ALDOC — 46 ClinVar variants
All ClinVar germline ALDOC variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 43 flagged for review →
3 Likely benign · 43 Uncertain significance
Full ALDOC gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 43
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 22
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ALDOC p.Ala136Asp Uncertain significance Single submitter
- ALDOC p.Ala32Ser Uncertain significance Single submitter
- ALDOC p.Arg134Cys Uncertain significance Single submitter
- ALDOC p.Arg134His Uncertain significance Single submitter
- ALDOC p.Arg149Cys Uncertain significance Single submitter
- ALDOC p.Arg173Cys Uncertain significance Single submitter
- ALDOC p.Arg259His Uncertain significance Single submitter
- ALDOC p.Arg304Cys Uncertain significance Single submitter
- ALDOC p.Arg304His Uncertain significance Single submitter
- ALDOC p.Arg60Cys Uncertain significance Single submitter
- ALDOC p.Arg96Gln Uncertain significance Single submitter
- ALDOC p.Cys202Arg Uncertain significance Single submitter
- ALDOC p.His3Asn Uncertain significance Single submitter
- ALDOC p.Ile242Met Uncertain significance Single submitter
- ALDOC p.Ile98Thr Uncertain significance Single submitter
- ALDOC p.Phe79Val Uncertain significance Single submitter
- ALDOC p.Pro159Leu Uncertain significance Single submitter
- ALDOC p.Pro236Leu Uncertain significance Single submitter
- ALDOC p.Pro295Leu Uncertain significance Single submitter
- ALDOC p.Pro295Ser Uncertain significance Single submitter
- ALDOC p.Val151Met Uncertain significance Single submitter
- ALDOC p.Val170Met Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- ALDOC p.Ala297Thr Uncertain significance Single submitter
- ALDOC p.Ala297Val Uncertain significance Single submitter
- ALDOC p.Arg157Cys Uncertain significance Single submitter
- ALDOC p.Arg201His Uncertain significance Single submitter
- ALDOC p.Arg22Gln Uncertain significance Single submitter
- ALDOC p.Arg289Cys Uncertain significance Single submitter
- ALDOC p.Asn169Ser Uncertain significance Single submitter
- ALDOC p.Asp120Val Uncertain significance Single submitter
- ALDOC p.Gln126Glu Uncertain significance Single submitter
- ALDOC p.Gln12Glu Uncertain significance Single submitter
- ALDOC p.Glu54Lys Uncertain significance Single submitter
- ALDOC p.Gly75Ala Uncertain significance Single submitter
- ALDOC p.Ile19Val Uncertain significance Single submitter
- ALDOC p.Lys200Arg Uncertain significance Single submitter
- ALDOC p.Pro115Ala Uncertain significance Single submitter
- ALDOC p.Pro26Leu Uncertain significance Single submitter
- ALDOC p.Pro6Leu Uncertain significance Single submitter
- ALDOC p.Val114Ala Uncertain significance Single submitter
- ALDOC p.Val205Ile Uncertain significance Single submitter
- ALDOC p.Val24Ala Uncertain significance Single submitter
- ALDOC p.Val77Ile Uncertain significance Single submitter
All ALDOC variants
Likely benign 3
- p.Arg318= Single submitter
- p.Asn169= Single submitter
- p.Phe282Leu Single submitter
Uncertain significance 43
- p.Ala136Asp Single submitter ⚠
- p.Ala297Thr Single submitter ⚠
- p.Ala297Val Single submitter ⚠
- p.Ala32Ser Single submitter ⚠
- p.Arg134Cys Single submitter ⚠
- p.Arg134His Single submitter ⚠
- p.Arg149Cys Single submitter ⚠
- p.Arg157Cys Single submitter ⚠
- p.Arg173Cys Single submitter ⚠
- p.Arg201His Single submitter ⚠
- p.Arg22Gln Single submitter ⚠
- p.Arg259His Single submitter ⚠
- p.Arg289Cys Single submitter ⚠
- p.Arg304Cys Single submitter ⚠
- p.Arg304His Single submitter ⚠
- p.Arg60Cys Single submitter ⚠
- p.Arg96Gln Single submitter ⚠
- p.Asn169Ser Single submitter ⚠
- p.Asp120Val Single submitter ⚠
- p.Cys202Arg Single submitter ⚠
- p.Gln126Glu Single submitter ⚠
- p.Gln12Glu Single submitter ⚠
- p.Glu54Lys Single submitter ⚠
- p.Gly75Ala Single submitter ⚠
- p.His3Asn Single submitter ⚠
- p.Ile19Val Single submitter ⚠
- p.Ile242Met Single submitter ⚠
- p.Ile98Thr Single submitter ⚠
- p.Lys200Arg Single submitter ⚠
- p.Phe79Val Single submitter ⚠
- p.Pro115Ala Single submitter ⚠
- p.Pro159Leu Single submitter ⚠
- p.Pro236Leu Single submitter ⚠
- p.Pro26Leu Single submitter ⚠
- p.Pro295Leu Single submitter ⚠
- p.Pro295Ser Single submitter ⚠
- p.Pro6Leu Single submitter ⚠
- p.Val114Ala Single submitter ⚠
- p.Val151Met Single submitter ⚠
- p.Val170Met Single submitter ⚠
- p.Val205Ile Single submitter ⚠
- p.Val24Ala Single submitter ⚠
- p.Val77Ile Single submitter ⚠