ADGRG7 — 135 ClinVar variants

All ClinVar germline ADGRG7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 120 flagged for review →

2 Conflicting · 3 Benign · 1 Benign/Likely benign · 12 Likely benign · 117 Uncertain significance

Full ADGRG7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 120

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 2

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 73

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 45

The independent predictors disagree with each other — read with care.

All ADGRG7 variants

Conflicting classifications of pathogenicity 2

p.His770Arg Single submitter ⚠
p.Thr768Asn Single submitter ⚠

Benign 3

p.Arg756His Multiple submitters
p.Gln598= Multiple submitters
p.Val11= Multiple submitters

Benign/Likely benign 1

p.Ala731Thr Multiple submitters

Likely benign 12

c.839-7C>T Single submitter
p.Arg411His Single submitter
p.Arg460= Single submitter
p.Arg564Gln Single submitter ⚠
p.Arg772His Single submitter ⚠
p.Ile205Val Single submitter
p.Ile292Val Single submitter
p.Ile454Val Single submitter
p.Ile64Val Single submitter
p.Pro753Leu Single submitter
p.Pro780Leu Single submitter
p.Thr768Ala Single submitter

Uncertain significance 117

p.Ala112Val Single submitter ⚠
p.Ala443Thr Single submitter ⚠
p.Ala450Thr Single submitter ⚠
p.Ala545Ser Single submitter ⚠
p.Ala548Ser Single submitter ⚠
p.Ala548Thr Single submitter ⚠
p.Ala583Ser Single submitter ⚠
p.Arg10Trp Single submitter ⚠
p.Arg119Gln Single submitter ⚠
p.Arg119Trp Single submitter ⚠
p.Arg274Cys Single submitter ⚠
p.Arg409Cys Single submitter ⚠
p.Arg557Thr Single submitter ⚠
p.Arg5Cys Single submitter ⚠
p.Arg5His Single submitter ⚠
p.Arg604Gln Single submitter ⚠
p.Arg604Trp Single submitter ⚠
p.Arg744Ser Single submitter ⚠
p.Arg752Trp Single submitter ⚠
p.Arg754Ser Single submitter ⚠
p.Arg764Ser Single submitter ⚠
p.Arg772Cys Single submitter ⚠
p.Asn140Thr Single submitter ⚠
p.Asn159Lys Single submitter ⚠
p.Asn191Ser Single submitter ⚠
p.Asn272Tyr Single submitter ⚠
p.Asn417Ser Single submitter ⚠
p.Asn417Thr Single submitter ⚠
p.Asn439Ser Single submitter ⚠
p.Asn510Ser Single submitter ⚠
p.Asp108Val Single submitter ⚠
p.Asp228Tyr Single submitter ⚠
p.Asp394His Single submitter ⚠
p.Asp427Gly Single submitter ⚠
p.Asp502Asn Single submitter ⚠
p.Cys442Ser Single submitter ⚠
p.Gln103Lys Single submitter ⚠
p.Gln237Lys Single submitter ⚠
p.Gln278Lys Single submitter ⚠
p.Gln345Lys Single submitter ⚠
p.Glu50Asp Single submitter ⚠
p.Glu784Lys Single submitter ⚠
p.Glu81Gly Single submitter ⚠
p.Gly106Ser Single submitter ⚠
p.Gly106Val Single submitter ⚠
p.Gly113Asp Single submitter ⚠
p.Gly22Cys Single submitter ⚠
p.Gly269Arg Single submitter ⚠
p.Gly26Glu Single submitter ⚠
p.Gly397Asp Single submitter ⚠
p.Gly71Arg Single submitter ⚠
p.His293Arg Single submitter ⚠
p.His293Asp Single submitter ⚠
p.Ile129Thr Single submitter ⚠
p.Ile235Thr Single submitter ⚠
p.Ile235Val Single submitter ⚠
p.Ile529Met Single submitter ⚠
p.Ile573Val Single submitter ⚠
p.Ile584Thr Single submitter ⚠
p.Leu211Phe Single submitter ⚠
p.Leu331Val Single submitter ⚠
p.Leu444Pro Single submitter ⚠
p.Leu496Phe Single submitter ⚠
p.Leu572Phe Single submitter ⚠
p.Leu686Pro Single submitter ⚠
p.Lys148Arg Single submitter ⚠
p.Lys151Arg Single submitter ⚠
p.Lys319Asn Single submitter ⚠
p.Lys400Glu Single submitter ⚠
p.Lys402Glu Single submitter ⚠
p.Lys432Gln Single submitter ⚠
p.Met116Thr Single submitter ⚠
p.Met478Val Single submitter ⚠
p.Met525Val Single submitter ⚠
p.Met559Ile Single submitter ⚠
p.Met642Arg Single submitter ⚠
p.Met642Leu Single submitter ⚠
p.Phe262Leu Single submitter ⚠
p.Phe708Leu Single submitter ⚠
p.Phe727Val Single submitter ⚠
p.Phe90Ser Single submitter ⚠
p.Pro369Ser Single submitter ⚠
p.Pro431Leu Single submitter ⚠
p.Pro48Leu Single submitter ⚠
p.Pro616fs Single submitter
p.Pro623Leu Single submitter ⚠
p.Ser341Leu Single submitter ⚠
p.Ser360Arg Single submitter ⚠
p.Ser362Ala Single submitter ⚠
p.Ser389Leu Single submitter ⚠
p.Ser438Thr Single submitter ⚠
p.Ser46Thr Single submitter ⚠
p.Ser638Asn Single submitter ⚠
p.Ser666Pro Single submitter ⚠
p.Ser702Asn Single submitter ⚠
p.Thr175Ala Single submitter ⚠
p.Thr183Met Single submitter ⚠
p.Thr207Arg Single submitter ⚠
p.Thr352Ile Single submitter ⚠
p.Thr49Ala Single submitter ⚠
p.Thr542Pro Single submitter ⚠
p.Thr751Ala Single submitter ⚠
p.Thr786Ile Single submitter ⚠
p.Trp469Gly Single submitter ⚠
p.Trp626Leu Single submitter ⚠
p.Tyr326Cys Single submitter ⚠
p.Tyr379Phe Single submitter ⚠
p.Tyr85Cys Single submitter ⚠
p.Val16Met Single submitter ⚠
p.Val250Leu Single submitter ⚠
p.Val251Leu Single submitter ⚠
p.Val470Ile Single submitter ⚠
p.Val577Phe Single submitter ⚠
p.Val671Asp Single submitter ⚠
p.Val700Phe Single submitter ⚠
p.Val722Leu Single submitter ⚠
p.Val95Leu Single submitter ⚠