ADGRD1 — 98 ClinVar variants
All ClinVar germline ADGRD1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 87 flagged for review →
11 Likely benign · 87 Uncertain significance
Full ADGRD1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 87
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 55
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADGRD1 p.Pro165Ala Uncertain significance Multiple submitters
- ADGRD1 p.Ala124Thr Uncertain significance Single submitter
- ADGRD1 p.Ala124Val Uncertain significance Single submitter
- ADGRD1 p.Ala565Val Uncertain significance Single submitter
- ADGRD1 p.Arg150Gln Uncertain significance Single submitter
- ADGRD1 p.Arg505Gln Uncertain significance Single submitter
- ADGRD1 p.Asn437Ser Uncertain significance Single submitter
- ADGRD1 p.Asp744Asn Uncertain significance Single submitter
- ADGRD1 p.Cys100Arg Uncertain significance Single submitter
- ADGRD1 p.Cys454Trp Uncertain significance Single submitter
- ADGRD1 p.Cys783Phe Uncertain significance Single submitter
- ADGRD1 p.Gln214Arg Uncertain significance Single submitter
- ADGRD1 p.Gln291Arg Uncertain significance Single submitter
- ADGRD1 p.Gln740His Uncertain significance Single submitter
- ADGRD1 p.Glu203Asp Uncertain significance Single submitter
- ADGRD1 p.Gly101Ser Uncertain significance Single submitter
- ADGRD1 p.Gly115Arg Uncertain significance Single submitter
- ADGRD1 p.Gly141Ser Uncertain significance Single submitter
- ADGRD1 p.Gly186Arg Uncertain significance Single submitter
- ADGRD1 p.Gly425Ser Uncertain significance Single submitter
- ADGRD1 p.Gly654Ala Uncertain significance Single submitter
- ADGRD1 p.Gly782Ser Uncertain significance Single submitter
- ADGRD1 p.Gly850Asp Uncertain significance Single submitter
- ADGRD1 p.Gly87Ser Uncertain significance Single submitter
- ADGRD1 p.His416Arg Uncertain significance Single submitter
- ADGRD1 p.His640Gln Uncertain significance Single submitter
- ADGRD1 p.Ile280Leu Uncertain significance Single submitter
- ADGRD1 p.Ile569Asn Uncertain significance Single submitter
- ADGRD1 p.Ile688Leu Uncertain significance Single submitter
- ADGRD1 p.Leu794Pro Uncertain significance Single submitter
- ADGRD1 p.Lys861Asn Uncertain significance Single submitter
- ADGRD1 p.Met650Ile Uncertain significance Single submitter
- ADGRD1 p.Met695Val Uncertain significance Single submitter
- ADGRD1 p.Met844Ile Uncertain significance Single submitter
- ADGRD1 p.Phe324Ser Uncertain significance Single submitter
- ADGRD1 p.Pro370Leu Uncertain significance Single submitter
- ADGRD1 p.Pro849Gln Uncertain significance Single submitter
- ADGRD1 p.Ser153Thr Uncertain significance Single submitter
- ADGRD1 p.Ser344Gly Uncertain significance Single submitter
- ADGRD1 p.Ser497Arg Uncertain significance Single submitter
- ADGRD1 p.Ser577Phe Uncertain significance Single submitter
- ADGRD1 p.Ser753Asn Uncertain significance Single submitter
- ADGRD1 p.Thr173Ile Uncertain significance Single submitter
- ADGRD1 p.Thr530Met Uncertain significance Single submitter
- ADGRD1 p.Thr545Ala Uncertain significance Single submitter
- ADGRD1 p.Thr833Ala Uncertain significance Single submitter
- ADGRD1 p.Thr854Ala Uncertain significance Single submitter
- ADGRD1 p.Trp13Cys Uncertain significance Single submitter
- ADGRD1 p.Trp156Cys Uncertain significance Single submitter
- ADGRD1 p.Tyr602His Uncertain significance Single submitter
- ADGRD1 p.Tyr746Cys Uncertain significance Single submitter
- ADGRD1 p.Val206Ile Uncertain significance Single submitter
- ADGRD1 p.Val590Met Uncertain significance Single submitter
- ADGRD1 p.Val612Met Uncertain significance Single submitter
- ADGRD1 p.Val823Leu Uncertain significance Single submitter
Predictors split 32
The independent predictors disagree with each other — read with care.
- ADGRD1 p.Ala381Ser Uncertain significance Single submitter
- ADGRD1 p.Ala40Val Uncertain significance Single submitter
- ADGRD1 p.Ala648Val Uncertain significance Single submitter
- ADGRD1 p.Ala709Val Uncertain significance Single submitter
- ADGRD1 p.Arg399His Uncertain significance Single submitter
- ADGRD1 p.Arg493Cys Uncertain significance Single submitter
- ADGRD1 p.Arg832His Uncertain significance Single submitter
- ADGRD1 p.Gly336Val Uncertain significance Single submitter
- ADGRD1 p.Gly404Arg Uncertain significance Single submitter
- ADGRD1 p.Gly729Asp Uncertain significance Single submitter
- ADGRD1 p.His450Tyr Uncertain significance Single submitter
- ADGRD1 p.Ile280Val Uncertain significance Single submitter
- ADGRD1 p.Leu529Pro Uncertain significance Single submitter
- ADGRD1 p.Leu550Ile Uncertain significance Single submitter
- ADGRD1 p.Phe642Leu Uncertain significance Single submitter
- ADGRD1 p.Pro237Leu Uncertain significance Single submitter
- ADGRD1 p.Pro469Gln Uncertain significance Single submitter
- ADGRD1 p.Ser268Gly Uncertain significance Single submitter
- ADGRD1 p.Ser313Leu Uncertain significance Single submitter
- ADGRD1 p.Ser363Phe Uncertain significance Single submitter
- ADGRD1 p.Ser595Asn Uncertain significance Single submitter
- ADGRD1 p.Ser622Asn Uncertain significance Single submitter
- ADGRD1 p.Ser841Leu Uncertain significance Single submitter
- ADGRD1 p.Thr535Ile Uncertain significance Single submitter
- ADGRD1 p.Thr758Ile Uncertain significance Single submitter
- ADGRD1 p.Tyr509Cys Uncertain significance Single submitter
- ADGRD1 p.Tyr676Cys Uncertain significance Single submitter
- ADGRD1 p.Val374Met Likely benign Single submitter
- ADGRD1 p.Val564Gly Uncertain significance Single submitter
- ADGRD1 p.Val578Met Uncertain significance Single submitter
- ADGRD1 p.Val637Met Uncertain significance Single submitter
- ADGRD1 p.Val777Met Uncertain significance Single submitter
All ADGRD1 variants
Likely benign 11
- p.Ala528Val Single submitter
- p.Ala836= Single submitter
- p.Arg624His Single submitter
- p.Ile338Thr Single submitter
- p.Ile354Val Single submitter
- p.Ile388Leu Single submitter
- p.Lys444= Single submitter
- p.Lys756= Single submitter
- p.Ser198= Single submitter
- p.Val346Met Single submitter
- p.Val374Met Single submitter ⚠
Uncertain significance 87
- p.Pro165Ala Multiple submitters ⚠
- p.Ala124Thr Single submitter ⚠
- p.Ala124Val Single submitter ⚠
- p.Ala381Ser Single submitter ⚠
- p.Ala40Val Single submitter ⚠
- p.Ala565Val Single submitter ⚠
- p.Ala648Val Single submitter ⚠
- p.Ala709Val Single submitter ⚠
- p.Arg150Gln Single submitter ⚠
- p.Arg399His Single submitter ⚠
- p.Arg493Cys Single submitter ⚠
- p.Arg505Gln Single submitter ⚠
- p.Arg832His Single submitter ⚠
- p.Asn437Ser Single submitter ⚠
- p.Asp744Asn Single submitter ⚠
- p.Cys100Arg Single submitter ⚠
- p.Cys454Trp Single submitter ⚠
- p.Cys783Phe Single submitter ⚠
- p.Gln214Arg Single submitter ⚠
- p.Gln291Arg Single submitter ⚠
- p.Gln740His Single submitter ⚠
- p.Glu203Asp Single submitter ⚠
- p.Gly101Ser Single submitter ⚠
- p.Gly115Arg Single submitter ⚠
- p.Gly141Ser Single submitter ⚠
- p.Gly186Arg Single submitter ⚠
- p.Gly336Val Single submitter ⚠
- p.Gly404Arg Single submitter ⚠
- p.Gly425Ser Single submitter ⚠
- p.Gly654Ala Single submitter ⚠
- p.Gly729Asp Single submitter ⚠
- p.Gly782Ser Single submitter ⚠
- p.Gly850Asp Single submitter ⚠
- p.Gly87Ser Single submitter ⚠
- p.His416Arg Single submitter ⚠
- p.His450Tyr Single submitter ⚠
- p.His640Gln Single submitter ⚠
- p.Ile280Leu Single submitter ⚠
- p.Ile280Val Single submitter ⚠
- p.Ile549= Single submitter
- p.Ile569Asn Single submitter ⚠
- p.Ile688Leu Single submitter ⚠
- p.Leu529Pro Single submitter ⚠
- p.Leu550Ile Single submitter ⚠
- p.Leu794Pro Single submitter ⚠
- p.Lys861Asn Single submitter ⚠
- p.Met650Ile Single submitter ⚠
- p.Met695Val Single submitter ⚠
- p.Met844Ile Single submitter ⚠
- p.Phe324Ser Single submitter ⚠
- p.Phe642Leu Single submitter ⚠
- p.Pro237Leu Single submitter ⚠
- p.Pro370Leu Single submitter ⚠
- p.Pro469Gln Single submitter ⚠
- p.Pro849Gln Single submitter ⚠
- p.Ser153Thr Single submitter ⚠
- p.Ser268Gly Single submitter ⚠
- p.Ser313Leu Single submitter ⚠
- p.Ser344Gly Single submitter ⚠
- p.Ser363Phe Single submitter ⚠
- p.Ser497Arg Single submitter ⚠
- p.Ser577Phe Single submitter ⚠
- p.Ser595Asn Single submitter ⚠
- p.Ser622Asn Single submitter ⚠
- p.Ser753Asn Single submitter ⚠
- p.Ser841Leu Single submitter ⚠
- p.Thr173Ile Single submitter ⚠
- p.Thr530Met Single submitter ⚠
- p.Thr535Ile Single submitter ⚠
- p.Thr545Ala Single submitter ⚠
- p.Thr758Ile Single submitter ⚠
- p.Thr833Ala Single submitter ⚠
- p.Thr854Ala Single submitter ⚠
- p.Trp13Cys Single submitter ⚠
- p.Trp156Cys Single submitter ⚠
- p.Tyr509Cys Single submitter ⚠
- p.Tyr602His Single submitter ⚠
- p.Tyr676Cys Single submitter ⚠
- p.Tyr746Cys Single submitter ⚠
- p.Val206Ile Single submitter ⚠
- p.Val564Gly Single submitter ⚠
- p.Val578Met Single submitter ⚠
- p.Val590Met Single submitter ⚠
- p.Val612Met Single submitter ⚠
- p.Val637Met Single submitter ⚠
- p.Val777Met Single submitter ⚠
- p.Val823Leu Single submitter ⚠