AGTRAP — 34 ClinVar variants
All ClinVar germline AGTRAP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 25 flagged for review →
9 Likely benign · 25 Uncertain significance
Full AGTRAP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 25
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- AGTRAP p.Arg130Ser Uncertain significance Single submitter
- AGTRAP p.Arg157Leu Uncertain significance Single submitter
- AGTRAP p.Arg48Gln Uncertain significance Single submitter
- AGTRAP p.Arg48Trp Uncertain significance Single submitter
- AGTRAP p.Arg78Gly Uncertain significance Single submitter
- AGTRAP p.Arg86His Uncertain significance Single submitter
- AGTRAP p.Gly22Asp Uncertain significance Single submitter
- AGTRAP p.Ile51Phe Uncertain significance Single submitter
- AGTRAP p.Ile65Leu Uncertain significance Single submitter
- AGTRAP p.Leu38Val Uncertain significance Single submitter
- AGTRAP p.Pro4Arg Uncertain significance Single submitter
- AGTRAP p.Pro4Ser Uncertain significance Single submitter
- AGTRAP p.Pro77Leu Uncertain significance Single submitter
- AGTRAP p.Ser102Ala Uncertain significance Single submitter
- AGTRAP p.Ser95Thr Uncertain significance Single submitter
- AGTRAP p.Thr135Met Uncertain significance Single submitter
- AGTRAP p.Tyr159Cys Uncertain significance Single submitter
- AGTRAP p.Val106Ile Uncertain significance Single submitter
- AGTRAP p.Val70Met Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- AGTRAP p.Ala53Thr Uncertain significance Single submitter
- AGTRAP p.Arg113Cys Uncertain significance Single submitter
- AGTRAP p.Arg113His Uncertain significance Single submitter
- AGTRAP p.Arg130Cys Uncertain significance Single submitter
- AGTRAP p.Phe75Leu Uncertain significance Single submitter
- AGTRAP p.Thr36Ile Uncertain significance Single submitter
All AGTRAP variants
Likely benign 9
Uncertain significance 25
- p.Ala53Thr Single submitter ⚠
- p.Arg113Cys Single submitter ⚠
- p.Arg113His Single submitter ⚠
- p.Arg130Cys Single submitter ⚠
- p.Arg130Ser Single submitter ⚠
- p.Arg157Leu Single submitter ⚠
- p.Arg48Gln Single submitter ⚠
- p.Arg48Trp Single submitter ⚠
- p.Arg78Gly Single submitter ⚠
- p.Arg86His Single submitter ⚠
- p.Gly22Asp Single submitter ⚠
- p.Ile51Phe Single submitter ⚠
- p.Ile65Leu Single submitter ⚠
- p.Leu38Val Single submitter ⚠
- p.Phe75Leu Single submitter ⚠
- p.Pro4Arg Single submitter ⚠
- p.Pro4Ser Single submitter ⚠
- p.Pro77Leu Single submitter ⚠
- p.Ser102Ala Single submitter ⚠
- p.Ser95Thr Single submitter ⚠
- p.Thr135Met Single submitter ⚠
- p.Thr36Ile Single submitter ⚠
- p.Tyr159Cys Single submitter ⚠
- p.Val106Ile Single submitter ⚠
- p.Val70Met Single submitter ⚠