ADAM32 — 117 ClinVar variants
All ClinVar germline ADAM32 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 102 flagged for review →
17 Likely benign · 100 Uncertain significance
Full ADAM32 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 102
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 56
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADAM32 p.Ala154Thr Uncertain significance Single submitter
- ADAM32 p.Ala179Ser Uncertain significance Single submitter
- ADAM32 p.Ala621Val Uncertain significance Single submitter
- ADAM32 p.Arg284His Uncertain significance Single submitter
- ADAM32 p.Arg501His Uncertain significance Single submitter
- ADAM32 p.Arg575Gln Uncertain significance Single submitter
- ADAM32 p.Asn354His Uncertain significance Single submitter
- ADAM32 p.Asn373Ser Uncertain significance Single submitter
- ADAM32 p.Asn39Asp Uncertain significance Single submitter
- ADAM32 p.Asp182His Uncertain significance Single submitter
- ADAM32 p.Asp200Glu Uncertain significance Single submitter
- ADAM32 p.Asp406Asn Uncertain significance Single submitter
- ADAM32 p.Cys295Tyr Uncertain significance Single submitter
- ADAM32 p.Cys337Tyr Uncertain significance Single submitter
- ADAM32 p.Cys344Tyr Uncertain significance Single submitter
- ADAM32 p.Cys362Tyr Uncertain significance Single submitter
- ADAM32 p.Cys378Arg Uncertain significance Single submitter
- ADAM32 p.Cys579Ser Uncertain significance Single submitter
- ADAM32 p.Gln386Glu Uncertain significance Single submitter
- ADAM32 p.Glu124Ala Uncertain significance Single submitter
- ADAM32 p.Glu237Ala Uncertain significance Single submitter
- ADAM32 p.Glu309Lys Uncertain significance Single submitter
- ADAM32 p.Glu45Gly Uncertain significance Single submitter
- ADAM32 p.Glu721Lys Uncertain significance Single submitter
- ADAM32 p.Gly20Asp Uncertain significance Single submitter
- ADAM32 p.Gly287Arg Uncertain significance Single submitter
- ADAM32 p.Gly567Ser Uncertain significance Single submitter
- ADAM32 p.His633Pro Uncertain significance Single submitter
- ADAM32 p.Ile120Val Uncertain significance Single submitter
- ADAM32 p.Ile208Thr Uncertain significance Single submitter
- ADAM32 p.Ile329Met Uncertain significance Single submitter
- ADAM32 p.Ile49Met Uncertain significance Single submitter
- ADAM32 p.Ile618Leu Uncertain significance Single submitter
- ADAM32 p.Ile662Thr Uncertain significance Single submitter
- ADAM32 p.Ile662Val Uncertain significance Single submitter
- ADAM32 p.Leu188Ile Uncertain significance Single submitter
- ADAM32 p.Leu198Ser Uncertain significance Single submitter
- ADAM32 p.Leu325Arg Uncertain significance Single submitter
- ADAM32 p.Leu481Phe Uncertain significance Single submitter
- ADAM32 p.Lys377Thr Uncertain significance Single submitter
- ADAM32 p.Lys597Glu Uncertain significance Single submitter
- ADAM32 p.Met385Ile Uncertain significance Single submitter
- ADAM32 p.Met385Thr Uncertain significance Single submitter
- ADAM32 p.Pro291Leu Uncertain significance Single submitter
- ADAM32 p.Pro392Ala Uncertain significance Single submitter
- ADAM32 p.Ser160Gly Uncertain significance Single submitter
- ADAM32 p.Ser353Ala Uncertain significance Single submitter
- ADAM32 p.Ser525Leu Uncertain significance Single submitter
- ADAM32 p.Ser577Tyr Uncertain significance Single submitter
- ADAM32 p.Thr358Ile Uncertain significance Single submitter
- ADAM32 p.Thr358Ser Uncertain significance Single submitter
- ADAM32 p.Thr589Arg Uncertain significance Single submitter
- ADAM32 p.Trp261Cys Uncertain significance Single submitter
- ADAM32 p.Val448Ile Uncertain significance Single submitter
- ADAM32 p.Val448Phe Uncertain significance Single submitter
- ADAM32 p.Val574Ile Uncertain significance Single submitter
Predictors split 46
The independent predictors disagree with each other — read with care.
- ADAM32 p.Arg298His Likely benign Multiple submitters
- ADAM32 p.Ala699Thr Uncertain significance Single submitter
- ADAM32 p.Arg501Cys Uncertain significance Single submitter
- ADAM32 p.Arg611Cys Uncertain significance Single submitter
- ADAM32 p.Arg656His Uncertain significance Single submitter
- ADAM32 p.Asn681Asp Uncertain significance Single submitter
- ADAM32 p.Asp241Gly Uncertain significance Single submitter
- ADAM32 p.Asp568Gly Uncertain significance Single submitter
- ADAM32 p.Asp576Val Uncertain significance Single submitter
- ADAM32 p.Gln321Lys Uncertain significance Single submitter
- ADAM32 p.Glu215Val Uncertain significance Single submitter
- ADAM32 p.Glu666Gln Uncertain significance Single submitter
- ADAM32 p.Gly129Val Uncertain significance Single submitter
- ADAM32 p.Gly397Asp Uncertain significance Single submitter
- ADAM32 p.Gly401Arg Uncertain significance Single submitter
- ADAM32 p.Gly429Arg Uncertain significance Single submitter
- ADAM32 p.His191Pro Uncertain significance Single submitter
- ADAM32 p.His271Leu Uncertain significance Single submitter
- ADAM32 p.His455Tyr Uncertain significance Single submitter
- ADAM32 p.His633Tyr Uncertain significance Single submitter
- ADAM32 p.Ile689Val Uncertain significance Single submitter
- ADAM32 p.Leu276Ile Uncertain significance Single submitter
- ADAM32 p.Leu552Phe Uncertain significance Single submitter
- ADAM32 p.Leu586Met Uncertain significance Single submitter
- ADAM32 p.Leu7Pro Uncertain significance Single submitter
- ADAM32 p.Lys439Arg Likely benign Single submitter
- ADAM32 p.Lys65Thr Uncertain significance Single submitter
- ADAM32 p.Lys775Ile Uncertain significance Single submitter
- ADAM32 p.Phe359Tyr Uncertain significance Single submitter
- ADAM32 p.Phe541Leu Uncertain significance Single submitter
- ADAM32 p.Pro348Leu Uncertain significance Single submitter
- ADAM32 p.Pro452Leu Uncertain significance Single submitter
- ADAM32 p.Pro514Leu Uncertain significance Single submitter
- ADAM32 p.Pro593Leu Uncertain significance Single submitter
- ADAM32 p.Pro651Gln Uncertain significance Single submitter
- ADAM32 p.Ser115Pro Uncertain significance Single submitter
- ADAM32 p.Ser50Cys Uncertain significance Single submitter
- ADAM32 p.Thr210Arg Uncertain significance Single submitter
- ADAM32 p.Thr409Ile Uncertain significance Single submitter
- ADAM32 p.Thr743Ala Uncertain significance Single submitter
- ADAM32 p.Thr758Ile Uncertain significance Single submitter
- ADAM32 p.Tyr199Cys Uncertain significance Single submitter
- ADAM32 p.Tyr285His Uncertain significance Single submitter
- ADAM32 p.Tyr306Asn Uncertain significance Single submitter
- ADAM32 p.Val193Ala Uncertain significance Single submitter
- ADAM32 p.Val194Met Uncertain significance Single submitter
All ADAM32 variants
Likely benign 17
- p.Arg298His Multiple submitters ⚠
- p.Arg511Lys Single submitter
- p.Asn354Ser Single submitter
- p.Ile580Val Single submitter
- p.Ile604Thr Single submitter
- p.Ile693Val Single submitter
- p.Leu59Pro Single submitter
- p.Lys377Arg Single submitter
- p.Lys439Arg Single submitter ⚠
- p.Lys760= Single submitter
- p.Met84Val Single submitter
- p.Thr358= Single submitter
- p.Trp17fs Single submitter
- p.Val213Ile Single submitter
- p.Val29Ile Single submitter
- p.Val303Ile Single submitter
- p.Val62= Single submitter
Uncertain significance 100
- p.Ala154Thr Single submitter ⚠
- p.Ala179Ser Single submitter ⚠
- p.Ala621Val Single submitter ⚠
- p.Ala699Thr Single submitter ⚠
- p.Arg284His Single submitter ⚠
- p.Arg501Cys Single submitter ⚠
- p.Arg501His Single submitter ⚠
- p.Arg575Gln Single submitter ⚠
- p.Arg611Cys Single submitter ⚠
- p.Arg656His Single submitter ⚠
- p.Asn354His Single submitter ⚠
- p.Asn373Ser Single submitter ⚠
- p.Asn39Asp Single submitter ⚠
- p.Asn681Asp Single submitter ⚠
- p.Asp182His Single submitter ⚠
- p.Asp200Glu Single submitter ⚠
- p.Asp241Gly Single submitter ⚠
- p.Asp406Asn Single submitter ⚠
- p.Asp568Gly Single submitter ⚠
- p.Asp576Val Single submitter ⚠
- p.Cys295Tyr Single submitter ⚠
- p.Cys337Tyr Single submitter ⚠
- p.Cys344Tyr Single submitter ⚠
- p.Cys362Tyr Single submitter ⚠
- p.Cys378Arg Single submitter ⚠
- p.Cys579Ser Single submitter ⚠
- p.Gln321Lys Single submitter ⚠
- p.Gln386Glu Single submitter ⚠
- p.Glu124Ala Single submitter ⚠
- p.Glu215Val Single submitter ⚠
- p.Glu237Ala Single submitter ⚠
- p.Glu309Lys Single submitter ⚠
- p.Glu45Gly Single submitter ⚠
- p.Glu666Gln Single submitter ⚠
- p.Glu721Lys Single submitter ⚠
- p.Gly129Val Single submitter ⚠
- p.Gly20Asp Single submitter ⚠
- p.Gly287Arg Single submitter ⚠
- p.Gly397Asp Single submitter ⚠
- p.Gly401Arg Single submitter ⚠
- p.Gly429Arg Single submitter ⚠
- p.Gly567Ser Single submitter ⚠
- p.His191Pro Single submitter ⚠
- p.His271Leu Single submitter ⚠
- p.His455Tyr Single submitter ⚠
- p.His633Pro Single submitter ⚠
- p.His633Tyr Single submitter ⚠
- p.Ile120Val Single submitter ⚠
- p.Ile208Thr Single submitter ⚠
- p.Ile329Met Single submitter ⚠
- p.Ile49Met Single submitter ⚠
- p.Ile618Leu Single submitter ⚠
- p.Ile662Thr Single submitter ⚠
- p.Ile662Val Single submitter ⚠
- p.Ile689Val Single submitter ⚠
- p.Leu188Ile Single submitter ⚠
- p.Leu198Ser Single submitter ⚠
- p.Leu276Ile Single submitter ⚠
- p.Leu325Arg Single submitter ⚠
- p.Leu481Phe Single submitter ⚠
- p.Leu552Phe Single submitter ⚠
- p.Leu586Met Single submitter ⚠
- p.Leu7Pro Single submitter ⚠
- p.Lys377Thr Single submitter ⚠
- p.Lys597Glu Single submitter ⚠
- p.Lys65Thr Single submitter ⚠
- p.Lys775Ile Single submitter ⚠
- p.Met385Ile Single submitter ⚠
- p.Met385Thr Single submitter ⚠
- p.Phe359Tyr Single submitter ⚠
- p.Phe541Leu Single submitter ⚠
- p.Pro291Leu Single submitter ⚠
- p.Pro348Leu Single submitter ⚠
- p.Pro392Ala Single submitter ⚠
- p.Pro452Leu Single submitter ⚠
- p.Pro514Leu Single submitter ⚠
- p.Pro593Leu Single submitter ⚠
- p.Pro651Gln Single submitter ⚠
- p.Ser115Pro Single submitter ⚠
- p.Ser160Gly Single submitter ⚠
- p.Ser353Ala Single submitter ⚠
- p.Ser50Cys Single submitter ⚠
- p.Ser525Leu Single submitter ⚠
- p.Ser577Tyr Single submitter ⚠
- p.Thr210Arg Single submitter ⚠
- p.Thr358Ile Single submitter ⚠
- p.Thr358Ser Single submitter ⚠
- p.Thr409Ile Single submitter ⚠
- p.Thr589Arg Single submitter ⚠
- p.Thr743Ala Single submitter ⚠
- p.Thr758Ile Single submitter ⚠
- p.Trp261Cys Single submitter ⚠
- p.Tyr199Cys Single submitter ⚠
- p.Tyr285His Single submitter ⚠
- p.Tyr306Asn Single submitter ⚠
- p.Val193Ala Single submitter ⚠
- p.Val194Met Single submitter ⚠
- p.Val448Ile Single submitter ⚠
- p.Val448Phe Single submitter ⚠
- p.Val574Ile Single submitter ⚠