AGPAT1 — 10 ClinVar variants
All ClinVar germline AGPAT1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 9 flagged for review →
1 Likely benign · 9 Uncertain significance
Full AGPAT1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 9
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- AGPAT1 p.Arg263Gln Uncertain significance Single submitter
- AGPAT1 p.Arg270Gln Uncertain significance Single submitter
- AGPAT1 p.Arg83Gln Uncertain significance Single submitter
- AGPAT1 p.Pro279Leu Uncertain significance Single submitter
- AGPAT1 p.Pro279Thr Uncertain significance Single submitter
- AGPAT1 p.Val63Ile Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All AGPAT1 variants
Likely benign 1
- p.Gly282Ser Single submitter
Uncertain significance 9
- p.Arg263Gln Single submitter ⚠
- p.Arg270Gln Single submitter ⚠
- p.Arg83Gln Single submitter ⚠
- p.Gln202Lys Single submitter ⚠
- p.Gly271Ser Single submitter ⚠
- p.Leu22Val Single submitter ⚠
- p.Pro279Leu Single submitter ⚠
- p.Pro279Thr Single submitter ⚠
- p.Val63Ile Single submitter ⚠