⚠
- p.Ala463Val Single submitter ⚠
- p.Ala668Val Single submitter ⚠
- p.Arg161Gly Single submitter ⚠
- p.Arg252Gly Single submitter ⚠
- p.Arg261Cys Single submitter ⚠
- p.Arg34Trp Single submitter ⚠
- p.Arg717Lys Single submitter ⚠
- p.Asn122Asp Single submitter ⚠
- p.Asn290Ile Single submitter ⚠
- p.Asp17Glu Single submitter ⚠
- p.Asp233Glu Single submitter ⚠
- p.Asp453Val Single submitter ⚠
- p.Asp520Gly Single submitter ⚠
- p.Asp538Asn Single submitter ⚠
- p.Asp623Gly Single submitter ⚠
- p.Asp724Asn Single submitter ⚠
- p.Cys111Trp Single submitter ⚠
- p.Cys336Arg Single submitter ⚠
- p.Cys413Arg Single submitter ⚠
- p.Cys465Arg Single submitter ⚠
- p.Cys606Arg Single submitter ⚠
- p.Cys606Tyr Single submitter ⚠
- p.Cys621Arg Single submitter ⚠
- p.Gln330Arg Single submitter ⚠
- p.Gln86Arg Single submitter ⚠
- p.Glu510Gln Single submitter ⚠
- p.Glu725Lys Single submitter ⚠
- p.Glu99Gly Single submitter ⚠
- p.Gly116Asp Single submitter ⚠
- p.Gly12Ser Single submitter ⚠
- p.Gly347Asp Single submitter ⚠
- p.Gly395Val Single submitter ⚠
- p.Gly401Arg Single submitter ⚠
- p.Gly424Ser Single submitter ⚠
- p.Gly523Glu Single submitter ⚠
- p.Gly543Arg Single submitter ⚠
- p.Gly596Ala Single submitter ⚠
- p.Gly77Ser Single submitter ⚠
- p.His145Arg Single submitter ⚠
- p.His681Asp Single submitter ⚠
- p.Ile215Leu Single submitter ⚠
- p.Ile232Thr Single submitter ⚠
- p.Ile350Phe Single submitter ⚠
- p.Ile51Leu Single submitter ⚠
- p.Ile656Thr Single submitter ⚠
- p.Leu246Ser Single submitter ⚠
- p.Leu408Pro Single submitter ⚠
- p.Leu554Phe Single submitter ⚠
- p.Lys285Asn Single submitter ⚠
- p.Lys38Met Single submitter ⚠
- p.Lys548Thr Single submitter ⚠
- p.Lys586Asn Single submitter ⚠
- p.Lys714Glu Single submitter ⚠
- p.Lys734Arg Single submitter ⚠
- p.Lys82Asn Single submitter ⚠
- p.Met16Lys Single submitter ⚠
- p.Met286Thr Single submitter ⚠
- p.Met319Leu Single submitter ⚠
- p.Met490Ile Single submitter ⚠
- p.Met61Arg Single submitter ⚠
- p.Met61Lys Single submitter ⚠
- p.Phe689Ser Single submitter ⚠
- p.Phe690Ser Single submitter ⚠
- p.Phe699Cys Single submitter ⚠
- p.Phe711Ile Single submitter ⚠
- p.Pro262Leu Single submitter ⚠
- p.Pro262Thr Single submitter ⚠
- p.Pro55Arg Single submitter ⚠
- p.Pro688Ala Single submitter ⚠
- p.Pro733His Single submitter ⚠
- p.Pro83Leu Single submitter ⚠
- p.Ser22Asn Single submitter ⚠
- p.Ser316Arg Single submitter ⚠
- p.Ser318Gly Single submitter ⚠
- p.Ser355Arg Single submitter ⚠
- p.Ser655Thr Single submitter ⚠
- p.Ser74Ile Single submitter ⚠
- p.Thr212Met Single submitter ⚠
- p.Thr222Ile Single submitter ⚠
- p.Thr281Asn Single submitter ⚠
- p.Thr281Ser Single submitter ⚠
- p.Thr57Ala Single submitter ⚠
- p.Thr617Ala Single submitter ⚠
- p.Thr617Ile Single submitter ⚠
- p.Tyr141Cys Single submitter ⚠
- p.Tyr153Cys Single submitter ⚠
- p.Tyr323Phe Single submitter ⚠
- p.Tyr675Asn Single submitter ⚠
- p.Tyr721Cys Single submitter ⚠
- p.Val117Ile Single submitter ⚠
- p.Val170Leu Single submitter ⚠
- p.Val205Phe Single submitter ⚠
- p.Val278Ala Single submitter ⚠
- p.Val521Gly Single submitter ⚠
- p.Val521Ile Single submitter ⚠
- p.Val550Glu Single submitter ⚠
- p.Val550Ile Single submitter ⚠