ADCYAP1R1 — 50 ClinVar variants
All ClinVar germline ADCYAP1R1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
2 Benign · 3 Likely benign · 45 Uncertain significance
Full ADCYAP1R1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADCYAP1R1 p.Arg116Gln Uncertain significance Single submitter
- ADCYAP1R1 p.Arg353Gln Uncertain significance Single submitter
- ADCYAP1R1 p.Arg413Gly Uncertain significance Single submitter
- ADCYAP1R1 p.Asn186Asp Uncertain significance Single submitter
- ADCYAP1R1 p.Asn186Ser Uncertain significance Single submitter
- ADCYAP1R1 p.Gln214Arg Uncertain significance Single submitter
- ADCYAP1R1 p.Gln455His Uncertain significance Single submitter
- ADCYAP1R1 p.Gly405Val Uncertain significance Single submitter
- ADCYAP1R1 p.His129Gln Uncertain significance Single submitter
- ADCYAP1R1 p.His432Arg Uncertain significance Single submitter
- ADCYAP1R1 p.His432Gln Uncertain significance Single submitter
- ADCYAP1R1 p.Leu435Val Uncertain significance Single submitter
- ADCYAP1R1 p.Leu461Ile Uncertain significance Single submitter
- ADCYAP1R1 p.Leu74Arg Uncertain significance Single submitter
- ADCYAP1R1 p.Met190Ile Uncertain significance Single submitter
- ADCYAP1R1 p.Met190Thr Uncertain significance Single submitter
- ADCYAP1R1 p.Met299Leu Uncertain significance Single submitter
- ADCYAP1R1 p.Met340Val Uncertain significance Single submitter
- ADCYAP1R1 p.Met57Thr Uncertain significance Single submitter
- ADCYAP1R1 p.Phe178Cys Uncertain significance Single submitter
- ADCYAP1R1 p.Phe402Ile Uncertain significance Single submitter
- ADCYAP1R1 p.Pro433Ala Uncertain significance Single submitter
- ADCYAP1R1 p.Ser124Leu Uncertain significance Single submitter
- ADCYAP1R1 p.Ser98Thr Uncertain significance Single submitter
- ADCYAP1R1 p.Thr143Ala Uncertain significance Single submitter
- ADCYAP1R1 p.Thr282Ile Uncertain significance Single submitter
- ADCYAP1R1 p.Tyr148Asp Uncertain significance Single submitter
- ADCYAP1R1 p.Val383Met Uncertain significance Single submitter
- ADCYAP1R1 p.Val398Ile Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- ADCYAP1R1 p.Ala409Val Uncertain significance Single submitter
- ADCYAP1R1 p.Arg177Cys Uncertain significance Single submitter
- ADCYAP1R1 p.Arg431Gln Uncertain significance Single submitter
- ADCYAP1R1 p.Asn48Ser Uncertain significance Single submitter
- ADCYAP1R1 p.Asn60Ser Uncertain significance Single submitter
- ADCYAP1R1 p.Glu344Lys Uncertain significance Single submitter
- ADCYAP1R1 p.His432Tyr Uncertain significance Single submitter
- ADCYAP1R1 p.Ile174Val Uncertain significance Single submitter
- ADCYAP1R1 p.Leu335Ile Uncertain significance Single submitter
- ADCYAP1R1 p.Pro433Leu Uncertain significance Single submitter
- ADCYAP1R1 p.Ser50Phe Uncertain significance Single submitter
- ADCYAP1R1 p.Thr184Pro Uncertain significance Single submitter
- ADCYAP1R1 p.Thr253Ala Uncertain significance Single submitter
- ADCYAP1R1 p.Thr286Met Uncertain significance Single submitter
- ADCYAP1R1 p.Val329Phe Uncertain significance Single submitter
All ADCYAP1R1 variants
Likely benign 3
- p.Ala425Thr Single submitter
- p.Gln88Arg Single submitter
- p.Val426Met Single submitter
Uncertain significance 45
- c.1047-3076C>T Single submitter
- p.Ala409Val Single submitter ⚠
- p.Arg116Gln Single submitter ⚠
- p.Arg177Cys Single submitter ⚠
- p.Arg353Gln Single submitter ⚠
- p.Arg413Gly Single submitter ⚠
- p.Arg431Gln Single submitter ⚠
- p.Asn186Asp Single submitter ⚠
- p.Asn186Ser Single submitter ⚠
- p.Asn48Ser Single submitter ⚠
- p.Asn60Ser Single submitter ⚠
- p.Gln214Arg Single submitter ⚠
- p.Gln455His Single submitter ⚠
- p.Glu344Lys Single submitter ⚠
- p.Gly405Val Single submitter ⚠
- p.His129Gln Single submitter ⚠
- p.His432Arg Single submitter ⚠
- p.His432Gln Single submitter ⚠
- p.His432Tyr Single submitter ⚠
- p.Ile174Val Single submitter ⚠
- p.Leu335Ile Single submitter ⚠
- p.Leu435Val Single submitter ⚠
- p.Leu461Ile Single submitter ⚠
- p.Leu74Arg Single submitter ⚠
- p.Met190Ile Single submitter ⚠
- p.Met190Thr Single submitter ⚠
- p.Met299Leu Single submitter ⚠
- p.Met340Val Single submitter ⚠
- p.Met57Thr Single submitter ⚠
- p.Phe178Cys Single submitter ⚠
- p.Phe402Ile Single submitter ⚠
- p.Pro433Ala Single submitter ⚠
- p.Pro433Leu Single submitter ⚠
- p.Ser124Leu Single submitter ⚠
- p.Ser50Phe Single submitter ⚠
- p.Ser98Thr Single submitter ⚠
- p.Thr143Ala Single submitter ⚠
- p.Thr184Pro Single submitter ⚠
- p.Thr253Ala Single submitter ⚠
- p.Thr282Ile Single submitter ⚠
- p.Thr286Met Single submitter ⚠
- p.Tyr148Asp Single submitter ⚠
- p.Val329Phe Single submitter ⚠
- p.Val383Met Single submitter ⚠
- p.Val398Ile Single submitter ⚠