ADAM21 — 106 ClinVar variants
All ClinVar germline ADAM21 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 98 flagged for review →
9 Likely benign · 97 Uncertain significance
Full ADAM21 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 98
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 50
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADAM21 p.Ala432Asp Uncertain significance Single submitter
- ADAM21 p.Ala432Thr Uncertain significance Single submitter
- ADAM21 p.Ala500Ser Uncertain significance Single submitter
- ADAM21 p.Ala718Pro Uncertain significance Single submitter
- ADAM21 p.Arg408His Uncertain significance Single submitter
- ADAM21 p.Asn277Lys Uncertain significance Single submitter
- ADAM21 p.Asn567Ser Uncertain significance Single submitter
- ADAM21 p.Asn586Ser Uncertain significance Single submitter
- ADAM21 p.Asp107Gly Uncertain significance Single submitter
- ADAM21 p.Asp219Glu Uncertain significance Single submitter
- ADAM21 p.Asp570Glu Uncertain significance Single submitter
- ADAM21 p.Cys29Tyr Uncertain significance Single submitter
- ADAM21 p.Cys358Gly Uncertain significance Single submitter
- ADAM21 p.Cys433Ser Uncertain significance Single submitter
- ADAM21 p.Cys502Arg Uncertain significance Single submitter
- ADAM21 p.Cys507Tyr Uncertain significance Single submitter
- ADAM21 p.Gln102Lys Uncertain significance Single submitter
- ADAM21 p.Gln183Lys Uncertain significance Single submitter
- ADAM21 p.Gln527His Uncertain significance Single submitter
- ADAM21 p.Gly140Ser Uncertain significance Single submitter
- ADAM21 p.Gly308Val Uncertain significance Single submitter
- ADAM21 p.Gly344Arg Uncertain significance Single submitter
- ADAM21 p.Gly479Glu Uncertain significance Single submitter
- ADAM21 p.Gly616Glu Uncertain significance Single submitter
- ADAM21 p.Gly712Arg Uncertain significance Single submitter
- ADAM21 p.His351Arg Uncertain significance Single submitter
- ADAM21 p.His395Gln Uncertain significance Single submitter
- ADAM21 p.His632Leu Uncertain significance Single submitter
- ADAM21 p.His664Gln Uncertain significance Single submitter
- ADAM21 p.His719Leu Uncertain significance Single submitter
- ADAM21 p.Ile299Thr Uncertain significance Single submitter
- ADAM21 p.Ile299Val Uncertain significance Single submitter
- ADAM21 p.Ile571Phe Uncertain significance Single submitter
- ADAM21 p.Ile601Val Uncertain significance Single submitter
- ADAM21 p.Leu303Arg Uncertain significance Single submitter
- ADAM21 p.Leu406Val Uncertain significance Single submitter
- ADAM21 p.Leu573Val Uncertain significance Single submitter
- ADAM21 p.Leu692Val Uncertain significance Single submitter
- ADAM21 p.Lys608Arg Uncertain significance Single submitter
- ADAM21 p.Lys714Arg Uncertain significance Single submitter
- ADAM21 p.Met171Thr Uncertain significance Single submitter
- ADAM21 p.Met269Val Uncertain significance Single submitter
- ADAM21 p.Pro685Leu Uncertain significance Single submitter
- ADAM21 p.Ser50Arg Uncertain significance Single submitter
- ADAM21 p.Ser50Gly Uncertain significance Single submitter
- ADAM21 p.Thr270Lys Uncertain significance Single submitter
- ADAM21 p.Val180Leu Uncertain significance Single submitter
- ADAM21 p.Val588Ile Uncertain significance Single submitter
- ADAM21 p.Val612Leu Uncertain significance Single submitter
- ADAM21 p.Val73Leu Uncertain significance Single submitter
Predictors split 48
The independent predictors disagree with each other — read with care.
- ADAM21 p.Arg182Cys Uncertain significance Single submitter
- ADAM21 p.Arg317Cys Uncertain significance Single submitter
- ADAM21 p.Arg539His Uncertain significance Single submitter
- ADAM21 p.Arg539Ser Uncertain significance Single submitter
- ADAM21 p.Arg96Cys Uncertain significance Single submitter
- ADAM21 p.Asn546Lys Uncertain significance Single submitter
- ADAM21 p.Asn640Ser Uncertain significance Single submitter
- ADAM21 p.Asp243Tyr Uncertain significance Single submitter
- ADAM21 p.Asp487Glu Uncertain significance Single submitter
- ADAM21 p.Asp521Tyr Uncertain significance Single submitter
- ADAM21 p.Asp557Glu Uncertain significance Single submitter
- ADAM21 p.Asp557Tyr Uncertain significance Single submitter
- ADAM21 p.Asp557Val Uncertain significance Single submitter
- ADAM21 p.Cys322Phe Uncertain significance Single submitter
- ADAM21 p.Gln284His Uncertain significance Single submitter
- ADAM21 p.Glu637Asp Uncertain significance Single submitter
- ADAM21 p.Gly544Asp Uncertain significance Single submitter
- ADAM21 p.Gly592Asp Uncertain significance Single submitter
- ADAM21 p.Gly666Asp Uncertain significance Single submitter
- ADAM21 p.His296Arg Uncertain significance Single submitter
- ADAM21 p.His296Pro Uncertain significance Single submitter
- ADAM21 p.His482Leu Uncertain significance Single submitter
- ADAM21 p.Ile241Arg Uncertain significance Single submitter
- ADAM21 p.Ile253Leu Uncertain significance Single submitter
- ADAM21 p.Ile258Thr Uncertain significance Single submitter
- ADAM21 p.Ile304Lys Uncertain significance Single submitter
- ADAM21 p.Ile618Thr Uncertain significance Single submitter
- ADAM21 p.Ile644Ser Uncertain significance Single submitter
- ADAM21 p.Leu276Arg Uncertain significance Single submitter
- ADAM21 p.Leu435Pro Uncertain significance Single submitter
- ADAM21 p.Leu440Pro Uncertain significance Single submitter
- ADAM21 p.Leu46Phe Uncertain significance Single submitter
- ADAM21 p.Leu98Phe Uncertain significance Single submitter
- ADAM21 p.Lys47Thr Uncertain significance Single submitter
- ADAM21 p.Met245Thr Uncertain significance Single submitter
- ADAM21 p.Met297Thr Uncertain significance Single submitter
- ADAM21 p.Pro485Ala Uncertain significance Single submitter
- ADAM21 p.Pro485Ser Uncertain significance Single submitter
- ADAM21 p.Thr386Ala Uncertain significance Single submitter
- ADAM21 p.Thr386Ser Uncertain significance Single submitter
- ADAM21 p.Thr439Ile Uncertain significance Single submitter
- ADAM21 p.Tyr503Cys Uncertain significance Single submitter
- ADAM21 p.Tyr706His Uncertain significance Single submitter
- ADAM21 p.Val312Ile Likely benign Single submitter
- ADAM21 p.Val339Ala Uncertain significance Single submitter
- ADAM21 p.Val42Leu Uncertain significance Single submitter
- ADAM21 p.Val48Glu Uncertain significance Single submitter
- ADAM21 p.Val48Met Uncertain significance Single submitter
All ADAM21 variants
Likely benign 9
- p.Arg133Gln Single submitter
- p.Arg317His Single submitter
- p.Gln426Lys Single submitter
- p.Gly681Arg Single submitter
- p.Met245Ile Single submitter
- p.Phe697Leu Single submitter
- p.Val180Ile Single submitter
- p.Val312Ile Single submitter ⚠
- p.Val73Ile Single submitter
Uncertain significance 97
- p.Ala432Asp Single submitter ⚠
- p.Ala432Thr Single submitter ⚠
- p.Ala500Ser Single submitter ⚠
- p.Ala718Pro Single submitter ⚠
- p.Arg182Cys Single submitter ⚠
- p.Arg317Cys Single submitter ⚠
- p.Arg408His Single submitter ⚠
- p.Arg539His Single submitter ⚠
- p.Arg539Ser Single submitter ⚠
- p.Arg96Cys Single submitter ⚠
- p.Asn277Lys Single submitter ⚠
- p.Asn546Lys Single submitter ⚠
- p.Asn567Ser Single submitter ⚠
- p.Asn586Ser Single submitter ⚠
- p.Asn640Ser Single submitter ⚠
- p.Asp107Gly Single submitter ⚠
- p.Asp219Glu Single submitter ⚠
- p.Asp243Tyr Single submitter ⚠
- p.Asp487Glu Single submitter ⚠
- p.Asp521Tyr Single submitter ⚠
- p.Asp557Glu Single submitter ⚠
- p.Asp557Tyr Single submitter ⚠
- p.Asp557Val Single submitter ⚠
- p.Asp570Glu Single submitter ⚠
- p.Cys29Tyr Single submitter ⚠
- p.Cys322Phe Single submitter ⚠
- p.Cys358Gly Single submitter ⚠
- p.Cys433Ser Single submitter ⚠
- p.Cys502Arg Single submitter ⚠
- p.Cys507Tyr Single submitter ⚠
- p.Gln102Lys Single submitter ⚠
- p.Gln183Lys Single submitter ⚠
- p.Gln284His Single submitter ⚠
- p.Gln527His Single submitter ⚠
- p.Glu637Asp Single submitter ⚠
- p.Gly140Ser Single submitter ⚠
- p.Gly308Val Single submitter ⚠
- p.Gly344Arg Single submitter ⚠
- p.Gly479Glu Single submitter ⚠
- p.Gly544Asp Single submitter ⚠
- p.Gly592Asp Single submitter ⚠
- p.Gly616Glu Single submitter ⚠
- p.Gly666Asp Single submitter ⚠
- p.Gly712Arg Single submitter ⚠
- p.His296Arg Single submitter ⚠
- p.His296Pro Single submitter ⚠
- p.His351Arg Single submitter ⚠
- p.His395Gln Single submitter ⚠
- p.His482Leu Single submitter ⚠
- p.His632Leu Single submitter ⚠
- p.His664Gln Single submitter ⚠
- p.His719Leu Single submitter ⚠
- p.Ile241Arg Single submitter ⚠
- p.Ile253Leu Single submitter ⚠
- p.Ile258Thr Single submitter ⚠
- p.Ile299Thr Single submitter ⚠
- p.Ile299Val Single submitter ⚠
- p.Ile304Lys Single submitter ⚠
- p.Ile571Phe Single submitter ⚠
- p.Ile601Val Single submitter ⚠
- p.Ile618Thr Single submitter ⚠
- p.Ile644Ser Single submitter ⚠
- p.Leu276Arg Single submitter ⚠
- p.Leu303Arg Single submitter ⚠
- p.Leu406Val Single submitter ⚠
- p.Leu435Pro Single submitter ⚠
- p.Leu440Pro Single submitter ⚠
- p.Leu46Phe Single submitter ⚠
- p.Leu573Val Single submitter ⚠
- p.Leu692Val Single submitter ⚠
- p.Leu98Phe Single submitter ⚠
- p.Lys47Thr Single submitter ⚠
- p.Lys608Arg Single submitter ⚠
- p.Lys714Arg Single submitter ⚠
- p.Met171Thr Single submitter ⚠
- p.Met245Thr Single submitter ⚠
- p.Met269Val Single submitter ⚠
- p.Met297Thr Single submitter ⚠
- p.Pro485Ala Single submitter ⚠
- p.Pro485Ser Single submitter ⚠
- p.Pro685Leu Single submitter ⚠
- p.Ser50Arg Single submitter ⚠
- p.Ser50Gly Single submitter ⚠
- p.Thr270Lys Single submitter ⚠
- p.Thr386Ala Single submitter ⚠
- p.Thr386Ser Single submitter ⚠
- p.Thr439Ile Single submitter ⚠
- p.Tyr503Cys Single submitter ⚠
- p.Tyr706His Single submitter ⚠
- p.Val180Leu Single submitter ⚠
- p.Val339Ala Single submitter ⚠
- p.Val42Leu Single submitter ⚠
- p.Val48Glu Single submitter ⚠
- p.Val48Met Single submitter ⚠
- p.Val588Ile Single submitter ⚠
- p.Val612Leu Single submitter ⚠
- p.Val73Leu Single submitter ⚠