ANAPC10 — 22 ClinVar variants
All ClinVar germline ANAPC10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 21 flagged for review →
22 Uncertain significance
Full ANAPC10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 21
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANAPC10 p.Arg172Gly Uncertain significance Single submitter
- ANAPC10 p.Arg182His Uncertain significance Single submitter
- ANAPC10 p.Arg23Trp Uncertain significance Single submitter
- ANAPC10 p.Asp47Gly Uncertain significance Single submitter
- ANAPC10 p.Gly118Arg Uncertain significance Single submitter
- ANAPC10 p.Gly118Ser Uncertain significance Single submitter
- ANAPC10 p.Gly41Ala Uncertain significance Single submitter
- ANAPC10 p.Ile156Ser Uncertain significance Single submitter
- ANAPC10 p.Leu50Val Uncertain significance Single submitter
- ANAPC10 p.Pro161Gln Uncertain significance Single submitter
- ANAPC10 p.Pro8Leu Uncertain significance Single submitter
- ANAPC10 p.Ser165Asn Uncertain significance Single submitter
- ANAPC10 p.Thr160Ile Uncertain significance Single submitter
- ANAPC10 p.Thr21Ile Uncertain significance Single submitter
- ANAPC10 p.Tyr159Phe Uncertain significance Single submitter
- ANAPC10 p.Val42Leu Uncertain significance Single submitter
- ANAPC10 p.Val98Ala Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All ANAPC10 variants
Uncertain significance 22
- p.Ala140Val Single submitter ⚠
- p.Arg172Gly Single submitter ⚠
- p.Arg182His Single submitter ⚠
- p.Arg23Trp Single submitter ⚠
- p.Asn65Thr Single submitter ⚠
- p.Asp47Gly Single submitter ⚠
- p.Gly118Arg Single submitter ⚠
- p.Gly118Ser Single submitter ⚠
- p.Gly168Asp Single submitter ⚠
- p.Gly41Ala Single submitter ⚠
- p.Ile156Ser Single submitter ⚠
- p.Leu50Val Single submitter ⚠
- p.Phe40Val Single submitter ⚠
- p.Pro161Gln Single submitter ⚠
- p.Pro8Leu Single submitter ⚠
- p.Ser165Asn Single submitter ⚠
- p.Ser32Ter Single submitter Mayer-Rokitansky-Kuster-Hauser syndrome type 1
- p.Thr160Ile Single submitter ⚠
- p.Thr21Ile Single submitter ⚠
- p.Tyr159Phe Single submitter ⚠
- p.Val42Leu Single submitter ⚠
- p.Val98Ala Single submitter ⚠