ADGRL4 — 102 ClinVar variants

All ClinVar germline ADGRL4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 92 flagged for review →

1 Benign · 4 Likely benign · 97 Uncertain significance

Full ADGRL4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 92

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 76

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 16

The independent predictors disagree with each other — read with care.

All ADGRL4 variants

Benign 1

p.Asn280= Multiple submitters

Likely benign 4

p.Arg367Lys Single submitter
p.Cys115= Single submitter
p.Thr566= Single submitter
p.Val120Ala Single submitter

Uncertain significance 97

p.Ala124Thr Single submitter ⚠
p.Ala141Gly Single submitter ⚠
p.Ala287Ser Single submitter ⚠
p.Ala296Val Single submitter ⚠
p.Arg402His Single submitter ⚠
p.Arg402Ser Single submitter ⚠
p.Asn149Asp Single submitter ⚠
p.Asn294Ser Single submitter ⚠
p.Asn484Ser Single submitter ⚠
p.Asn486Lys Single submitter ⚠
p.Asn681Ser Single submitter ⚠
p.Asn72Lys Single submitter ⚠
p.Asp103Asn Single submitter ⚠
p.Asp118Gly Single submitter ⚠
p.Asp247His Single submitter ⚠
p.Asp290Glu Single submitter ⚠
p.Asp58Val Single submitter ⚠
p.Cys121Ser Single submitter ⚠
p.Cys468Tyr Single submitter ⚠
p.Cys579Trp Single submitter ⚠
p.Cys62Tyr Single submitter ⚠
p.Cys75Phe Single submitter ⚠
p.Gln144Glu Single submitter ⚠
p.Glu230Gly Single submitter ⚠
p.Glu567Lys Single submitter ⚠
p.Glu71Lys Single submitter ⚠
p.Gly382Asp Single submitter ⚠
p.Gly388Asp Single submitter ⚠
p.Gly47Arg Single submitter ⚠
p.Gly47Val Single submitter ⚠
p.Gly495Arg Single submitter ⚠
p.Gly546Glu Single submitter ⚠
p.Gly576Ter Single submitter
p.Gly63Glu Single submitter ⚠
p.Gly657Ala Single submitter ⚠
p.His359Leu Single submitter ⚠
p.His463Tyr Single submitter ⚠
p.Ile108Thr Single submitter ⚠
p.Ile108Val Single submitter ⚠
p.Ile136Met Single submitter ⚠
p.Ile136Thr Single submitter ⚠
p.Ile281Val Single submitter ⚠
p.Ile305Thr Single submitter ⚠
p.Ile332Val Single submitter ⚠
p.Ile336Thr Single submitter ⚠
p.Ile35Leu Single submitter ⚠
p.Ile437Val Single submitter ⚠
p.Ile462Met Single submitter ⚠
p.Ile513Val Single submitter ⚠
p.Ile518Met Single submitter ⚠
p.Ile593Thr Single submitter
p.Ile613Val Single submitter ⚠
p.Ile632Val Single submitter ⚠
p.Leu117Ile Single submitter ⚠
p.Leu213Phe Single submitter ⚠
p.Leu308Phe Single submitter ⚠
p.Leu308Ser Single submitter ⚠
p.Leu587Phe Single submitter ⚠
p.Leu603Met Single submitter ⚠
p.Leu648Val Single submitter ⚠
p.Leu662Phe Single submitter ⚠
p.Leu667Ser Single submitter ⚠
p.Lys487Arg Single submitter ⚠
p.Met340Val Single submitter ⚠
p.Phe477Leu Single submitter ⚠
p.Phe663Leu Single submitter ⚠
p.Phe99Leu Single submitter ⚠
p.Pro345Ser Single submitter ⚠
p.Pro377Thr Single submitter ⚠
p.Pro5Arg Single submitter ⚠
p.Pro605Ser Single submitter
p.Pro683Thr Single submitter ⚠
p.Ser187Pro Single submitter ⚠
p.Ser453Arg Single submitter ⚠
p.Ser457Arg Single submitter ⚠
p.Ser548Leu Single submitter ⚠
p.Ser608Asn Single submitter ⚠
p.Thr131Ala Single submitter ⚠
p.Thr251Met Single submitter ⚠
p.Thr379Asn Single submitter ⚠
p.Trp384Leu Single submitter ⚠
p.Tyr289Cys Single submitter ⚠
p.Tyr301Cys Single submitter ⚠
p.Tyr302Phe Single submitter ⚠
p.Tyr322Cys Single submitter ⚠
p.Tyr348Ser Single submitter
p.Tyr424Cys Single submitter ⚠
p.Tyr516Cys Single submitter ⚠
p.Val151Ala Single submitter ⚠
p.Val195Ala Single submitter ⚠
p.Val195Leu Single submitter ⚠
p.Val295Phe Single submitter ⚠
p.Val522Leu Single submitter ⚠
p.Val545Ile Single submitter
p.Val561Ile Single submitter ⚠
p.Val644Ile Single submitter ⚠
p.Val9Ile Single submitter ⚠