ADRM1 — 59 ClinVar variants
All ClinVar germline ADRM1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 54 flagged for review →
5 Benign · 54 Uncertain significance
Full ADRM1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 54
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADRM1 p.Ala149Gly Uncertain significance Single submitter
- ADRM1 p.Ala236Thr Uncertain significance Single submitter
- ADRM1 p.Ala239Thr Uncertain significance Single submitter
- ADRM1 p.Ala245Thr Uncertain significance Single submitter
- ADRM1 p.Ala278Val Uncertain significance Single submitter
- ADRM1 p.Ala324Thr Uncertain significance Single submitter
- ADRM1 p.Arg309Cys Uncertain significance Single submitter
- ADRM1 p.Asn329Ser Uncertain significance Single submitter
- ADRM1 p.Asn68Lys Uncertain significance Single submitter
- ADRM1 p.Cys357Tyr Uncertain significance Single submitter
- ADRM1 p.Glu126Lys Uncertain significance Single submitter
- ADRM1 p.Glu153Asp Uncertain significance Single submitter
- ADRM1 p.Glu400Gly Uncertain significance Single submitter
- ADRM1 p.Gly144Ser Uncertain significance Single submitter
- ADRM1 p.Gly392Ser Uncertain significance Single submitter
- ADRM1 p.His120Tyr Uncertain significance Single submitter
- ADRM1 p.Ile270Ser Uncertain significance Single submitter
- ADRM1 p.Ile296Met Uncertain significance Single submitter
- ADRM1 p.Leu33Met Uncertain significance Single submitter
- ADRM1 p.Met342Thr Uncertain significance Single submitter
- ADRM1 p.Met404Val Uncertain significance Single submitter
- ADRM1 p.Pro201Leu Uncertain significance Single submitter
- ADRM1 p.Pro244Ser Uncertain significance Single submitter
- ADRM1 p.Pro246Ser Uncertain significance Single submitter
- ADRM1 p.Pro280Leu Uncertain significance Single submitter
- ADRM1 p.Pro294Leu Uncertain significance Single submitter
- ADRM1 p.Pro40Ser Uncertain significance Single submitter
- ADRM1 p.Ser197Gly Uncertain significance Single submitter
- ADRM1 p.Ser316Pro Uncertain significance Single submitter
Predictors split 25
The independent predictors disagree with each other — read with care.
- ADRM1 p.Arg226Cys Uncertain significance Single submitter
- ADRM1 p.Gln284Arg Uncertain significance Single submitter
- ADRM1 p.Gln382Glu Uncertain significance Single submitter
- ADRM1 p.Glu146Lys Uncertain significance Single submitter
- ADRM1 p.Gly176Ser Uncertain significance Single submitter
- ADRM1 p.Gly279Arg Uncertain significance Single submitter
- ADRM1 p.Leu194Ile Uncertain significance Single submitter
- ADRM1 p.Lys379Arg Uncertain significance Single submitter
- ADRM1 p.Pro229Ala Uncertain significance Single submitter
- ADRM1 p.Pro258Leu Uncertain significance Single submitter
- ADRM1 p.Pro321Leu Uncertain significance Single submitter
- ADRM1 p.Pro86Leu Uncertain significance Single submitter
- ADRM1 p.Pro9Thr Uncertain significance Single submitter
- ADRM1 p.Ser203Ile Uncertain significance Single submitter
- ADRM1 p.Ser223Phe Uncertain significance Single submitter
- ADRM1 p.Ser248Cys Uncertain significance Single submitter
- ADRM1 p.Ser316Cys Uncertain significance Single submitter
- ADRM1 p.Ser319Leu Uncertain significance Single submitter
- ADRM1 p.Ser32Phe Uncertain significance Single submitter
- ADRM1 p.Ser32Tyr Uncertain significance Single submitter
- ADRM1 p.Thr225Ile Uncertain significance Single submitter
- ADRM1 p.Thr273Met Uncertain significance Single submitter
- ADRM1 p.Thr394Met Uncertain significance Single submitter
- ADRM1 p.Thr39Ser Uncertain significance Single submitter
-
ADRM1 p.Pro218Gln
Uncertain significance
No assertion criteria
prostate cancer
All ADRM1 variants
Benign 5
- p.Ala245= Multiple submitters
- p.Ala324Val Multiple submitters
- p.Asp266= Multiple submitters
- p.Pro315= Multiple submitters
- p.Asp53Glu Single submitter
Uncertain significance 54
- p.Ala149Gly Single submitter ⚠
- p.Ala236Thr Single submitter ⚠
- p.Ala239Thr Single submitter ⚠
- p.Ala245Thr Single submitter ⚠
- p.Ala278Val Single submitter ⚠
- p.Ala324Thr Single submitter ⚠
- p.Arg226Cys Single submitter ⚠
- p.Arg309Cys Single submitter ⚠
- p.Asn329Ser Single submitter ⚠
- p.Asn68Lys Single submitter ⚠
- p.Cys357Tyr Single submitter ⚠
- p.Gln284Arg Single submitter ⚠
- p.Gln382Glu Single submitter ⚠
- p.Glu126Lys Single submitter ⚠
- p.Glu146Lys Single submitter ⚠
- p.Glu153Asp Single submitter ⚠
- p.Glu400Gly Single submitter ⚠
- p.Gly144Ser Single submitter ⚠
- p.Gly176Ser Single submitter ⚠
- p.Gly279Arg Single submitter ⚠
- p.Gly392Ser Single submitter ⚠
- p.His120Tyr Single submitter ⚠
- p.Ile270Ser Single submitter ⚠
- p.Ile296Met Single submitter ⚠
- p.Leu194Ile Single submitter ⚠
- p.Leu33Met Single submitter ⚠
- p.Lys379Arg Single submitter ⚠
- p.Met342Thr Single submitter ⚠
- p.Met404Val Single submitter ⚠
- p.Pro201Leu Single submitter ⚠
- p.Pro229Ala Single submitter ⚠
- p.Pro244Ser Single submitter ⚠
- p.Pro246Ser Single submitter ⚠
- p.Pro258Leu Single submitter ⚠
- p.Pro280Leu Single submitter ⚠
- p.Pro294Leu Single submitter ⚠
- p.Pro321Leu Single submitter ⚠
- p.Pro40Ser Single submitter ⚠
- p.Pro86Leu Single submitter ⚠
- p.Pro9Thr Single submitter ⚠
- p.Ser197Gly Single submitter ⚠
- p.Ser203Ile Single submitter ⚠
- p.Ser223Phe Single submitter ⚠
- p.Ser248Cys Single submitter ⚠
- p.Ser316Cys Single submitter ⚠
- p.Ser316Pro Single submitter ⚠
- p.Ser319Leu Single submitter ⚠
- p.Ser32Phe Single submitter ⚠
- p.Ser32Tyr Single submitter ⚠
- p.Thr225Ile Single submitter ⚠
- p.Thr273Met Single submitter ⚠
- p.Thr394Met Single submitter ⚠
- p.Thr39Ser Single submitter ⚠
- p.Pro218Gln No assertion criteria prostate cancer ⚠