ANAPC11 — 23 ClinVar variants
All ClinVar germline ANAPC11 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 6 flagged for review →
2 Likely benign · 21 Uncertain significance
Full ANAPC11 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 6
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 2
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 4
The independent predictors disagree with each other — read with care.
All ANAPC11 variants
Likely benign 2
- c.110-468T>C Single submitter
- p.Lys83Arg Single submitter ⚠
Uncertain significance 21
- c.110-409C>A Single submitter
- c.110-414C>T Single submitter
- c.110-423T>C Single submitter
- c.110-430G>A Single submitter
- c.110-453C>T Single submitter
- c.110-490G>A Single submitter
- c.110-499C>T Single submitter
- c.110-595C>A Single submitter
- c.110-616C>G Single submitter
- c.110-636G>A Single submitter
- c.110-657T>C Single submitter
- c.*15C>T Single submitter
- c.*22G>A Single submitter
- p.Ala66Thr Single submitter ⚠
- p.Asn19Ser Single submitter ⚠
- p.Cys51= Single submitter
- p.His65Tyr Single submitter ⚠
- p.Lys62= Single submitter
- p.Pro45= Single submitter
- p.Val11Met Single submitter ⚠
- p.Val69Met Single submitter ⚠