ADGRG5 — 92 ClinVar variants

All ClinVar germline ADGRG5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 84 flagged for review →

2 Benign · 8 Likely benign · 82 Uncertain significance

Full ADGRG5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 84

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 42

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 42

The independent predictors disagree with each other — read with care.

All ADGRG5 variants

Benign 2

p.Thr20Ala Multiple submitters
p.Leu300Val Single submitter ⚠

Likely benign 8

p.Arg119Gln Single submitter
p.Arg210His Single submitter
p.Arg509His Single submitter ⚠
p.Asn166Ser Single submitter
p.Asp390Asn Single submitter
p.Gly397Ala Single submitter
p.His454Arg Single submitter
p.Val479Ile Single submitter

Uncertain significance 82

p.Cys453Arg Multiple submitters ⚠
p.Ala115Thr Single submitter ⚠
p.Ala303Thr Single submitter ⚠
p.Ala305Pro Single submitter ⚠
p.Ala319Thr Single submitter ⚠
p.Ala324Thr Single submitter ⚠
p.Ala447Val Single submitter ⚠
p.Ala473Val Single submitter ⚠
p.Ala514Asp Single submitter ⚠
p.Ala77Thr Single submitter ⚠
p.Arg106Trp Single submitter ⚠
p.Arg125His Single submitter ⚠
p.Arg130Trp Single submitter ⚠
p.Arg210Cys Single submitter ⚠
p.Arg210Gly Single submitter ⚠
p.Arg222His Single submitter ⚠
p.Arg407Trp Single submitter ⚠
p.Arg439Cys Single submitter ⚠
p.Arg440Gly Single submitter ⚠
p.Arg442Trp Single submitter ⚠
p.Arg444Gln Single submitter ⚠
p.Asn146Asp Single submitter ⚠
p.Asn18Thr Single submitter ⚠
p.Asn348Asp Single submitter ⚠
p.Asn427Asp Single submitter ⚠
p.Asp144Gly Single submitter ⚠
p.Cys209Gly Single submitter ⚠
p.Cys4Trp Single submitter ⚠
p.Gln48Arg Single submitter ⚠
p.Gln506His Single submitter ⚠
p.Glu116Lys Single submitter ⚠
p.Gly202Arg Single submitter ⚠
p.Gly202Trp Single submitter ⚠
p.Gly203Arg Single submitter ⚠
p.Gly203Ser Single submitter ⚠
p.Gly364Ala Single submitter ⚠
p.Gly420Ser Single submitter ⚠
p.Gly421Ser Single submitter ⚠
p.His164Gln Single submitter ⚠
p.His412Arg Single submitter ⚠
p.Ile132Thr Single submitter ⚠
p.Ile134Thr Single submitter ⚠
p.Leu16Val Single submitter ⚠
p.Leu182Arg Single submitter ⚠
p.Leu244Val Single submitter ⚠
p.Leu371Arg Single submitter ⚠
p.Leu76Met Single submitter ⚠
p.Leu94Met Single submitter ⚠
p.Met34Thr Single submitter ⚠
p.Met401Ile Single submitter ⚠
p.Phe176Cys Single submitter ⚠
p.Phe474Tyr Single submitter ⚠
p.Pro126Arg Single submitter ⚠
p.Pro126Leu Single submitter ⚠
p.Pro214Ala Single submitter ⚠
p.Pro237Ser Single submitter ⚠
p.Ser236Phe Single submitter ⚠
p.Ser259Cys Single submitter ⚠
p.Ser263Leu Single submitter ⚠
p.Ser379Leu Single submitter ⚠
p.Ser391Asn Single submitter ⚠
p.Ser45Pro Single submitter ⚠
p.Ser510Leu Single submitter ⚠
p.Ser88Leu Single submitter ⚠
p.Thr139Asn Single submitter ⚠
p.Thr249Met Single submitter ⚠
p.Thr281Ile Single submitter ⚠
p.Thr315Met Single submitter ⚠
p.Thr396Ala Single submitter ⚠
p.Thr526Ala Single submitter ⚠
p.Thr72Ile Single submitter ⚠
p.Trp177Arg Single submitter ⚠
p.Trp201Ser Single submitter ⚠
p.Trp502Leu Single submitter ⚠
p.Tyr185His Single submitter ⚠
p.Tyr228Ser Single submitter ⚠
p.Val155Ile Single submitter ⚠
p.Val165Met Single submitter ⚠
p.Val291Met Single submitter ⚠
p.Val406Met Single submitter ⚠
p.Val410Met Single submitter ⚠
p.Val450Ile Single submitter ⚠