ALG10B — 88 ClinVar variants
All ClinVar germline ALG10B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 77 flagged for review →
2 Benign · 8 Likely benign · 78 Uncertain significance
Full ALG10B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 77
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 59
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ALG10B p.Ala125Asp Uncertain significance Single submitter
- ALG10B p.Ala163Val Uncertain significance Single submitter
- ALG10B p.Ala2Ser Uncertain significance Single submitter
- ALG10B p.Ala2Val Uncertain significance Single submitter
- ALG10B p.Ala385Val Uncertain significance Single submitter
- ALG10B p.Arg186Trp Uncertain significance Single submitter
- ALG10B p.Arg416His Uncertain significance Single submitter
- ALG10B p.Arg426Gly Uncertain significance Single submitter
- ALG10B p.Asn107Thr Uncertain significance Single submitter
- ALG10B p.Asn246His Uncertain significance Single submitter
- ALG10B p.Asp467Gly Uncertain significance Single submitter
- ALG10B p.Asp59Glu Uncertain significance Single submitter
- ALG10B p.Gln129Arg Uncertain significance Single submitter
- ALG10B p.Gln466Pro Uncertain significance Single submitter
- ALG10B p.Gly179Arg Uncertain significance Single submitter
- ALG10B p.His88Arg Uncertain significance Single submitter
- ALG10B p.Ile128Asn Uncertain significance Single submitter
- ALG10B p.Ile223Val Uncertain significance Single submitter
- ALG10B p.Ile233Ser Uncertain significance Single submitter
- ALG10B p.Ile276Thr Uncertain significance Single submitter
- ALG10B p.Ile378Val Uncertain significance Single submitter
- ALG10B p.Ile401Leu Uncertain significance Single submitter
- ALG10B p.Ile419Val Uncertain significance Single submitter
- ALG10B p.Leu110Ser Uncertain significance Single submitter
- ALG10B p.Leu135Ser Uncertain significance Single submitter
- ALG10B p.Leu299Phe Uncertain significance Single submitter
- ALG10B p.Leu306Val Uncertain significance Single submitter
- ALG10B p.Leu336Val Uncertain significance Single submitter
- ALG10B p.Leu420Phe Uncertain significance Single submitter
- ALG10B p.Leu55Val Uncertain significance Single submitter
- ALG10B p.Lys117Asn Uncertain significance Single submitter
- ALG10B p.Lys458Gln Uncertain significance Single submitter
- ALG10B p.Lys77Thr Uncertain significance Single submitter
- ALG10B p.Met184Ile Uncertain significance Single submitter
- ALG10B p.Met36Arg Uncertain significance Single submitter
- ALG10B p.Met36Leu Uncertain significance Single submitter
- ALG10B p.Met36Thr Uncertain significance Single submitter
- ALG10B p.Phe267Leu Uncertain significance Single submitter
- ALG10B p.Phe40Leu Uncertain significance Single submitter
- ALG10B p.Pro120Leu Uncertain significance Single submitter
- ALG10B p.Pro141Ser Uncertain significance Single submitter
- ALG10B p.Pro226Gln Uncertain significance Single submitter
- ALG10B p.Pro375Ser Uncertain significance Single submitter
- ALG10B p.Pro421Arg Uncertain significance Single submitter
- ALG10B p.Pro432Leu Uncertain significance Single submitter
- ALG10B p.Pro463Ser Uncertain significance Single submitter
- ALG10B p.Ser104Gly Uncertain significance Single submitter
- ALG10B p.Ser25Cys Uncertain significance Single submitter
- ALG10B p.Ser310Arg Uncertain significance Single submitter
- ALG10B p.Ser310Asn Uncertain significance Single submitter
- ALG10B p.Ser333Phe Uncertain significance Single submitter
- ALG10B p.Thr16Ser Uncertain significance Single submitter
- ALG10B p.Tyr151Asn Uncertain significance Single submitter
- ALG10B p.Tyr169Cys Uncertain significance Single submitter
- ALG10B p.Tyr35Cys Uncertain significance Single submitter
- ALG10B p.Tyr453Phe Uncertain significance Single submitter
- ALG10B p.Val194Ile Uncertain significance Single submitter
- ALG10B p.Val268Ile Uncertain significance Single submitter
- ALG10B p.Val423Asp Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- ALG10B p.Ala176Gly Uncertain significance Single submitter
- ALG10B p.Ala26Pro Likely benign Single submitter
- ALG10B p.Arg279Gln Uncertain significance Single submitter
- ALG10B p.Arg279Trp Uncertain significance Single submitter
- ALG10B p.Asn147Lys Uncertain significance Single submitter
- ALG10B p.Gln3Pro Uncertain significance Single submitter
- ALG10B p.Gly261Arg Uncertain significance Single submitter
- ALG10B p.His305Arg Uncertain significance Single submitter
- ALG10B p.Ile62Thr Uncertain significance Single submitter
- ALG10B p.Leu114Phe Uncertain significance Single submitter
- ALG10B p.Lys311Glu Uncertain significance Single submitter
- ALG10B p.Lys370Asn Uncertain significance Single submitter
- ALG10B p.Met472Val Uncertain significance Single submitter
- ALG10B p.Phe158Ile Uncertain significance Single submitter
- ALG10B p.Ser20Pro Uncertain significance Single submitter
- ALG10B p.Ser442Arg Uncertain significance Single submitter
- ALG10B p.Thr451Ile Uncertain significance Single submitter
- ALG10B p.Tyr35Phe Uncertain significance Single submitter
All ALG10B variants
Benign 2
- p.Gln469= Multiple submitters
- p.Ser465fs Single submitter
Likely benign 8
- p.Ala26Pro Single submitter ⚠
- p.Ile405Thr Single submitter
- p.Ile407Thr Single submitter
- p.Leu253Trp Single submitter
- p.Leu325Gln Single submitter
- p.Met249Val Single submitter
- p.Pro392Ser Single submitter
- p.Thr430Pro Single submitter
Uncertain significance 78
- p.Ala125Asp Single submitter ⚠
- p.Ala163Val Single submitter ⚠
- p.Ala176Gly Single submitter ⚠
- p.Ala2Ser Single submitter ⚠
- p.Ala2Val Single submitter ⚠
- p.Ala385Val Single submitter ⚠
- p.Arg186Trp Single submitter ⚠
- p.Arg279Gln Single submitter ⚠
- p.Arg279Trp Single submitter ⚠
- p.Arg416His Single submitter ⚠
- p.Arg426Gly Single submitter ⚠
- p.Asn107Thr Single submitter ⚠
- p.Asn147Lys Single submitter ⚠
- p.Asn246His Single submitter ⚠
- p.Asp467Gly Single submitter ⚠
- p.Asp59Glu Single submitter ⚠
- p.Gln129Arg Single submitter ⚠
- p.Gln3Pro Single submitter ⚠
- p.Gln466Pro Single submitter ⚠
- p.Gly179Arg Single submitter ⚠
- p.Gly261Arg Single submitter ⚠
- p.His305Arg Single submitter ⚠
- p.His88Arg Single submitter ⚠
- p.Ile128Asn Single submitter ⚠
- p.Ile223Val Single submitter ⚠
- p.Ile233Ser Single submitter ⚠
- p.Ile276Thr Single submitter ⚠
- p.Ile378Val Single submitter ⚠
- p.Ile401Leu Single submitter ⚠
- p.Ile419Val Single submitter ⚠
- p.Ile62Thr Single submitter ⚠
- p.Leu110Ser Single submitter ⚠
- p.Leu114Phe Single submitter ⚠
- p.Leu135Ser Single submitter ⚠
- p.Leu299Phe Single submitter ⚠
- p.Leu306Val Single submitter ⚠
- p.Leu336Val Single submitter ⚠
- p.Leu420Phe Single submitter ⚠
- p.Leu427Phe Single submitter
- p.Leu55Val Single submitter ⚠
- p.Lys117Asn Single submitter ⚠
- p.Lys311Glu Single submitter ⚠
- p.Lys370Asn Single submitter ⚠
- p.Lys458Gln Single submitter ⚠
- p.Lys77Thr Single submitter ⚠
- p.Met184Ile Single submitter ⚠
- p.Met36Arg Single submitter ⚠
- p.Met36Leu Single submitter ⚠
- p.Met36Thr Single submitter ⚠
- p.Met472Val Single submitter ⚠
- p.Phe158Ile Single submitter ⚠
- p.Phe267Leu Single submitter ⚠
- p.Phe40Leu Single submitter ⚠
- p.Pro120Leu Single submitter ⚠
- p.Pro141Ser Single submitter ⚠
- p.Pro226Gln Single submitter ⚠
- p.Pro375Ser Single submitter ⚠
- p.Pro421Arg Single submitter ⚠
- p.Pro432Leu Single submitter ⚠
- p.Pro463Ser Single submitter ⚠
- p.Ser104Gly Single submitter ⚠
- p.Ser20Pro Single submitter ⚠
- p.Ser25Cys Single submitter ⚠
- p.Ser310Arg Single submitter ⚠
- p.Ser310Asn Single submitter ⚠
- p.Ser333Phe Single submitter ⚠
- p.Ser442Arg Single submitter ⚠
- p.Thr16Ser Single submitter ⚠
- p.Thr451Ile Single submitter ⚠
- p.Tyr151Asn Single submitter ⚠
- p.Tyr169Cys Single submitter ⚠
- p.Tyr35Cys Single submitter ⚠
- p.Tyr35Phe Single submitter ⚠
- p.Tyr453Phe Single submitter ⚠
- p.Val194Ile Single submitter ⚠
- p.Val268Ile Single submitter ⚠
- p.Val423Asp Single submitter ⚠
- p.Ser126Ter No assertion criteria