ALOX15B — 127 ClinVar variants
All ClinVar germline ALOX15B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 111 flagged for review →
2 Benign · 10 Likely benign · 115 Uncertain significance
Full ALOX15B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 111
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 75
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ALOX15B p.Arg461Gln Uncertain significance Multiple submitters
- ALOX15B p.Ala113Val Uncertain significance Single submitter
- ALOX15B p.Ala191Thr Uncertain significance Single submitter
- ALOX15B p.Ala224Thr Uncertain significance Single submitter
- ALOX15B p.Ala239Ser Uncertain significance Single submitter
- ALOX15B p.Ala239Thr Uncertain significance Single submitter
- ALOX15B p.Arg208Gly Uncertain significance Single submitter
- ALOX15B p.Arg220Trp Uncertain significance Single submitter
- ALOX15B p.Arg252His Uncertain significance Single submitter
- ALOX15B p.Arg429Met Uncertain significance Single submitter
- ALOX15B p.Arg634Gln Uncertain significance Single submitter
- ALOX15B p.Arg90Cys Uncertain significance Single submitter
- ALOX15B p.Arg90Ser Uncertain significance Single submitter
- ALOX15B p.Asn173Ser Uncertain significance Single submitter
- ALOX15B p.Asn183Asp Uncertain significance Single submitter
- ALOX15B p.Asn218Thr Uncertain significance Single submitter
- ALOX15B p.Asn40Ser Uncertain significance Single submitter
- ALOX15B p.Asp163Glu Uncertain significance Single submitter
- ALOX15B p.Asp169Gly Uncertain significance Single submitter
- ALOX15B p.Cys549Ser Uncertain significance Single submitter
- ALOX15B p.Gln308Pro Uncertain significance Single submitter
- ALOX15B p.Gln641Arg Uncertain significance Single submitter
- ALOX15B p.Glu141Asp Uncertain significance Single submitter
- ALOX15B p.Glu283Gln Uncertain significance Single submitter
- ALOX15B p.Glu50Ala Uncertain significance Single submitter
- ALOX15B p.Glu524Lys Uncertain significance Single submitter
- ALOX15B p.Gly275Arg Uncertain significance Single submitter
- ALOX15B p.Gly28Arg Uncertain significance Single submitter
- ALOX15B p.Gly338Ser Uncertain significance Single submitter
- ALOX15B p.Gly650Val Uncertain significance Single submitter
- ALOX15B p.Gly657Asp Uncertain significance Single submitter
- ALOX15B p.His378Arg Uncertain significance Single submitter
- ALOX15B p.His553Tyr Uncertain significance Single submitter
- ALOX15B p.Ile174Val Uncertain significance Single submitter
- ALOX15B p.Ile343Val Uncertain significance Single submitter
- ALOX15B p.Ile433Val Uncertain significance Single submitter
- ALOX15B p.Ile591Val Uncertain significance Single submitter
- ALOX15B p.Ile647Asn Uncertain significance Single submitter
- ALOX15B p.Ile651Asn Uncertain significance Single submitter
- ALOX15B p.Leu206Phe Uncertain significance Single submitter
- ALOX15B p.Leu243Pro Uncertain significance Single submitter
- ALOX15B p.Leu398Pro Uncertain significance Single submitter
- ALOX15B p.Leu538Pro Uncertain significance Single submitter
- ALOX15B p.Leu594Ile Uncertain significance Single submitter
- ALOX15B p.Leu594Pro Uncertain significance Single submitter
- ALOX15B p.Lys196Asn Uncertain significance Single submitter
- ALOX15B p.Lys357Gln Uncertain significance Single submitter
- ALOX15B p.Lys71Met Uncertain significance Single submitter
- ALOX15B p.Met148Thr Uncertain significance Single submitter
- ALOX15B p.Met267Lys Uncertain significance Single submitter
- ALOX15B p.Met544Thr Uncertain significance Single submitter
- ALOX15B p.Phe184Ser Uncertain significance Single submitter
- ALOX15B p.Phe344Cys Uncertain significance Single submitter
- ALOX15B p.Phe344Leu Uncertain significance Single submitter
- ALOX15B p.Phe365Ile Uncertain significance Single submitter
- ALOX15B p.Pro105Arg Uncertain significance Single submitter
- ALOX15B p.Pro105Thr Uncertain significance Single submitter
- ALOX15B p.Pro37Ser Uncertain significance Single submitter
- ALOX15B p.Pro624Leu Uncertain significance Single submitter
- ALOX15B p.Pro667Ser Uncertain significance Single submitter
- ALOX15B p.Pro668Leu Uncertain significance Single submitter
- ALOX15B p.Pro84Arg Uncertain significance Single submitter
- ALOX15B p.Ser501Phe Uncertain significance Single submitter
- ALOX15B p.Ser525Asn Uncertain significance Single submitter
- ALOX15B p.Thr166Ala Uncertain significance Single submitter
- ALOX15B p.Thr336Ile Uncertain significance Single submitter
- ALOX15B p.Thr385Asn Uncertain significance Single submitter
- ALOX15B p.Thr56Ala Uncertain significance Single submitter
- ALOX15B p.Trp566Cys Uncertain significance Single submitter
- ALOX15B p.Trp91Arg Uncertain significance Single submitter
- ALOX15B p.Tyr473His Uncertain significance Single submitter
- ALOX15B p.Val133Met Uncertain significance Single submitter
- ALOX15B p.Val263Phe Uncertain significance Single submitter
- ALOX15B p.Val556Ile Uncertain significance Single submitter
- ALOX15B p.Val674Ile Uncertain significance Single submitter
Predictors split 36
The independent predictors disagree with each other — read with care.
- ALOX15B p.Leu257Phe Likely benign Multiple submitters
- ALOX15B p.Ala416Ser Uncertain significance Single submitter
- ALOX15B p.Ala510Asp Uncertain significance Single submitter
- ALOX15B p.Ala551Thr Uncertain significance Single submitter
- ALOX15B p.Ala554Val Uncertain significance Single submitter
- ALOX15B p.Arg253Cys Uncertain significance Single submitter
- ALOX15B p.Arg361Cys Uncertain significance Single submitter
- ALOX15B p.Arg390Cys Uncertain significance Single submitter
- ALOX15B p.Arg634Trp Uncertain significance Single submitter
- ALOX15B p.Arg654Gln Uncertain significance Single submitter
- ALOX15B p.Arg98Trp Uncertain significance Single submitter
- ALOX15B p.Cys601Trp Uncertain significance Single submitter
- ALOX15B p.Gly189Asp Uncertain significance Single submitter
- ALOX15B p.Gly285Asp Uncertain significance Single submitter
- ALOX15B p.Gly285Ser Uncertain significance Single submitter
- ALOX15B p.Gly324Arg Uncertain significance Single submitter
- ALOX15B p.Gly434Ser Uncertain significance Single submitter
- ALOX15B p.Gly437Ser Uncertain significance Single submitter
- ALOX15B p.Gly519Ala Uncertain significance Single submitter
- ALOX15B p.Gly80Arg Uncertain significance Single submitter
- ALOX15B p.Ile546Thr Uncertain significance Single submitter
- ALOX15B p.Met267Val Uncertain significance Single submitter
- ALOX15B p.Phe104Leu Uncertain significance Single submitter
- ALOX15B p.Phe261Leu Uncertain significance Single submitter
- ALOX15B p.Phe640Leu Uncertain significance Single submitter
- ALOX15B p.Pro313Ser Uncertain significance Single submitter
- ALOX15B p.Pro325Leu Uncertain significance Single submitter
- ALOX15B p.Pro342Leu Uncertain significance Single submitter
- ALOX15B p.Pro596Leu Uncertain significance Single submitter
- ALOX15B p.Ser296Pro Uncertain significance Single submitter
- ALOX15B p.Ser33Arg Uncertain significance Single submitter
- ALOX15B p.Ser33Cys Uncertain significance Single submitter
- ALOX15B p.Ser452Cys Uncertain significance Single submitter
- ALOX15B p.Tyr451Cys Uncertain significance Single submitter
- ALOX15B p.Tyr623Cys Uncertain significance Single submitter
- ALOX15B p.Val539Ala Uncertain significance Single submitter
All ALOX15B variants
Benign 2
- p.Arg635Gln Multiple submitters
- c.997-6C>T Single submitter
Likely benign 10
- p.Leu257Phe Multiple submitters ⚠
- p.Ala228Thr Single submitter
- p.Arg486= Single submitter
- p.Arg643His Single submitter
- p.Arg98Gln Single submitter
- p.Asp163Gly Single submitter
- p.Gln299Arg Single submitter
- p.Gln523Arg Single submitter
- p.Glu168Lys Single submitter
- p.Leu329= Single submitter
Uncertain significance 115
- p.Arg461Gln Multiple submitters ⚠
- p.Ala113Val Single submitter ⚠
- p.Ala191Thr Single submitter ⚠
- p.Ala224Thr Single submitter ⚠
- p.Ala239Ser Single submitter ⚠
- p.Ala239Thr Single submitter ⚠
- p.Ala416Ser Single submitter ⚠
- p.Ala510Asp Single submitter ⚠
- p.Ala551Thr Single submitter ⚠
- p.Ala554Val Single submitter ⚠
- p.Arg208Gly Single submitter ⚠
- p.Arg220Trp Single submitter ⚠
- p.Arg252His Single submitter ⚠
- p.Arg253Cys Single submitter ⚠
- p.Arg361Cys Single submitter ⚠
- p.Arg390Cys Single submitter ⚠
- p.Arg407Gly Single submitter
- p.Arg417Trp Single submitter
- p.Arg429Met Single submitter ⚠
- p.Arg634Gln Single submitter ⚠
- p.Arg634Trp Single submitter ⚠
- p.Arg654Gln Single submitter ⚠
- p.Arg90Cys Single submitter ⚠
- p.Arg90Ser Single submitter ⚠
- p.Arg98Trp Single submitter ⚠
- p.Asn173Ser Single submitter ⚠
- p.Asn183Asp Single submitter ⚠
- p.Asn218Thr Single submitter ⚠
- p.Asn40Ser Single submitter ⚠
- p.Asp163Glu Single submitter ⚠
- p.Asp169Gly Single submitter ⚠
- p.Cys549Ser Single submitter ⚠
- p.Cys601Trp Single submitter ⚠
- p.Gln308Pro Single submitter ⚠
- p.Gln641Arg Single submitter ⚠
- p.Glu141Asp Single submitter ⚠
- p.Glu283Gln Single submitter ⚠
- p.Glu50Ala Single submitter ⚠
- p.Glu524Lys Single submitter ⚠
- p.Gly17Asp Single submitter
- p.Gly189Asp Single submitter ⚠
- p.Gly275Arg Single submitter ⚠
- p.Gly285Asp Single submitter ⚠
- p.Gly285Ser Single submitter ⚠
- p.Gly28Arg Single submitter ⚠
- p.Gly324Arg Single submitter ⚠
- p.Gly338Ser Single submitter ⚠
- p.Gly434Ser Single submitter ⚠
- p.Gly437Ser Single submitter ⚠
- p.Gly519Ala Single submitter ⚠
- p.Gly650Val Single submitter ⚠
- p.Gly657Asp Single submitter ⚠
- p.Gly80Arg Single submitter ⚠
- p.His378Arg Single submitter ⚠
- p.His553Tyr Single submitter ⚠
- p.Ile174Val Single submitter ⚠
- p.Ile343Val Single submitter ⚠
- p.Ile433Val Single submitter ⚠
- p.Ile546Thr Single submitter ⚠
- p.Ile591Val Single submitter ⚠
- p.Ile647Asn Single submitter ⚠
- p.Ile651Asn Single submitter ⚠
- p.Leu206Phe Single submitter ⚠
- p.Leu243Pro Single submitter ⚠
- p.Leu398Pro Single submitter ⚠
- p.Leu538Pro Single submitter ⚠
- p.Leu594Ile Single submitter ⚠
- p.Leu594Pro Single submitter ⚠
- p.Lys196Asn Single submitter ⚠
- p.Lys357Gln Single submitter ⚠
- p.Lys71Met Single submitter ⚠
- p.Met148Thr Single submitter ⚠
- p.Met267Lys Single submitter ⚠
- p.Met267Val Single submitter ⚠
- p.Met544Thr Single submitter ⚠
- p.Phe104Leu Single submitter ⚠
- p.Phe184Ser Single submitter ⚠
- p.Phe261Leu Single submitter ⚠
- p.Phe309Ser Single submitter
- p.Phe344Cys Single submitter ⚠
- p.Phe344Leu Single submitter ⚠
- p.Phe365Ile Single submitter ⚠
- p.Phe640Leu Single submitter ⚠
- p.Pro105Arg Single submitter ⚠
- p.Pro105Thr Single submitter ⚠
- p.Pro313Ser Single submitter ⚠
- p.Pro325Leu Single submitter ⚠
- p.Pro342Leu Single submitter ⚠
- p.Pro37Ser Single submitter ⚠
- p.Pro596Leu Single submitter ⚠
- p.Pro624Leu Single submitter ⚠
- p.Pro667Ser Single submitter ⚠
- p.Pro668Leu Single submitter ⚠
- p.Pro84Arg Single submitter ⚠
- p.Ser296Pro Single submitter ⚠
- p.Ser33Arg Single submitter ⚠
- p.Ser33Cys Single submitter ⚠
- p.Ser452Cys Single submitter ⚠
- p.Ser501Phe Single submitter ⚠
- p.Ser525Asn Single submitter ⚠
- p.Thr166Ala Single submitter ⚠
- p.Thr336Ile Single submitter ⚠
- p.Thr385Asn Single submitter ⚠
- p.Thr56Ala Single submitter ⚠
- p.Trp207Ter Single submitter
- p.Trp566Cys Single submitter ⚠
- p.Trp91Arg Single submitter ⚠
- p.Tyr451Cys Single submitter ⚠
- p.Tyr473His Single submitter ⚠
- p.Tyr623Cys Single submitter ⚠
- p.Val133Met Single submitter ⚠
- p.Val263Phe Single submitter ⚠
- p.Val539Ala Single submitter ⚠
- p.Val556Ile Single submitter ⚠
- p.Val674Ile Single submitter ⚠