ADTRP — 33 ClinVar variants
All ClinVar germline ADTRP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 28 flagged for review →
2 Likely benign · 31 Uncertain significance
Full ADTRP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 28
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADTRP p.Arg145Thr Uncertain significance Single submitter
- ADTRP p.Arg169Cys Uncertain significance Single submitter
- ADTRP p.Asn39Ser Uncertain significance Single submitter
- ADTRP p.Asp65Glu Uncertain significance Single submitter
- ADTRP p.Gln26Arg Uncertain significance Single submitter
- ADTRP p.His10Arg Uncertain significance Single submitter
- ADTRP p.Lys227Arg Uncertain significance Single submitter
- ADTRP p.Lys35Arg Uncertain significance Single submitter
- ADTRP p.Met222Thr Uncertain significance Single submitter
- ADTRP p.Ser168Gly Uncertain significance Single submitter
- ADTRP p.Ser206Ile Uncertain significance Single submitter
- ADTRP p.Thr55Ile Uncertain significance Single submitter
- ADTRP p.Tyr45Phe Uncertain significance Single submitter
- ADTRP p.Val124Leu Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- ADTRP p.Ala205Thr Uncertain significance Single submitter
- ADTRP p.Arg169Ser Uncertain significance Single submitter
- ADTRP p.Arg226Trp Uncertain significance Single submitter
- ADTRP p.Gln54Glu Uncertain significance Single submitter
- ADTRP p.Gly59Val Uncertain significance Single submitter
- ADTRP p.Ile137Asn Uncertain significance Single submitter
- ADTRP p.Ile8Thr Uncertain significance Single submitter
- ADTRP p.Lys153Glu Uncertain significance Single submitter
- ADTRP p.Pro146His Uncertain significance Single submitter
- ADTRP p.Thr132Ser Uncertain significance Single submitter
- ADTRP p.Thr177Met Uncertain significance Single submitter
- ADTRP p.Thr47Met Uncertain significance Single submitter
- ADTRP p.Thr4Ser Uncertain significance Single submitter
- ADTRP p.Tyr17Cys Uncertain significance Single submitter
All ADTRP variants
Likely benign 2
- p.Arg226Gln Single submitter
- p.Val143Ile Single submitter
Uncertain significance 31
- c.154-1655T>C Single submitter
- c.154-1691G>A Single submitter
- c.154-1692A>G Single submitter
- p.Ala205Thr Single submitter ⚠
- p.Arg145Thr Single submitter ⚠
- p.Arg169Cys Single submitter ⚠
- p.Arg169Ser Single submitter ⚠
- p.Arg226Trp Single submitter ⚠
- p.Asn39Ser Single submitter ⚠
- p.Asp65Glu Single submitter ⚠
- p.Gln26Arg Single submitter ⚠
- p.Gln54Glu Single submitter ⚠
- p.Gly59Val Single submitter ⚠
- p.His10Arg Single submitter ⚠
- p.Ile137Asn Single submitter ⚠
- p.Ile8Thr Single submitter ⚠
- p.Lys153Glu Single submitter ⚠
- p.Lys227Arg Single submitter ⚠
- p.Lys35Arg Single submitter ⚠
- p.Met222Thr Single submitter ⚠
- p.Pro146His Single submitter ⚠
- p.Ser168Gly Single submitter ⚠
- p.Ser206Ile Single submitter ⚠
- p.Thr132Ser Single submitter ⚠
- p.Thr177Met Single submitter ⚠
- p.Thr47Met Single submitter ⚠
- p.Thr4Ser Single submitter ⚠
- p.Thr55Ile Single submitter ⚠
- p.Tyr17Cys Single submitter ⚠
- p.Tyr45Phe Single submitter ⚠
- p.Val124Leu Single submitter ⚠