ADO — 22 ClinVar variants
All ClinVar germline ADO variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 21 flagged for review →
1 Likely benign · 21 Uncertain significance
Full ADO gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 21
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 9
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADO p.Ala146Val Uncertain significance Single submitter
- ADO p.Ala41Val Uncertain significance Single submitter
- ADO p.Arg230Gly Uncertain significance Single submitter
- ADO p.Asp34His Uncertain significance Single submitter
- ADO p.Asp94Glu Uncertain significance Single submitter
- ADO p.Gly29Arg Uncertain significance Single submitter
- ADO p.Pro39Leu Uncertain significance Single submitter
- ADO p.Pro70Arg Uncertain significance Single submitter
- ADO p.Ser236Thr Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- ADO p.Ala14Ser Uncertain significance Single submitter
- ADO p.Arg33Cys Uncertain significance Single submitter
- ADO p.Asp215Val Uncertain significance Single submitter
- ADO p.Asp219Glu Uncertain significance Single submitter
- ADO p.Glu259Gly Uncertain significance Single submitter
- ADO p.Ile130Leu Uncertain significance Single submitter
- ADO p.Leu51Val Uncertain significance Single submitter
- ADO p.Pro144Leu Uncertain significance Single submitter
- ADO p.Pro2Leu Uncertain significance Single submitter
- ADO p.Pro83Leu Uncertain significance Single submitter
- ADO p.Thr186Pro Uncertain significance Single submitter
- ADO p.Val165Met Uncertain significance Single submitter
All ADO variants
Likely benign 1
- p.Gly29Ser Single submitter
Uncertain significance 21
- p.Ala146Val Single submitter ⚠
- p.Ala14Ser Single submitter ⚠
- p.Ala41Val Single submitter ⚠
- p.Arg230Gly Single submitter ⚠
- p.Arg33Cys Single submitter ⚠
- p.Asp215Val Single submitter ⚠
- p.Asp219Glu Single submitter ⚠
- p.Asp34His Single submitter ⚠
- p.Asp94Glu Single submitter ⚠
- p.Glu259Gly Single submitter ⚠
- p.Gly29Arg Single submitter ⚠
- p.Ile130Leu Single submitter ⚠
- p.Leu51Val Single submitter ⚠
- p.Pro144Leu Single submitter ⚠
- p.Pro2Leu Single submitter ⚠
- p.Pro39Leu Single submitter ⚠
- p.Pro70Arg Single submitter ⚠
- p.Pro83Leu Single submitter ⚠
- p.Ser236Thr Single submitter ⚠
- p.Thr186Pro Single submitter ⚠
- p.Val165Met Single submitter ⚠