ADNP2 — 180 ClinVar variants
All ClinVar germline ADNP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 163 flagged for review →
19 Likely benign · 161 Uncertain significance
Full ADNP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 163
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 103
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADNP2 p.Ala222Thr Uncertain significance Single submitter
- ADNP2 p.Ala271Val Uncertain significance Single submitter
- ADNP2 p.Ala287Thr Uncertain significance Single submitter
- ADNP2 p.Ala326Pro Uncertain significance Single submitter
- ADNP2 p.Ala511Thr Uncertain significance Single submitter
- ADNP2 p.Ala632Val Uncertain significance Single submitter
- ADNP2 p.Ala635Thr Uncertain significance Single submitter
- ADNP2 p.Ala814Val Uncertain significance Single submitter
- ADNP2 p.Arg1049His Uncertain significance Single submitter
- ADNP2 p.Arg442Gln Uncertain significance Single submitter
- ADNP2 p.Arg837Gln Uncertain significance Single submitter
- ADNP2 p.Asn1022Lys Uncertain significance Single submitter
- ADNP2 p.Asn1126Asp Uncertain significance Single submitter
- ADNP2 p.Asn223Ser Uncertain significance Single submitter
- ADNP2 p.Asn684His Uncertain significance Single submitter
- ADNP2 p.Asn706Ser Uncertain significance Single submitter
- ADNP2 p.Asn958Ser Uncertain significance Single submitter
- ADNP2 p.Asp1003Gly Uncertain significance Single submitter
- ADNP2 p.Asp1003His Uncertain significance Single submitter
- ADNP2 p.Asp202Asn Uncertain significance Single submitter
- ADNP2 p.Gln227Leu Uncertain significance Single submitter
- ADNP2 p.Gln483Arg Uncertain significance Single submitter
- ADNP2 p.Gln483His Uncertain significance Single submitter
- ADNP2 p.Glu1047Lys Uncertain significance Single submitter
- ADNP2 p.Glu207Asp Uncertain significance Single submitter
- ADNP2 p.Glu33Lys Uncertain significance Single submitter
- ADNP2 p.Glu744Gly Uncertain significance Single submitter
- ADNP2 p.Glu760Asp Uncertain significance Single submitter
- ADNP2 p.Glu97Asp Uncertain significance Single submitter
- ADNP2 p.Gly121Glu Uncertain significance Single submitter
- ADNP2 p.Gly341Ala Uncertain significance Single submitter
- ADNP2 p.Gly360Arg Uncertain significance Single submitter
- ADNP2 p.Gly54Val Uncertain significance Single submitter
- ADNP2 p.Gly868Arg Uncertain significance Single submitter
- ADNP2 p.Gly871Asp Uncertain significance Single submitter
- ADNP2 p.Gly983Ser Uncertain significance Single submitter
- ADNP2 p.Gly993Glu Uncertain significance Single submitter
- ADNP2 p.His293Arg Uncertain significance Single submitter
- ADNP2 p.His780Tyr Uncertain significance Single submitter
- ADNP2 p.His848Arg Uncertain significance Single submitter
- ADNP2 p.His93Arg Uncertain significance Single submitter
- ADNP2 p.His984Arg Uncertain significance Single submitter
- ADNP2 p.Ile1030Val Uncertain significance Single submitter
- ADNP2 p.Ile209Thr Uncertain significance Single submitter
- ADNP2 p.Ile209Val Uncertain significance Single submitter
- ADNP2 p.Ile22Val Uncertain significance Single submitter
- ADNP2 p.Ile266Val Uncertain significance Single submitter
- ADNP2 p.Ile509Val Uncertain significance Single submitter
- ADNP2 p.Ile828Val Uncertain significance Single submitter
- ADNP2 p.Ile843Val Uncertain significance Single submitter
- ADNP2 p.Leu142Ser Uncertain significance Single submitter
- ADNP2 p.Leu260His Uncertain significance Single submitter
- ADNP2 p.Leu765Ser Uncertain significance Single submitter
- ADNP2 p.Leu85Phe Uncertain significance Single submitter
- ADNP2 p.Leu892Gln Uncertain significance Single submitter
- ADNP2 p.Lys1010Asn Uncertain significance Single submitter
- ADNP2 p.Lys1010Glu Uncertain significance Single submitter
- ADNP2 p.Lys1044Arg Uncertain significance Single submitter
- ADNP2 p.Lys1103Glu Uncertain significance Single submitter
- ADNP2 p.Lys18Thr Uncertain significance Single submitter
- ADNP2 p.Lys688Thr Uncertain significance Single submitter
- ADNP2 p.Lys858Arg Uncertain significance Single submitter
- ADNP2 p.Lys943Glu Uncertain significance Single submitter
- ADNP2 p.Met331Lys Uncertain significance Single submitter
- ADNP2 p.Met639Ile Uncertain significance Single submitter
- ADNP2 p.Met969Leu Uncertain significance Single submitter
- ADNP2 p.Phe1057Leu Uncertain significance Single submitter
- ADNP2 p.Phe1080Ser Uncertain significance Single submitter
- ADNP2 p.Pro1008Ala Uncertain significance Single submitter
- ADNP2 p.Pro198Leu Uncertain significance Single submitter
- ADNP2 p.Pro268Ser Uncertain significance Single submitter
- ADNP2 p.Pro308Ser Uncertain significance Single submitter
- ADNP2 p.Pro324Ala Uncertain significance Single submitter
- ADNP2 p.Pro324Ser Uncertain significance Single submitter
- ADNP2 p.Pro354Thr Uncertain significance Single submitter
- ADNP2 p.Pro427Ser Uncertain significance Single submitter
- ADNP2 p.Pro628Ser Uncertain significance Single submitter
- ADNP2 p.Pro636Gln Uncertain significance Single submitter
- ADNP2 p.Pro800Leu Uncertain significance Single submitter
- ADNP2 p.Pro854Ala Uncertain significance Single submitter
- ADNP2 p.Pro883Leu Uncertain significance Single submitter
- ADNP2 p.Pro953Ser Uncertain significance Single submitter
- ADNP2 p.Pro997Ser Uncertain significance Single submitter
- ADNP2 p.Ser1078Leu Uncertain significance Single submitter
- ADNP2 p.Ser300Arg Uncertain significance Single submitter
- ADNP2 p.Ser318Gly Uncertain significance Single submitter
- ADNP2 p.Ser52Leu Uncertain significance Single submitter
- ADNP2 p.Ser587Ala Uncertain significance Single submitter
- ADNP2 p.Ser587Leu Uncertain significance Single submitter
- ADNP2 p.Ser62Tyr Uncertain significance Single submitter
- ADNP2 p.Ser869Asn Uncertain significance Single submitter
- ADNP2 p.Ser945Arg Uncertain significance Single submitter
- ADNP2 p.Ser973Gly Uncertain significance Single submitter
- ADNP2 p.Thr1012Arg Uncertain significance Single submitter
- ADNP2 p.Thr1026Ala Uncertain significance Single submitter
- ADNP2 p.Thr478Ile Uncertain significance Single submitter
- ADNP2 p.Thr573Ser Uncertain significance Single submitter
- ADNP2 p.Thr70Arg Uncertain significance Single submitter
- ADNP2 p.Thr866Ile Uncertain significance Single submitter
- ADNP2 p.Tyr137Cys Uncertain significance Single submitter
- ADNP2 p.Tyr856Cys Uncertain significance Single submitter
- ADNP2 p.Tyr95His Uncertain significance Single submitter
- ADNP2 p.Val105Met Uncertain significance Single submitter
Predictors split 60
The independent predictors disagree with each other — read with care.
- ADNP2 p.Ala451Gly Uncertain significance Single submitter
- ADNP2 p.Ala493Ser Uncertain significance Single submitter
- ADNP2 p.Ala530Pro Uncertain significance Single submitter
- ADNP2 p.Ala733Ser Uncertain significance Single submitter
- ADNP2 p.Ala941Val Uncertain significance Single submitter
- ADNP2 p.Arg1094Thr Uncertain significance Single submitter
- ADNP2 p.Arg132Trp Uncertain significance Single submitter
- ADNP2 p.Arg496Trp Uncertain significance Single submitter
- ADNP2 p.Arg937Cys Uncertain significance Single submitter
- ADNP2 p.Arg94His Uncertain significance Single submitter
- ADNP2 p.Asn368Lys Uncertain significance Single submitter
- ADNP2 p.Asn411Lys Uncertain significance Single submitter
- ADNP2 p.Asn90Ile Uncertain significance Single submitter
- ADNP2 p.Asp1033Val Uncertain significance Single submitter
- ADNP2 p.Asp1042His Uncertain significance Single submitter
- ADNP2 p.Asp944Tyr Uncertain significance Single submitter
- ADNP2 p.Gln376His Uncertain significance Single submitter
- ADNP2 p.Gln524Arg Uncertain significance Single submitter
- ADNP2 p.Gln566Lys Uncertain significance Single submitter
- ADNP2 p.Glu988Lys Uncertain significance Single submitter
- ADNP2 p.Gly468Arg Uncertain significance Single submitter
- ADNP2 p.Ile1073Val Uncertain significance Single submitter
- ADNP2 p.Leu390Phe Uncertain significance Single submitter
- ADNP2 p.Leu498Arg Uncertain significance Single submitter
- ADNP2 p.Leu631Phe Uncertain significance Single submitter
- ADNP2 p.Leu765Met Uncertain significance Single submitter
- ADNP2 p.Leu962Phe Uncertain significance Single submitter
- ADNP2 p.Lys71Asn Uncertain significance Single submitter
- ADNP2 p.Lys89Asn Uncertain significance Single submitter
- ADNP2 p.Met1115Thr Uncertain significance Single submitter
- ADNP2 p.Met460Val Uncertain significance Single submitter
- ADNP2 p.Phe48Leu Uncertain significance Single submitter
- ADNP2 p.Pro130Arg Uncertain significance Single submitter
- ADNP2 p.Pro377Leu Uncertain significance Single submitter
- ADNP2 p.Pro377Ser Uncertain significance Single submitter
- ADNP2 p.Pro423Leu Uncertain significance Single submitter
- ADNP2 p.Pro427Arg Uncertain significance Single submitter
- ADNP2 p.Pro445Arg Uncertain significance Single submitter
- ADNP2 p.Pro445Leu Uncertain significance Single submitter
- ADNP2 p.Pro456Arg Uncertain significance Single submitter
- ADNP2 p.Pro477Ser Uncertain significance Single submitter
- ADNP2 p.Pro494Leu Uncertain significance Single submitter
- ADNP2 p.Ser1108Phe Uncertain significance Single submitter
- ADNP2 p.Ser281Arg Uncertain significance Single submitter
- ADNP2 p.Ser30Asn Uncertain significance Single submitter
- ADNP2 p.Ser30Gly Uncertain significance Single submitter
- ADNP2 p.Ser336Cys Uncertain significance Single submitter
- ADNP2 p.Ser424Phe Uncertain significance Single submitter
- ADNP2 p.Ser521Phe Uncertain significance Single submitter
- ADNP2 p.Ser705Cys Uncertain significance Single submitter
- ADNP2 p.Ser849Cys Uncertain significance Single submitter
- ADNP2 p.Ser973Ile Uncertain significance Single submitter
- ADNP2 p.Thr1012Met Uncertain significance Single submitter
- ADNP2 p.Thr264Met Likely benign Single submitter
- ADNP2 p.Thr746Met Uncertain significance Single submitter
- ADNP2 p.Val389Ala Uncertain significance Single submitter
- ADNP2 p.Val396Leu Uncertain significance Single submitter
- ADNP2 p.Val672Met Likely benign Single submitter
- ADNP2 p.Val710Phe Uncertain significance Single submitter
- ADNP2 p.Val812Phe Uncertain significance Single submitter
All ADNP2 variants
Likely benign 19
- p.Ala932= Single submitter
- p.Asn523Ser Single submitter
- p.Gly195Asp Single submitter
- p.Gly658Ser Single submitter
- p.Ile900Val Single submitter
- p.Met331Val Single submitter
- p.Met639Val Single submitter
- p.Met652Val Single submitter
- p.Met801Val Single submitter
- p.Pro704= Single submitter
- p.Pro883Thr Single submitter
- p.Ser671Asn Single submitter
- p.Ser677Ala Single submitter
- p.Thr264Met Single submitter ⚠
- p.Thr478Ala Single submitter
- p.Thr683Ala Single submitter
- p.Val56Ile Single submitter
- p.Val672Met Single submitter ⚠
- p.Val933Ile Single submitter
Uncertain significance 161
- p.Ala222Thr Single submitter ⚠
- p.Ala271Val Single submitter ⚠
- p.Ala287Thr Single submitter ⚠
- p.Ala326Pro Single submitter ⚠
- p.Ala451Gly Single submitter ⚠
- p.Ala493Ser Single submitter ⚠
- p.Ala511Thr Single submitter ⚠
- p.Ala530Pro Single submitter ⚠
- p.Ala632Val Single submitter ⚠
- p.Ala635Thr Single submitter ⚠
- p.Ala733Ser Single submitter ⚠
- p.Ala814Val Single submitter ⚠
- p.Ala941Val Single submitter ⚠
- p.Arg1049His Single submitter ⚠
- p.Arg1094Thr Single submitter ⚠
- p.Arg132Trp Single submitter ⚠
- p.Arg442Gln Single submitter ⚠
- p.Arg496Trp Single submitter ⚠
- p.Arg837Gln Single submitter ⚠
- p.Arg937Cys Single submitter ⚠
- p.Arg94His Single submitter ⚠
- p.Asn1022Lys Single submitter ⚠
- p.Asn1126Asp Single submitter ⚠
- p.Asn223Ser Single submitter ⚠
- p.Asn368Lys Single submitter ⚠
- p.Asn411Lys Single submitter ⚠
- p.Asn684His Single submitter ⚠
- p.Asn706Ser Single submitter ⚠
- p.Asn90Ile Single submitter ⚠
- p.Asn958Ser Single submitter ⚠
- p.Asp1003Gly Single submitter ⚠
- p.Asp1003His Single submitter ⚠
- p.Asp1033Val Single submitter ⚠
- p.Asp1042His Single submitter ⚠
- p.Asp202Asn Single submitter ⚠
- p.Asp944Tyr Single submitter ⚠
- p.Gln227Leu Single submitter ⚠
- p.Gln376His Single submitter ⚠
- p.Gln483Arg Single submitter ⚠
- p.Gln483His Single submitter ⚠
- p.Gln524Arg Single submitter ⚠
- p.Gln566Lys Single submitter ⚠
- p.Glu1047Lys Single submitter ⚠
- p.Glu207Asp Single submitter ⚠
- p.Glu33Lys Single submitter ⚠
- p.Glu744Gly Single submitter ⚠
- p.Glu760Asp Single submitter ⚠
- p.Glu97Asp Single submitter ⚠
- p.Glu988Lys Single submitter ⚠
- p.Gly121Glu Single submitter ⚠
- p.Gly341Ala Single submitter ⚠
- p.Gly360Arg Single submitter ⚠
- p.Gly468Arg Single submitter ⚠
- p.Gly54Val Single submitter ⚠
- p.Gly868Arg Single submitter ⚠
- p.Gly871Asp Single submitter ⚠
- p.Gly983Ser Single submitter ⚠
- p.Gly993Glu Single submitter ⚠
- p.His293Arg Single submitter ⚠
- p.His780Tyr Single submitter ⚠
- p.His848Arg Single submitter ⚠
- p.His93Arg Single submitter ⚠
- p.His984Arg Single submitter ⚠
- p.Ile1030Val Single submitter ⚠
- p.Ile1073Val Single submitter ⚠
- p.Ile209Thr Single submitter ⚠
- p.Ile209Val Single submitter ⚠
- p.Ile22Val Single submitter ⚠
- p.Ile266Val Single submitter ⚠
- p.Ile509Val Single submitter ⚠
- p.Ile828Val Single submitter ⚠
- p.Ile843Val Single submitter ⚠
- p.Leu142Ser Single submitter ⚠
- p.Leu260His Single submitter ⚠
- p.Leu390Phe Single submitter ⚠
- p.Leu498Arg Single submitter ⚠
- p.Leu631Phe Single submitter ⚠
- p.Leu765Met Single submitter ⚠
- p.Leu765Ser Single submitter ⚠
- p.Leu85Phe Single submitter ⚠
- p.Leu892Gln Single submitter ⚠
- p.Leu962Phe Single submitter ⚠
- p.Lys1010Asn Single submitter ⚠
- p.Lys1010Glu Single submitter ⚠
- p.Lys1044Arg Single submitter ⚠
- p.Lys1103Glu Single submitter ⚠
- p.Lys18Thr Single submitter ⚠
- p.Lys688Thr Single submitter ⚠
- p.Lys71Asn Single submitter ⚠
- p.Lys858Arg Single submitter ⚠
- p.Lys89Asn Single submitter ⚠
- p.Lys943Glu Single submitter ⚠
- p.Met1115Thr Single submitter ⚠
- p.Met331Lys Single submitter ⚠
- p.Met460Val Single submitter ⚠
- p.Met639Ile Single submitter ⚠
- p.Met969Leu Single submitter ⚠
- p.Phe1057Leu Single submitter ⚠
- p.Phe1080Ser Single submitter ⚠
- p.Phe48Leu Single submitter ⚠
- p.Pro1008Ala Single submitter ⚠
- p.Pro130Arg Single submitter ⚠
- p.Pro198Leu Single submitter ⚠
- p.Pro268Ser Single submitter ⚠
- p.Pro308Ser Single submitter ⚠
- p.Pro324Ala Single submitter ⚠
- p.Pro324Ser Single submitter ⚠
- p.Pro354Thr Single submitter ⚠
- p.Pro377Leu Single submitter ⚠
- p.Pro377Ser Single submitter ⚠
- p.Pro423Leu Single submitter ⚠
- p.Pro427Arg Single submitter ⚠
- p.Pro427Ser Single submitter ⚠
- p.Pro445Arg Single submitter ⚠
- p.Pro445Leu Single submitter ⚠
- p.Pro456Arg Single submitter ⚠
- p.Pro477Ser Single submitter ⚠
- p.Pro494Leu Single submitter ⚠
- p.Pro628Ser Single submitter ⚠
- p.Pro636Gln Single submitter ⚠
- p.Pro800Leu Single submitter ⚠
- p.Pro854Ala Single submitter ⚠
- p.Pro883Leu Single submitter ⚠
- p.Pro953Ser Single submitter ⚠
- p.Pro997Ser Single submitter ⚠
- p.Ser1078Leu Single submitter ⚠
- p.Ser1108Phe Single submitter ⚠
- p.Ser281Arg Single submitter ⚠
- p.Ser300Arg Single submitter ⚠
- p.Ser30Asn Single submitter ⚠
- p.Ser30Gly Single submitter ⚠
- p.Ser318Gly Single submitter ⚠
- p.Ser336Cys Single submitter ⚠
- p.Ser424Phe Single submitter ⚠
- p.Ser521Phe Single submitter ⚠
- p.Ser52Leu Single submitter ⚠
- p.Ser587Ala Single submitter ⚠
- p.Ser587Leu Single submitter ⚠
- p.Ser62Tyr Single submitter ⚠
- p.Ser705Cys Single submitter ⚠
- p.Ser849Cys Single submitter ⚠
- p.Ser869Asn Single submitter ⚠
- p.Ser945Arg Single submitter ⚠
- p.Ser973Gly Single submitter ⚠
- p.Ser973Ile Single submitter ⚠
- p.Thr1012Arg Single submitter ⚠
- p.Thr1012Met Single submitter ⚠
- p.Thr1026Ala Single submitter ⚠
- p.Thr478Ile Single submitter ⚠
- p.Thr573Ser Single submitter ⚠
- p.Thr70Arg Single submitter ⚠
- p.Thr746Met Single submitter ⚠
- p.Thr866Ile Single submitter ⚠
- p.Tyr137Cys Single submitter ⚠
- p.Tyr856Cys Single submitter ⚠
- p.Tyr95His Single submitter ⚠
- p.Val105Met Single submitter ⚠
- p.Val389Ala Single submitter ⚠
- p.Val396Leu Single submitter ⚠
- p.Val710Phe Single submitter ⚠
- p.Val812Phe Single submitter ⚠