AKT2 — 223 ClinVar variants
All ClinVar germline AKT2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 74 flagged for review →
1 Pathogenic · 1 Likely pathogenic · 8 Conflicting · 32 Benign · 4 Benign/Likely benign · 102 Likely benign · 75 Uncertain significance
Full AKT2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 74
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
-
AKT2 p.Gly116Ala
Conflicting
Single submitter
hypoinsulinemic hypoglycemia and body hemihypertrophy
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
-
AKT2 p.Arg15His
Uncertain significance
Multiple submitters
hypoinsulinemic hypoglycemia and body hemihypertrophy
-
AKT2 p.Arg347Cys
Uncertain significance
Multiple submitters
type 2 diabetes mellitus
-
AKT2 p.Asp399Asn
Uncertain significance
Multiple submitters
hypoinsulinemic hypoglycemia and body hemihypertrophy
-
AKT2 p.Glu134Ala
Uncertain significance
Multiple submitters
type 2 diabetes mellitus
-
AKT2 p.Arg184Trp
Uncertain significance
Single submitter
hypoinsulinemic hypoglycemia and body hemihypertrophy
-
AKT2 p.Arg224Leu
Uncertain significance
Single submitter
hypoinsulinemic hypoglycemia and body hemihypertrophy
-
AKT2 p.Arg347His
Uncertain significance
Single submitter
type 2 diabetes mellitus
-
AKT2 p.Arg392Trp
Uncertain significance
Single submitter
Inborn genetic diseases
-
AKT2 p.Arg480His
Uncertain significance
Single submitter
type 2 diabetes mellitus
- AKT2 p.Arg76His Uncertain significance Single submitter
-
AKT2 p.Asp192Gly
Uncertain significance
Single submitter
Inborn genetic diseases
-
AKT2 p.Asp284His
Uncertain significance
Single submitter
Inborn genetic diseases
-
AKT2 p.Asp94Glu
Uncertain significance
Single submitter
hypoinsulinemic hypoglycemia and body hemihypertrophy
-
AKT2 p.Gly235Val
Uncertain significance
Single submitter
hypoinsulinemic hypoglycemia and body hemihypertrophy
-
AKT2 p.Gly312Arg
Uncertain significance
Single submitter
Inborn genetic diseases
-
AKT2 p.Gly346Ser
Uncertain significance
Single submitter
type 2 diabetes mellitus
-
AKT2 p.Gly396Arg
Uncertain significance
Single submitter
Inborn genetic diseases
-
AKT2 p.Ile291Val
Uncertain significance
Single submitter
hypoinsulinemic hypoglycemia and body hemihypertrophy
-
AKT2 p.Ile7Val
Uncertain significance
Single submitter
type 2 diabetes mellitus
-
AKT2 p.Leu49Gln
Uncertain significance
Single submitter
Inborn genetic diseases
- AKT2 p.Lys123Thr Uncertain significance Single submitter
-
AKT2 p.Lys390Arg
Uncertain significance
Single submitter
type 2 diabetes mellitus
-
AKT2 p.Met100Arg
Uncertain significance
Single submitter
Inborn genetic diseases
-
AKT2 p.Met105Thr
Uncertain significance
Single submitter
Inborn genetic diseases
-
AKT2 p.Phe369Val
Uncertain significance
Single submitter
Inborn genetic diseases
-
AKT2 p.Pro119Arg
Uncertain significance
Single submitter
Inborn genetic diseases
-
AKT2 p.Pro127Leu
Uncertain significance
Single submitter
type 2 diabetes mellitus
- AKT2 p.Pro42Leu Uncertain significance Single submitter
-
AKT2 p.Pro45Ala
Uncertain significance
Single submitter
Inborn genetic diseases
-
AKT2 p.Pro68Thr
Uncertain significance
Single submitter
Inborn genetic diseases
- AKT2 p.Tyr351Cys Uncertain significance Single submitter
-
AKT2 p.Tyr456Cys
Uncertain significance
Single submitter
Inborn genetic diseases
-
AKT2 p.Val90Met
Uncertain significance
Single submitter
type 2 diabetes mellitus
Predictors split 40
The independent predictors disagree with each other — read with care.
-
AKT2 p.Ala214Val
Uncertain significance
Multiple submitters
AKT2-related disorder
-
AKT2 p.Arg113Trp
Uncertain significance
Multiple submitters
type 2 diabetes mellitus
-
AKT2 p.Gln429Arg
Uncertain significance
Multiple submitters
hypoinsulinemic hypoglycemia and body hemihypertrophy
-
AKT2 p.Thr372Met
Uncertain significance
Multiple submitters
type 2 diabetes mellitus
-
AKT2 p.Ala445Val
Uncertain significance
Single submitter
Inborn genetic diseases
-
AKT2 p.Ala58Val
Likely benign
Single submitter
type 2 diabetes mellitus
-
AKT2 p.Arg101Trp
Uncertain significance
Single submitter
hypoinsulinemic hypoglycemia and body hemihypertrophy
-
AKT2 p.Arg144Trp
Likely benign
Single submitter
type 2 diabetes mellitus
-
AKT2 p.Arg170Trp
Uncertain significance
Single submitter
Inborn genetic diseases
-
AKT2 p.Arg176Cys
Uncertain significance
Single submitter
type 2 diabetes mellitus
- AKT2 p.Arg176His Likely benign Single submitter
-
AKT2 p.Arg176Leu
Uncertain significance
Single submitter
type 2 diabetes mellitus
-
AKT2 p.Arg208Lys
Conflicting
Single submitter
Inborn genetic diseases
-
AKT2 p.Arg224His
Uncertain significance
Single submitter
hypoinsulinemic hypoglycemia and body hemihypertrophy
-
AKT2 p.Arg245Cys
Uncertain significance
Single submitter
Inborn genetic diseases
-
AKT2 p.Arg253Gln
Uncertain significance
Single submitter
hypoinsulinemic hypoglycemia and body hemihypertrophy
-
AKT2 p.Arg357Cys
Likely benign
Single submitter
type 2 diabetes mellitus
-
AKT2 p.Arg368His
Uncertain significance
Single submitter
hypoinsulinemic hypoglycemia and body hemihypertrophy
-
AKT2 p.Arg371Cys
Uncertain significance
Single submitter
type 2 diabetes mellitus
-
AKT2 p.Arg371His
Uncertain significance
Single submitter
hypoinsulinemic hypoglycemia and body hemihypertrophy
-
AKT2 p.Arg455Cys
Uncertain significance
Single submitter
type 2 diabetes mellitus
-
AKT2 p.Arg467Trp
Conflicting
Single submitter
hypoinsulinemic hypoglycemia and body hemihypertrophy
-
AKT2 p.Asn413His
Uncertain significance
Single submitter
hypoinsulinemic hypoglycemia and body hemihypertrophy
-
AKT2 p.Asn71Ser
Conflicting
Single submitter
type 2 diabetes mellitus
-
AKT2 p.Asp192Glu
Uncertain significance
Single submitter
type 2 diabetes mellitus
-
AKT2 p.Asp416Asn
Conflicting
Single submitter
type 2 diabetes mellitus
-
AKT2 p.Asp46Asn
Uncertain significance
Single submitter
type 2 diabetes mellitus
-
AKT2 p.Glu95Lys
Uncertain significance
Single submitter
type 2 diabetes mellitus
-
AKT2 p.Ile189Leu
Uncertain significance
Single submitter
Inborn genetic diseases
- AKT2 p.Ile19Leu Uncertain significance Single submitter
-
AKT2 p.Leu373Val
Uncertain significance
Single submitter
Inborn genetic diseases
-
AKT2 p.Lys156Arg
Uncertain significance
Single submitter
Inborn genetic diseases
-
AKT2 p.Lys191Arg
Uncertain significance
Single submitter
type 2 diabetes mellitus
-
AKT2 p.Met344Ile
Likely benign
Single submitter
type 2 diabetes mellitus
-
AKT2 p.Met364Val
Uncertain significance
Single submitter
type 2 diabetes mellitus
-
AKT2 p.Pro50Thr
Benign
Single submitter
hypoinsulinemic hypoglycemia and body hemihypertrophy
-
AKT2 p.Pro70Ala
Uncertain significance
Single submitter
hypoinsulinemic hypoglycemia and body hemihypertrophy
-
AKT2 p.Thr132Met
Likely benign
Single submitter
type 2 diabetes mellitus
- AKT2 p.Thr431Met Uncertain significance Single submitter
-
AKT2 p.Val57Ile
Uncertain significance
Single submitter
type 2 diabetes mellitus
All AKT2 variants
Pathogenic 1
- p.Glu17Lys Single submitter type 2 diabetes mellitus
Likely pathogenic 1
- p.Arg274His Single submitter type 2 diabetes mellitus
Conflicting classifications of pathogenicity 8
- c.831+4A>G Single submitter type 2 diabetes mellitus
- p.Arg208Lys Single submitter Inborn genetic diseases ⚠
- p.Arg467Trp Single submitter hypoinsulinemic hypoglycemia and body hemihypertrophy ⚠
- p.Asn71Ser Single submitter type 2 diabetes mellitus ⚠
- p.Asp416Asn Single submitter type 2 diabetes mellitus ⚠
- p.Glu315= Single submitter hypoinsulinemic hypoglycemia and body hemihypertrophy
- p.Gly116Ala Single submitter hypoinsulinemic hypoglycemia and body hemihypertrophy ⚠
- p.Pro68= Single submitter type 2 diabetes mellitus
Benign 32
- c.1176-17C>T Multiple submitters type 2 diabetes mellitus
- c.176-36C>T Multiple submitters
- c.288-45G>A Multiple submitters
- c.46+147A>G Multiple submitters
- c.573+25G>C Multiple submitters
- c.573+9C>T Multiple submitters type 2 diabetes mellitus
- c.708+115A>G Multiple submitters
- c.831+182A>G Multiple submitters
- c.831+18C>T Multiple submitters type 2 diabetes mellitus
- c.832-28A>G Multiple submitters
- c.960+59A>G Multiple submitters
- c.*266T>C Multiple submitters
- c.*58C>A Multiple submitters
- c.1175+103G>A Single submitter
- c.175+13A>G Single submitter type 2 diabetes mellitus
- c.176-183AC[8] Single submitter
- c.287+319del Single submitter
- c.288-149T>C Single submitter
- c.288-18dup Single submitter type 2 diabetes mellitus
- c.442-20A>G Single submitter type 2 diabetes mellitus
- c.46+269C>T Single submitter
- c.573+128A>C Single submitter
- c.573+312C>T Single submitter
- c.708+264G>A Single submitter
- c.709-14C>T Single submitter type 2 diabetes mellitus
- c.709-164dup Single submitter
- p.Ala143Thr Single submitter type 2 diabetes mellitus
- p.Arg202= Single submitter hypoinsulinemic hypoglycemia and body hemihypertrophy
- p.His222= Single submitter type 2 diabetes mellitus
- p.Lys172Arg Single submitter hypoinsulinemic hypoglycemia and body hemihypertrophy
- p.Pro50Thr Single submitter hypoinsulinemic hypoglycemia and body hemihypertrophy ⚠
- p.Ser432= Single submitter type 2 diabetes mellitus
Benign/Likely benign 4
- c.1366+20G>A Multiple submitters type 2 diabetes mellitus
- c.*9C>T Multiple submitters
- p.Pro370= Multiple submitters hypoinsulinemic hypoglycemia and body hemihypertrophy
- p.Ser31= Multiple submitters hypoinsulinemic hypoglycemia and body hemihypertrophy
Likely benign 102
- c.1367-7C>T Multiple submitters type 2 diabetes mellitus
- c.442-8C>T Multiple submitters hypoinsulinemic hypoglycemia and body hemihypertrophy
- c.960+3G>A Multiple submitters hypoinsulinemic hypoglycemia and body hemihypertrophy
- c.961-13C>T Multiple submitters hypoinsulinemic hypoglycemia and body hemihypertrophy
- p.Asp94= Multiple submitters hypoinsulinemic hypoglycemia and body hemihypertrophy
- p.Thr199= Multiple submitters type 2 diabetes mellitus
- p.Val106= Multiple submitters hypoinsulinemic hypoglycemia and body hemihypertrophy
- c.1175+13G>A Single submitter hypoinsulinemic hypoglycemia and body hemihypertrophy
- c.1176-10C>G Single submitter type 2 diabetes mellitus
- c.1176-12G>A Single submitter type 2 diabetes mellitus
- c.1264-4G>A Single submitter type 2 diabetes mellitus
- c.1264-4G>T Single submitter type 2 diabetes mellitus
- c.1264-5C>T Single submitter hypoinsulinemic hypoglycemia and body hemihypertrophy
- c.1366+106A>G Single submitter
- c.1366+19C>T Single submitter type 2 diabetes mellitus
- c.176-9T>C Single submitter hypoinsulinemic hypoglycemia and body hemihypertrophy
- c.288-14G>T Single submitter type 2 diabetes mellitus
- c.288-17C>T Single submitter type 2 diabetes mellitus
- c.288-6G>C Single submitter type 2 diabetes mellitus
- c.288-8C>T Single submitter type 2 diabetes mellitus
- c.442-12T>C Single submitter type 2 diabetes mellitus
- c.442-18T>C Single submitter type 2 diabetes mellitus
- c.442-9C>A Single submitter
- c.46+10C>T Single submitter type 2 diabetes mellitus
- c.46+19C>T Single submitter hypoinsulinemic hypoglycemia and body hemihypertrophy
- c.46+20C>T Single submitter type 2 diabetes mellitus
- c.573+8C>T Single submitter type 2 diabetes mellitus
- c.574-15G>A Single submitter type 2 diabetes mellitus
- c.574-16C>G Single submitter type 2 diabetes mellitus
- c.574-16C>T Single submitter type 2 diabetes mellitus
- c.639+11C>G Single submitter type 2 diabetes mellitus
- c.640-20C>T Single submitter type 2 diabetes mellitus
- c.708+10G>A Single submitter hypoinsulinemic hypoglycemia and body hemihypertrophy
- c.708+15C>T Single submitter type 2 diabetes mellitus
- c.708+19_708+20insGCGGCTGCCTTGGCT Single submitter type 2 diabetes mellitus
- c.708+8G>A Single submitter type 2 diabetes mellitus
- c.708+9C>T Single submitter type 2 diabetes mellitus
- c.709-11T>A Single submitter type 2 diabetes mellitus
- c.709-9C>T Single submitter hypoinsulinemic hypoglycemia and body hemihypertrophy
- c.831+10A>G Single submitter hypoinsulinemic hypoglycemia and body hemihypertrophy
- c.832-13A>T Single submitter hypoinsulinemic hypoglycemia and body hemihypertrophy
- c.832-17G>A Single submitter type 2 diabetes mellitus
- c.832-7C>T Single submitter type 2 diabetes mellitus
- c.960+20G>T Single submitter type 2 diabetes mellitus
- p.Ala139= Single submitter
- p.Ala139Val Single submitter type 2 diabetes mellitus
- p.Ala190= Single submitter hypoinsulinemic hypoglycemia and body hemihypertrophy
- p.Ala330= Single submitter type 2 diabetes mellitus
- p.Ala44= Single submitter hypoinsulinemic hypoglycemia and body hemihypertrophy
- p.Ala58Val Single submitter type 2 diabetes mellitus ⚠
- p.Arg144Trp Single submitter type 2 diabetes mellitus ⚠
- p.Arg176His Single submitter ⚠
- p.Arg253Trp Single submitter type 2 diabetes mellitus
- p.Arg274= Single submitter type 2 diabetes mellitus
- p.Arg357Cys Single submitter type 2 diabetes mellitus ⚠
- p.Arg437= Single submitter type 2 diabetes mellitus
- p.Arg480Cys Single submitter hypoinsulinemic hypoglycemia and body hemihypertrophy
- p.Asn233= Single submitter type 2 diabetes mellitus
- p.Asp129= Single submitter type 2 diabetes mellitus
- p.Asp153= Single submitter
- p.Asp32= Single submitter
- p.Cys345= Single submitter hypoinsulinemic hypoglycemia and body hemihypertrophy
- p.Glu264= Single submitter type 2 diabetes mellitus
- p.Glu356= Single submitter type 2 diabetes mellitus
- p.Gly175= Single submitter type 2 diabetes mellitus
- p.His13= Single submitter hypoinsulinemic hypoglycemia and body hemihypertrophy
- p.His355= Single submitter type 2 diabetes mellitus
- p.His89= Single submitter type 2 diabetes mellitus
- p.Ile276= Single submitter
- p.Ile412Leu Single submitter hypoinsulinemic hypoglycemia and body hemihypertrophy
- p.Leu237= Single submitter Inborn genetic diseases
- p.Leu336= Single submitter type 2 diabetes mellitus
- p.Leu348= Single submitter
- p.Leu380= Single submitter hypoinsulinemic hypoglycemia and body hemihypertrophy
- p.Lys123= Single submitter
- p.Lys146= Single submitter type 2 diabetes mellitus
- p.Lys172= Single submitter
- p.Lys285= Single submitter hypoinsulinemic hypoglycemia and body hemihypertrophy
- p.Met344Ile Single submitter type 2 diabetes mellitus ⚠
- p.Phe219= Single submitter
- p.Phe409= Single submitter type 2 diabetes mellitus
- p.Pro375= Single submitter type 2 diabetes mellitus
- p.Pro397fs Single submitter type 2 diabetes mellitus
- p.Pro42= Single submitter type 2 diabetes mellitus
- p.Pro471= Single submitter type 2 diabetes mellitus
- p.Ser109= Single submitter type 2 diabetes mellitus
- p.Ser268= Single submitter type 2 diabetes mellitus
- p.Ser476= Single submitter hypoinsulinemic hypoglycemia and body hemihypertrophy
- p.Ser56= Single submitter type 2 diabetes mellitus
- p.Thr132= Single submitter
- p.Thr132Met Single submitter type 2 diabetes mellitus ⚠
- p.Thr133= Single submitter type 2 diabetes mellitus
- p.Thr444= Single submitter
- p.Thr72= Single submitter hypoinsulinemic hypoglycemia and body hemihypertrophy
- p.Tyr231= Single submitter type 2 diabetes mellitus
- p.Tyr341= Single submitter hypoinsulinemic hypoglycemia and body hemihypertrophy
- p.Val194= Single submitter type 2 diabetes mellitus
- p.Val434= Single submitter type 2 diabetes mellitus
- c.1367-9C>T No assertion criteria AKT2-related disorder
- c.*4G>C No assertion criteria AKT2-related disorder
- p.Lys427= No assertion criteria AKT2-related disorder
- p.Thr162= No assertion criteria AKT2-related disorder
Uncertain significance 75
- c.709-3C>G Multiple submitters type 2 diabetes mellitus
- c.960+3G>T Multiple submitters Inborn genetic diseases
- p.Ala214Val Multiple submitters AKT2-related disorder ⚠
- p.Arg113Trp Multiple submitters type 2 diabetes mellitus ⚠
- p.Arg15His Multiple submitters hypoinsulinemic hypoglycemia and body hemihypertrophy ⚠
- p.Arg347Cys Multiple submitters type 2 diabetes mellitus ⚠
- p.Asp399Asn Multiple submitters hypoinsulinemic hypoglycemia and body hemihypertrophy ⚠
- p.Gln429Arg Multiple submitters hypoinsulinemic hypoglycemia and body hemihypertrophy ⚠
- p.Glu134Ala Multiple submitters type 2 diabetes mellitus ⚠
- p.Thr372Met Multiple submitters type 2 diabetes mellitus ⚠
- c.175+4T>C Single submitter hypoinsulinemic hypoglycemia and body hemihypertrophy
- c.708+7C>T Single submitter
- c.709-3C>T Single submitter type 2 diabetes mellitus
- c.961-2dup Single submitter type 2 diabetes mellitus
- p.Ala445Val Single submitter Inborn genetic diseases ⚠
- p.Arg101Trp Single submitter hypoinsulinemic hypoglycemia and body hemihypertrophy ⚠
- p.Arg170Trp Single submitter Inborn genetic diseases ⚠
- p.Arg176Cys Single submitter type 2 diabetes mellitus ⚠
- p.Arg176Leu Single submitter type 2 diabetes mellitus ⚠
- p.Arg184Trp Single submitter hypoinsulinemic hypoglycemia and body hemihypertrophy ⚠
- p.Arg224His Single submitter hypoinsulinemic hypoglycemia and body hemihypertrophy ⚠
- p.Arg224Leu Single submitter hypoinsulinemic hypoglycemia and body hemihypertrophy ⚠
- p.Arg245Cys Single submitter Inborn genetic diseases ⚠
- p.Arg253Gln Single submitter hypoinsulinemic hypoglycemia and body hemihypertrophy ⚠
- p.Arg347His Single submitter type 2 diabetes mellitus ⚠
- p.Arg368His Single submitter hypoinsulinemic hypoglycemia and body hemihypertrophy ⚠
- p.Arg371Cys Single submitter type 2 diabetes mellitus ⚠
- p.Arg371His Single submitter hypoinsulinemic hypoglycemia and body hemihypertrophy ⚠
- p.Arg392Trp Single submitter Inborn genetic diseases ⚠
- p.Arg455Cys Single submitter type 2 diabetes mellitus ⚠
- p.Arg480His Single submitter type 2 diabetes mellitus ⚠
- p.Arg76His Single submitter ⚠
- p.Asn413His Single submitter hypoinsulinemic hypoglycemia and body hemihypertrophy ⚠
- p.Asp192Glu Single submitter type 2 diabetes mellitus ⚠
- p.Asp192Gly Single submitter Inborn genetic diseases ⚠
- p.Asp284His Single submitter Inborn genetic diseases ⚠
- p.Asp399_Lys401delinsGlu Single submitter type 2 diabetes mellitus
- p.Asp46Asn Single submitter type 2 diabetes mellitus ⚠
- p.Asp94Glu Single submitter hypoinsulinemic hypoglycemia and body hemihypertrophy ⚠
- p.Glu320= Single submitter
- p.Glu95Lys Single submitter type 2 diabetes mellitus ⚠
- p.Gly235Val Single submitter hypoinsulinemic hypoglycemia and body hemihypertrophy ⚠
- p.Gly287= Single submitter
- p.Gly312Arg Single submitter Inborn genetic diseases ⚠
- p.Gly328= Single submitter
- p.Gly346Ser Single submitter type 2 diabetes mellitus ⚠
- p.Gly396Arg Single submitter Inborn genetic diseases ⚠
- p.Ile189Leu Single submitter Inborn genetic diseases ⚠
- p.Ile19Leu Single submitter ⚠
- p.Ile291Val Single submitter hypoinsulinemic hypoglycemia and body hemihypertrophy ⚠
- p.Ile7Val Single submitter type 2 diabetes mellitus ⚠
- p.Leu336fs Single submitter type 2 diabetes mellitus
- p.Leu373Val Single submitter Inborn genetic diseases ⚠
- p.Leu49Gln Single submitter Inborn genetic diseases ⚠
- p.Lys123Thr Single submitter ⚠
- p.Lys156Arg Single submitter Inborn genetic diseases ⚠
- p.Lys191Arg Single submitter type 2 diabetes mellitus ⚠
- p.Lys390Arg Single submitter type 2 diabetes mellitus ⚠
- p.Met100Arg Single submitter Inborn genetic diseases ⚠
- p.Met105Thr Single submitter Inborn genetic diseases ⚠
- p.Met364Val Single submitter type 2 diabetes mellitus ⚠
- p.Phe369Val Single submitter Inborn genetic diseases ⚠
- p.Pro119Arg Single submitter Inborn genetic diseases ⚠
- p.Pro127Leu Single submitter type 2 diabetes mellitus ⚠
- p.Pro42Leu Single submitter ⚠
- p.Pro45Ala Single submitter Inborn genetic diseases ⚠
- p.Pro68Thr Single submitter Inborn genetic diseases ⚠
- p.Pro70Ala Single submitter hypoinsulinemic hypoglycemia and body hemihypertrophy ⚠
- p.Thr248= Single submitter
- p.Thr431Met Single submitter ⚠
- p.Tyr177= Single submitter
- p.Tyr351Cys Single submitter ⚠
- p.Tyr456Cys Single submitter Inborn genetic diseases ⚠
- p.Val57Ile Single submitter type 2 diabetes mellitus ⚠
- p.Val90Met Single submitter type 2 diabetes mellitus ⚠