Sugi Variant

Sugi Variant/AGBL5

AGBL5 — 726 ClinVar variants

All ClinVar germline AGBL5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 374 flagged for review →

26 Pathogenic · 16 Likely pathogenic · 7 Conflicting · 17 Benign · 4 Benign/Likely benign · 249 Likely benign · 407 Uncertain significance

Full AGBL5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 374

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 4

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 250

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 250

Predictors split 120

The independent predictors disagree with each other — read with care.

All AGBL5 variants

Pathogenic 26

Likely pathogenic 16

Conflicting classifications of pathogenicity 7

Benign 17

Benign/Likely benign 4

Likely benign 249

Uncertain significance 407

Showing the top 300 by review status; the full set is in the sitemap.