ADAT1 — 87 ClinVar variants
All ClinVar germline ADAT1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 81 flagged for review →
6 Likely benign · 81 Uncertain significance
Full ADAT1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 81
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 48
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADAT1 p.Ala204Thr Uncertain significance Single submitter
- ADAT1 p.Ala241Gly Uncertain significance Single submitter
- ADAT1 p.Ala268Pro Uncertain significance Single submitter
- ADAT1 p.Ala276Ser Uncertain significance Single submitter
- ADAT1 p.Ala276Val Uncertain significance Single submitter
- ADAT1 p.Ala344Val Uncertain significance Single submitter
- ADAT1 p.Ala379Glu Uncertain significance Single submitter
- ADAT1 p.Ala379Val Uncertain significance Single submitter
- ADAT1 p.Ala44Gly Uncertain significance Single submitter
- ADAT1 p.Ala92Pro Uncertain significance Single submitter
- ADAT1 p.Arg484Gln Uncertain significance Single submitter
- ADAT1 p.Asp144Gly Uncertain significance Single submitter
- ADAT1 p.Asp464Gly Uncertain significance Single submitter
- ADAT1 p.Asp49Asn Uncertain significance Single submitter
- ADAT1 p.Asp52His Uncertain significance Single submitter
- ADAT1 p.Gln216Leu Uncertain significance Single submitter
- ADAT1 p.Gln342His Uncertain significance Single submitter
- ADAT1 p.Gln350Glu Uncertain significance Single submitter
- ADAT1 p.Glu207Asp Uncertain significance Single submitter
- ADAT1 p.Glu405Gln Uncertain significance Single submitter
- ADAT1 p.Gly211Glu Uncertain significance Single submitter
- ADAT1 p.Gly269Glu Uncertain significance Single submitter
- ADAT1 p.Gly310Arg Uncertain significance Single submitter
- ADAT1 p.Gly489Arg Uncertain significance Single submitter
- ADAT1 p.His29Asn Uncertain significance Single submitter
- ADAT1 p.His87Tyr Uncertain significance Single submitter
- ADAT1 p.Ile366Val Uncertain significance Single submitter
- ADAT1 p.Ile424Val Uncertain significance Single submitter
- ADAT1 p.Ile449Thr Uncertain significance Single submitter
- ADAT1 p.Leu309Phe Uncertain significance Single submitter
- ADAT1 p.Lys185Gln Uncertain significance Single submitter
- ADAT1 p.Lys273Glu Uncertain significance Single submitter
- ADAT1 p.Lys53Glu Uncertain significance Single submitter
- ADAT1 p.Met197Ile Uncertain significance Single submitter
- ADAT1 p.Pro157Arg Uncertain significance Single submitter
- ADAT1 p.Pro192Ser Uncertain significance Single submitter
- ADAT1 p.Pro228Leu Uncertain significance Single submitter
- ADAT1 p.Pro496Arg Uncertain significance Single submitter
- ADAT1 p.Pro51Ala Uncertain significance Single submitter
- ADAT1 p.Ser175Arg Uncertain significance Single submitter
- ADAT1 p.Ser296Phe Uncertain significance Single submitter
- ADAT1 p.Ser401Arg Uncertain significance Single submitter
- ADAT1 p.Thr411Ile Uncertain significance Single submitter
- ADAT1 p.Thr50Asn Uncertain significance Single submitter
- ADAT1 p.Thr58Arg Uncertain significance Single submitter
- ADAT1 p.Val380Leu Uncertain significance Single submitter
- ADAT1 p.Val410Ile Uncertain significance Single submitter
-
ADAT1 p.Pro225Arg
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 33
The independent predictors disagree with each other — read with care.
- ADAT1 p.Ala412Thr Uncertain significance Single submitter
- ADAT1 p.Ala473Val Uncertain significance Single submitter
- ADAT1 p.Arg305Gln Uncertain significance Single submitter
- ADAT1 p.Arg451Gly Uncertain significance Single submitter
- ADAT1 p.Arg77Gly Uncertain significance Single submitter
- ADAT1 p.Asp292Gly Uncertain significance Single submitter
- ADAT1 p.Asp5Asn Uncertain significance Single submitter
- ADAT1 p.Gln417Arg Uncertain significance Single submitter
- ADAT1 p.Glu207Lys Uncertain significance Single submitter
- ADAT1 p.Glu322Asp Uncertain significance Single submitter
- ADAT1 p.Gly123Arg Uncertain significance Single submitter
- ADAT1 p.Ile115Val Uncertain significance Single submitter
- ADAT1 p.Ile398Val Uncertain significance Single submitter
- ADAT1 p.Ile71Thr Uncertain significance Single submitter
- ADAT1 p.Leu104Phe Uncertain significance Single submitter
- ADAT1 p.Leu131Phe Uncertain significance Single submitter
- ADAT1 p.Leu33Phe Uncertain significance Single submitter
- ADAT1 p.Leu355Phe Uncertain significance Single submitter
- ADAT1 p.Leu391Phe Uncertain significance Single submitter
- ADAT1 p.Leu483Phe Uncertain significance Single submitter
- ADAT1 p.Lys421Arg Uncertain significance Single submitter
- ADAT1 p.Lys59Glu Uncertain significance Single submitter
- ADAT1 p.Pro160Leu Uncertain significance Single submitter
- ADAT1 p.Pro248His Uncertain significance Single submitter
- ADAT1 p.Pro274Leu Uncertain significance Single submitter
- ADAT1 p.Pro356Ala Uncertain significance Single submitter
- ADAT1 p.Ser296Thr Uncertain significance Single submitter
- ADAT1 p.Ser457Phe Uncertain significance Single submitter
- ADAT1 p.Tyr12Cys Uncertain significance Single submitter
- ADAT1 p.Tyr15Cys Uncertain significance Single submitter
- ADAT1 p.Val193Ile Uncertain significance Single submitter
- ADAT1 p.Val256Leu Uncertain significance Single submitter
- ADAT1 p.Val380Met Uncertain significance Single submitter
All ADAT1 variants
Likely benign 6
- p.Asn168Ser Single submitter
- p.Gly272Arg Single submitter
- p.His231= Single submitter
- p.His29Arg Single submitter
- p.Leu319Phe Single submitter
- p.Pro54= Single submitter
Uncertain significance 81
- p.Ala204Thr Single submitter ⚠
- p.Ala241Gly Single submitter ⚠
- p.Ala268Pro Single submitter ⚠
- p.Ala276Ser Single submitter ⚠
- p.Ala276Val Single submitter ⚠
- p.Ala344Val Single submitter ⚠
- p.Ala379Glu Single submitter ⚠
- p.Ala379Val Single submitter ⚠
- p.Ala412Thr Single submitter ⚠
- p.Ala44Gly Single submitter ⚠
- p.Ala473Val Single submitter ⚠
- p.Ala92Pro Single submitter ⚠
- p.Arg305Gln Single submitter ⚠
- p.Arg451Gly Single submitter ⚠
- p.Arg484Gln Single submitter ⚠
- p.Arg77Gly Single submitter ⚠
- p.Asp144Gly Single submitter ⚠
- p.Asp292Gly Single submitter ⚠
- p.Asp464Gly Single submitter ⚠
- p.Asp49Asn Single submitter ⚠
- p.Asp52His Single submitter ⚠
- p.Asp5Asn Single submitter ⚠
- p.Gln216Leu Single submitter ⚠
- p.Gln342His Single submitter ⚠
- p.Gln350Glu Single submitter ⚠
- p.Gln417Arg Single submitter ⚠
- p.Glu207Asp Single submitter ⚠
- p.Glu207Lys Single submitter ⚠
- p.Glu322Asp Single submitter ⚠
- p.Glu405Gln Single submitter ⚠
- p.Gly123Arg Single submitter ⚠
- p.Gly211Glu Single submitter ⚠
- p.Gly269Glu Single submitter ⚠
- p.Gly310Arg Single submitter ⚠
- p.Gly489Arg Single submitter ⚠
- p.His29Asn Single submitter ⚠
- p.His87Tyr Single submitter ⚠
- p.Ile115Val Single submitter ⚠
- p.Ile366Val Single submitter ⚠
- p.Ile398Val Single submitter ⚠
- p.Ile424Val Single submitter ⚠
- p.Ile449Thr Single submitter ⚠
- p.Ile71Thr Single submitter ⚠
- p.Leu104Phe Single submitter ⚠
- p.Leu131Phe Single submitter ⚠
- p.Leu309Phe Single submitter ⚠
- p.Leu33Phe Single submitter ⚠
- p.Leu355Phe Single submitter ⚠
- p.Leu391Phe Single submitter ⚠
- p.Leu483Phe Single submitter ⚠
- p.Lys185Gln Single submitter ⚠
- p.Lys273Glu Single submitter ⚠
- p.Lys421Arg Single submitter ⚠
- p.Lys53Glu Single submitter ⚠
- p.Lys59Glu Single submitter ⚠
- p.Met197Ile Single submitter ⚠
- p.Pro157Arg Single submitter ⚠
- p.Pro160Leu Single submitter ⚠
- p.Pro192Ser Single submitter ⚠
- p.Pro228Leu Single submitter ⚠
- p.Pro248His Single submitter ⚠
- p.Pro274Leu Single submitter ⚠
- p.Pro356Ala Single submitter ⚠
- p.Pro496Arg Single submitter ⚠
- p.Pro51Ala Single submitter ⚠
- p.Ser175Arg Single submitter ⚠
- p.Ser296Phe Single submitter ⚠
- p.Ser296Thr Single submitter ⚠
- p.Ser401Arg Single submitter ⚠
- p.Ser457Phe Single submitter ⚠
- p.Thr411Ile Single submitter ⚠
- p.Thr50Asn Single submitter ⚠
- p.Thr58Arg Single submitter ⚠
- p.Tyr12Cys Single submitter ⚠
- p.Tyr15Cys Single submitter ⚠
- p.Val193Ile Single submitter ⚠
- p.Val256Leu Single submitter ⚠
- p.Val380Leu Single submitter ⚠
- p.Val380Met Single submitter ⚠
- p.Val410Ile Single submitter ⚠
- p.Pro225Arg No assertion criteria prostate cancer ⚠